Standard opieki okołooperacyjnej nad pacjentką leczoną z powodu nowotworu jajnika

Stworzenie aktualnych krajowych norm postępowania pielęgnacyjno-opiekuńczego w dziedzinie ginekologii onkologicznejjest koniecznością chwili. Coraz wyższa jakość opieki w medycynie, łącząca się w nierozerwalny sposób z podnoszeniemjakości opieki pielęgniarskiej, wymusza istnienie potrzeby systematyzowania, aktualizacji i określenia standardów w codziennejpraktyce położniczej. Celem pracy było przedstawienie projektu standardu opieki nad pacjentką leczoną z powodunowotworu jajnika opartego na przeglądzie piśmiennictwa i doświadczeniu praktycznym.W wyniku realizacji działań zgodnie z niniejszym standardem pacjentka chora na raka jajnika ma mieć zapewnioną profesjonalną,okołooperacyjną opiekę pielęgniarską. Proces pielęgnowania uwzględnia rzeczywiste, indywidualne problemy pielęgnacyjne.Położna zapewnia opiekę adekwatną do stanu fizycznego i psychicznego chorej. Zwiększa także motywację kobietydo przestrzegania zaleceń lekarskich związanych z koniecznością dalszego leczenia i wykonywania badań kontrolnych

Long-term results of treatment of advanced dermatofibrosarcoma protuberans (DFSP) with imatinib mesylate - The impact of fibrosarcomatous transformation

Dermatofibrosarcoma protuberans (DFSP) is rare, infiltrating dermal neoplasm, characterized by indolent growth and low probability of metastases. The first effective systemic therapy in DFSP introduced into clinical practice was imatinib, demonstrating high activity in advanced cases. The aim of the study was to perform an analysis of patients with advanced DFSP treated with imatinib, with or without surgery, in routine clinical practice with long-term follow-up.publisher: Elsevier articletitle: Long-term results of treatment of advanced dermatofibrosarcoma protuberans (DFSP) with imatinib mesylate – The impact of fibrosarcomatous transformation journaltitle: European Journal of Surgical Oncology (EJSO) articlelink: http://dx.doi.org/10.1016/j.ejso.2017.03.011 content_type: article copyright: © 2017 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.status: publishe

Effect of genotype, environment and their interaction on quality parameters of wheat breeding lines of diverse grain hardness

Understanding the contribution of genotype, environment and genotype-by-environment interaction to wheat grain quality facilitates the selection for quality in breeding programs. Stability of grain quality characteristics is an important requirement in the baking industry. We assessed 24 winter wheat genotypes with different grain hardness in multienvironment trials at four locations and two levels of fertilization in each location. Grain samples were analyzed for hardness, protein and starch content, and wet gluten content, Zeleny sedimentation value, alveograph parameter (W) and hectoliter weight. All parameters were evaluated on whole grains using the near infrared transmittance technique. Differences between hard and soft genotypes appeared to be significant, apart from grain hardness, for protein content, Zeleny test and alveograph parameter. Genotype was found to have a major influence only on grain hardness; for protein content, wet gluten and Zeleny sedimentation value environment prevailed the influence of genotype, and for starch content, alveograph W parameter and hectoliter weight both sources of variation had similar importance. Genotype-by-environment interaction was of smaller size relative to genotype and environment in terms of all the studied quality parameters. Stable genotypes predominate the breeding lines studied. Response of unstable genotypes to environmental conditions was nonlinear in most cases

Drug hypersensitivity reactions and allergy in patients with mastocytosis

Mastocytosis is a rare myeloproliferative disease caused by excessive proliferation and accumulation of mast cells in the skin and internal organs. The most common variant of mastocytosis in children is cutaneous mastocytosis. Systemic mastocytosis dominates in adults. Both CM and SM patients suffer from mast cell mediator-related symptoms such as itching, flushing, hypotension, abdominal pain, diarrhea, headache and anaphylaxis. The prevalence of anaphylaxis in patients with mastocytosis has been estimated to be about 50% in adults and about 9% in children. Anaphylaxis may be caused by many triggers including hymenoptera sting, drugs, physical factors, exercise, infections, alcohol, some food types and allergens. Drugs which may provoke anaphylaxis include nonsteroidal anti-inflammatory drugs, antibiotics, opioids, contrast media and muscle relaxants. Appropriate preparation of a patient for medical procedures and long-term prophylaxis allow one to reduce the risk of anaphylaxis in patients with mastocytosis

Non-neuronopathic Gaucher disease due to saposin C deficiency

Gaucher disease is generally caused by a deficiency of the lysosomal enzyme glucocerebrosidase. The degradation of glycosphingolipids requires also the participation of sphingolipid activator proteins. The prosaposin PSAP gene codes for a single protein which undergoes post-translational cleavage to yield four proteins named saposins A, B, C and D. Saposin (SAP-) C is required for glucosylceramide degradation, and its deficiency results in a variant form of Gaucher disease. In this report, we present clinical, biochemical, and molecular findings in a 36-year-old man and his 30-year-old sister with non-neuronopathic Gaucher disease due to SAP-C deficiency. Very high levels of chitotriosidase activity, chemokine CCL18, and increased concentration of glucosylceramide in plasma and normal beta-glucosidase activity in skin fibroblasts were observed in the patients. A molecular genetics study of the PSAP gene enabled the identification of one missense mutation, p.L349P, located in the SAP-C domain and another mutation, p.M1L, located in the initiation codon of the prosaposin precursor protein. The presented findings describe the first cases where the non-neuronopathic Gaucher disease has been definitely demonstrated to be a consequence of SAP-C deficiency. Three previously described cases in the literature displayed a Gaucher type 3 phenotyp