APOPTOTIC INDUCTION POTENTIALS OF BACOPA MONERI AGAINST ORAL CANCER CELL LINE

Aim: To assess the apoptotic induction potentials of Bacopa monnieri against oral cancer cell.Objective: This research is done to find the apoptotic induction potentials of B. monnieri against oral cancer cell line.Background: The apoptosis is a process of programed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cellchanges and death. The initiation of apoptosis is tightly regulated by activation mechanisms, because once apoptosis has begun, it inevitably leadsto the death of the cell. The two best-understood activation mechanisms are the intrinsic pathway (also called the mitochondrial pathway) and theextrinsic pathway.Methods: The apoptotic induction potential of B. monnieri was studied on KB cell line by investigating the activation of caspase 3 and caspase 9.Reason: Oral cancer is a growing concern due to the changes in lifestyle. The treatment for this disease has been degraded the patient's health bycausing various side effects. An effective treatment for the long run is necessary. Usable of herbal plants can serve to be a possible and very effective remedy.Results: Apoptotic induction potentials of B. monnieri against oral cancer cell line were studied.Conclusion: Caspase 3 and caspase 9 was activated thus proving the apoptotic potential of B. monnieri.Keywords: Bacopa monnieri, oral cancer, apoptotic induction

Machine Learning Algorithm to Identify Hesitancy Towards Covid-19 Vaccination Among the Rural Citizens Under E-Governance Initiatives

The Indian Government has taken massive initiatives to control the pandemic virus of COVID-19. Recently, the Government has decided to begin the process of a large-scale vaccination programme to create an end to the crisis due to COVID-19. However, vaccination is found to be the major solution as suggested by various health care experts to stop the widespread of this deadly virus, hesitancy towards getting vaccinated is found to be more in the rural villages of India. The process of getting vaccinated was not made compulsory by the government, but still there exists skepticism in minds of rural citizens towards COVID-19 vaccination. Text Analytics has been implemented to identify the exact emotions among rural citizens towards COVID Vaccinations. Hence the present research study has identified the major reasons for hesitancy towards getting vaccinated for COVID-19 using machine learning techniques. The researchers of the current study have also measured the emotions and signs of sentiments of the rural citizens on COVID-19 vaccination

Hydrolysis of proteinaceous tannery solid waste for the production of extracellular acidic protease by Selenomonas ruminantium

The objective of this study was to produce protease from Selenomonas ruminantium using animal fleshing (ANFL), an untanned tannery solid waste as the sole protein source. Optimization of the minimal medium composition for the production of protease was carried out by a statistical approach using response surface methodology (RSM) which includes the variables such as NH4Cl, K2HPO4, KH2PO4 and NaCl. The isolate was found to produce maximum protease at pH 6 and at a temperature of about 40°C. Protease was purified 56 fold with a total yield of 28.14%. The enzyme was found to be monomeric having a molecular weight around 53 kDa. The purified enzyme was stable at a pH of about 4 revealing its acid protease nature and was also found to be stable up to 40°C. The enzyme was activated by divalent cations like Ca2+ and Mg2+ and inhibited by dithiothreitol (DTT), where the latter suggested its cysteine protease nature. The enzyme had good stability in the presence of non-ionic surfactants like tween 20, tween 40, tween 80 and triton X100 and also in the presence of solvents like methanol, ethanol and isopropanol. These characteristics reveal the potential of the enzyme for different industrial applications.Keywords: Acid protease, animal fleshing, optimization, response surface methodology (RSM), Selenomonas ruminantiu

Jamming Attack Detection and Evaluating Using Wireless Application

When data is transferred from one host to another host,attacker may try to attack the packet or data which is in transit.Inorder to avoid such kind of attack in time critical wireless application and delivery message securely in wireless application. In this paper, we aim at modeling and detecting jamming attacks against time-critical wireless networks.To measure network performance ,packet loss and throughput metrics are used . To quantify the performance of time-critical applications,message invalidation ratio metric are used. This approach is inspired by the similarity between the behavior of a jammer who attempts to disrupt the delivery of a message and the behavior of a gambler who intends to win a gambling game. By gambling-based modeling and real-time modules, we can successful delivery time-critical message under a variety of jamming attacks. DOI: 10.17762/ijritcc2321-8169.15038

Design and Analysis of a Sustainable LV Residential Microgrid

AbstractIn the present scenario, power cuts are daily occurrences in many parts of the world. People all over the world would like to avoid these unscheduled power cuts and have a reliable, secure and clean electricity. For an affordable energy usage, sustainable power generation with renewable resources are highly recommended for environment friendly generation of energy with lower carbon footprints. They are isolated from the utility grid in case of any power outage or power blackouts. The key objective of this work is to model a self-sustained microgrid from the existing Indian distribution feeder, which means a small scale interconnected, centralized single controllable system where the particular arena is supplied with distributed energy resources like solar and wind instead of the main grid. The existing system of a particular region supplied with 42 bus system layout connected with 100 KVA transformer. Wind and the solar sources are designed individually and this hybrid energy is interconnected with the layout model to make up a small, modern self-sustained grid called the microgrid. The results are obtained in PSCAD software package with several case studies

Art and craft of episiotomy

Background: Episiotomy is the most common obstetric surgical procedure performed in labor room. Mediolateral and Midline episiotomies are the most common types. Post-delivery suture angle is the most important determinant factor which predicts the risk of anal sphincter injuries. Mediolateral episiotomy has a significantly lower risk of OASIS rate when compared to midline episiotomies. Aim of the study was to know whether mediolateral episiotomies are actually mediolateral and does the angle of episiotomy influences the risk of anal sphincter injuries, maternal/fetal complications in the perinatal period.Methods: An observational study was conducted on 250 postpartum patients admitted to our hospital. Details of episiotomy in relation to incision angle, length, depth and post suturing angle were noted within two days of delivery.Results: Among the subjects included there were 40.8 % incisions were RMLE, average length was 3.32cms, average suture angle is 28.69 degree. OASIS was seen in 19.5% cases more so with midline episiotomies.Conclusions: Episiotomy is an essential, must to know skill. Compulsory ssupervised clinical teaching and use of skill lab training can prevent potential detrimental consequences

Hematological and Inflammatory Biomarkers among Stable COPD and Acute Exacerbations of COPD Patients

Objectives: Chronic Obstructive Pulmonary Disease (COPD) is heterogeneous in nature. Acute exacerbation of COPD (AECOPD) is diagnosed clinically which is subjective and clinical judgment may vary from clinician to clinician. Since chronic inflammation underlies the pathogenesis of COPD, markers of inflammation have generated lot of interest for their potential to be used as biomarkers of COPD. This study aimed to assess the variation in levels of neutrophil lymphocyte ratio (NLR) and platelet indices in patients with stable COPD and acute exacerbation of COPD patients and its association with GOLD stages. