Multiple imaging by gravitational waves

Gravitational waves act like lenses for the light propagating through them. This phenomenon is described using the vector formalism employed for ordinary gravitational lenses, which was proved to be applicable also to a non-stationary spacetime, with the appropriate modifications. In order to have multiple imaging, an approximate condition analogous to that for ordinary gravitational lenses must be satisfied. Certain astrophysical sources of gravitational waves satisfy this condition, while the gravitational wave background, on average, does not. Multiple imaging by gravitational waves is, in principle, possible, but the probability of observing such a phenomenon is extremely low.Comment: 23 pages, LaTeX, no figures, to appear in Int. J. Mod. Phys.

Winterberg's conjectured breaking of the superluminal quantum correlations over large distances

We elaborate further on a hypothesis by Winterberg that turbulent fluctuations of the zero point field may lead to a breakdown of the superluminal quantum correlations over very large distances. A phenomenological model that was proposed by Winterberg to estimate the transition scale of the conjectured breakdown, does not lead to a distance that is large enough to be agreeable with recent experiments. We consider, but rule out, the possibility of a steeper slope in the energy spectrum of the turbulent fluctuations, due to compressibility, as a possible mechanism that may lead to an increased lower-bound for the transition scale. Instead, we argue that Winterberg overestimated the intensity of the ZPF turbulent fluctuations. We calculate a very generous corrected lower bound for the transition distance which is consistent with current experiments.Comment: 7 pages, submitted to Int. J. Theor. Phy

A Lorentz-Poincar\'e type interpretation of the Weak Equivalence Principle

The validity of the Weak Equivalence Principle relative to a local inertial frame is detailed in a scalar-vector gravitation model with Lorentz-Poincar\'e type interpretation. Given the previously established first Post-Newtonian concordance of dynamics with General Relativity, the principle is to this order compatible with GRT. The gravitationally modified Lorentz transformations, on which the observations in physical coordinates depend, are shown to provide a physical interpretation of \emph{parallel transport}. A development of ``geodesic'' deviation in terms of the present model is given as well.Comment: v1: 9 pages, 2 figures, v2: version to appear in International Journal of Theoretical Physic

Thermodynamic Gravity and the Schrodinger Equation

We adopt a 'thermodynamical' formulation of Mach's principle that the rest mass of a particle in the Universe is a measure of its long-range collective interactions with all other particles inside the horizon. We consider all particles in the Universe as a 'gravitationally entangled' statistical ensemble and apply the approach of classical statistical mechanics to it. It is shown that both the Schrodinger equation and the Planck constant can be derived within this Machian model of the universe. The appearance of probabilities, complex wave functions, and quantization conditions is related to the discreetness and finiteness of the Machian ensemble.Comment: Minor corrections, the version accepted by Int. J. Theor. Phy

A Census of the Chamaeleon I Star-Forming Region

Optical spectroscopy has been obtained for 179 objects that have been previously identified as possible members of the cluster, that lack either accurate spectral types or clear evidence of membership, and that are optically visible (I<18). I have used these spectroscopic data and all other available constraints to evaluate the spectral classifications and membership status of a total sample of 288 candidate members of Chamaeleon I that have appeared in published studies of the cluster. The latest census of Chamaeleon I now contains 158 members, 8 of which are later than M6 and thus are likely to be brown dwarfs. I find that many of the objects identified as members of Chamaeleon I in recent surveys are actually field stars. Meanwhile, 7 of 9 candidates discovered by Carpenter and coworkers are confirmed as members, one of which is the coolest known member of Chamaeleon I at a spectral type of M8 (~0.03 M_sun). I have estimated extinctions, luminosities, and effective temperatures for the members and used these data to construct an H-R diagram for the cluster. Chamaeleon I has a median age of ~2 Myr according to evolutionary models, and hence is similar in age to IC 348 and is slightly older than Taurus (~1 Myr). The measurement of an IMF for Chamaeleon I from this census is not possible because of the disparate methods with which the known members were originally selected, and must await an unbiased, magnitude-limited survey of the cluster.Comment: 59 pages, 22 figure

