Mediated Class-ifications: Representations of Class and Culture in Contemporary British Television

This article takes, as its point of departure, recent debates about the representation of working-class life, especially the lives of the 'feckless poor', on reality television in the UK. These issues are contextualized by reference to a set of wider-ranging historical debates about: a) the category of class as a mode of social determination (and as an explanatory model); b) the relations of language, class and culture in educational sociology and in community publishing; and, c) in relation to classical Marxism's theorization of both the 'respectable' working class and the lumpen proletariat. The article concludes with a consideration of debates about the representation of the working class in the contemporary British TV drama series Shameless

CXC receptor-4 mRNA silencing abrogates CXCL12-induced migration of colorectal cancer cells

<p>Abstract</p> <p>Background</p> <p>Interactions between CXCR4 and its ligand CXCL12 have been shown to be involved in cancer progression in colorectal cancer (CRC). We performed a comparative CXCL12/CXCR4 expression analysis and assessed the effect of external CXCL12 stimulation on migration of CRC cells without and with CXCR4 inhibition.</p> <p>Methods</p> <p>Expression of CXCL12/CXCR4 was assessed by quantitative real-time PCR, ELISA and immunohistochemistry in resection specimens of 50 CRC patients as well as in the corresponding normal tissues and in three human CRC cell lines with different metastatic potential (Caco-2, SW480 and HT-29). Migration assays were performed after stimulation with CXCL12 and CXCR4 was inhibited by siRNA and neutralizing antibodies.</p> <p>Results</p> <p>In CRC tissues CXCL12 was significantly down-regulated and CXCR4 was significantly up-regulated compared to the corresponding normal tissues. In cell lines CXCR4 was predominantly expressed in SW480 and less pronounced in HT-29 cells. CXCL12 was only detectable in Caco-2 cells. CXCL12 stimulation had no impact on Caco-2 cells but significantly increased migration of CXCR4 bearing SW480 and HT-29 cells. This effect was significantly abrogated by neutralizing anti-CXCR4 antibody as well as by CXCR4 siRNAs (P < 0.05).</p> <p>Conclusions</p> <p>CXCR4 expression was up-regulated in CRC and CXCL12 stimulation increased migration in CXCR4 bearing cell lines. Migration was inhibited by both neutralizing CXCR4 antibodies and CXCR4 siRNAs. Thus, the expression and functionality of CXCR4 might be associated with the metastatic potential of CRC cells and CXCL12/CXCR4 interactions might therefore constitute a promising target for specific treatment interventions.</p

A comparison of the gender-specificity of age of consent legislation in Europe and China: Towards a gender-neutral age of consent in China?

Age of consent—the age at which young people are considered legally competent to consent to sexual activities—is an important weapon invented by law makers to protect young children from being sexually abused and exploited by predatory adults. In this study, a comparison of the age of consent legislation in 2004 and 2016 in Europe reveals that it is a trend for European law makers to adopt a gender-neutral approach in their age of consent legislation, i.e., the gender of the sexual participants does not affect the legal consequence of the sexual activity and both male and female children, either in heterosexual or homosexual relations, enjoy protection to the same extent. Then the age of consent legislation in China is deeply examined to see whether it is gender-neutral as most of the European jurisdictions. Based on the previous introduction and analysis of Europe and China, this paper concludes that the gender-neutral trend identified in Europe could be instructive for China’s future age of consent legislation

Fast Girls, Foreigners and GIs : An Exploration of the Discursive Strategies Through Which the Status of Pre-Marital (Hetero) sexual Ignorance and Restraint Was Upheld During the Second World War

This paper explores contradictions within qualitative data gathered among women and men whose young adulthood coincided with the Second World War. These data were generated as part of an ESRC-funded project which investigated the making of heterosexual relationships cross-generationally. They suggest the co-existence of both a prevalent taboo or stigma associated with sexual knowledge and practice before and outside marriage, and personal experiences of precisely these engagements with embodied sexuality. Drawing on Charles Tilly's work, the paper argues that, when interrogated, these contradictions can reveal the strategies through which a creaky heterosexual consensus was shored up during a period of military upheaval that profoundly destabilised existing beliefs and practices. Tilly differentiated between academic historians who sought to reconcile 'very large structural changes' and 'the changing experiences of ordinary people' through either collectivist or individualist approaches to 'history from below'. Neither of these methods could yield an adequate account, in his view. However, the 'lay historians' who participated in our study combined collectivist and individualist perspectives, thereby providing a unique insight into an era when collective values and individual practices were often in tension with one another. As our participants spoke about their young adulthood, their data revealed the potency of local gossip which mobilised wider discourses of alterity or 'othering', so shoring up a consensual view of sexual mores, despite the prevalence of attitudes and practices that contravened it. What we argue, therefore, is that rather than a half-remembered, contradictory account of heterosexuality during the 1920s and 1930s, the data we gathered in the early 21st century exemplifies precisely the discursive strategies of that period. In other words, these data shed light on the ways in which not only heterosexual norms, but also an entire, endangered system of distinctions based on class, gender and national identity was upheld.Peer reviewe