On Slow Light as a Black Hole Analogue

Although slow light (electromagnetically induced transparency) would seem an ideal medium in which to institute a ``dumb hole'' (black hole analog), it suffers from a number of problems. We show that the high phase velocity in the slow light regime ensures that the system cannot be used as an analog displaying Hawking radiation. Even though an appropriately designed slow-light set-up may simulate classical features of black holes -- such as horizon, mode mixing, Bogoliubov coefficients, etc. -- it does not reproduce the related quantum effects. PACS: 04.70.Dy, 04.80.-y, 42.50.Gy, 04.60.-m.Comment: 14 pages RevTeX, 5 figure

Sequential open-label study of the safety, tolerability, and pharmacokinetic interactions between dihydroartemisinin-piperaquine and mefloquine in healthy Thai adults

Artemisinin-based combination therapies (ACTs) have contributed substantially to the global decline in Plasmodium falciparum morbidity and mortality, but resistance to artemisinins and their partner drugs is increasing in Southeast Asia, threatening malaria control. New antimalarial compounds will not be generally available soon. Combining three existing antimalarials in the form of triple ACTs, including dihydroartemisinin (DHA)-piperaquine mefloquine, is a potential treatment option for multidrug-resistant Plasmodium falciparum malaria. In a sequential openlabel study, healthy Thai volunteers were treated with DHA-piperaquine (120 to 960 mg), mefloquine (500 mg), and DHA-piperaquine mefloquine (120 to 960 mg 500 mg), and serial symptom questionnaires, biochemistry, full blood counts, pharmacokinetic profiles, and electrocardiographic measurements were performed. Fifteen healthy subjects were enrolled. There was no difference in the incidence or severity of adverse events between the three treatment arms. The slight prolongation in QTc (QT interval corrected for heart rate) associated with DHA-piperaquine administration did not increase after administration of DHA-piperaquine mefloquine. The addition of mefloquine had no significant effect on the pharmacokinetic properties of piperaquine. However, coadministration of mefloquine significantly reduced the exposures to dihydroartemisinin for area under the concentration-time curve (22.6%; 90% confidence interval [CI], 33.1, 10.4; P = 0.0039) and maximum concentration of drug in serum (29.0%; 90% CI, 40.6, 15.1; P = 0.0079). Mefloquine can be added safely to dihydroartemisinin-piperaquine in malaria treatment. (This study has been registered at ClinicalTrials.gov under identifier NCT02324738.

Safety, pharmacokinetics, and mosquito‐lethal effects of ivermectin in combination with dihydroartemisinin‐piperaquine and primaquine in healthy adult Thai subjects

Mass administration of antimalarial drugs and ivermectin are being considered as potential accelerators of malaria elimination. The safety, tolerability, pharmacokinetics and mosquito-lethal effects of combinations of ivermectin, dihydroartemisinin-piperaquine, and primaquine were evaluated. Co-administration of ivermectin and dihydroartemisinin-piperaquine, resulted in increased ivermectin concentrations with corresponding increases in mosquito-lethal effect across all subjects. Exposure to piperaquine was also increased when co-administered with ivermectin, but electrocardiograph QT-interval prolongation was not increased. One subject had transiently impaired liver function. Ivermectin mosquito-lethal effect was greater than predicted previously against the major Southeast Asian malaria vectors. Both Anopheles dirus and Anopheles minimus mosquito mortality was increased substantially (20-fold and 35-fold increase, respectively) when feeding on volunteer blood after ivermectin administration compared to in vitro ivermectin-spiked blood. This suggests the presence of ivermectin metabolites that impart mosquito-lethal effects. Further studies of this combined approach to accelerate malaria elimination are warranted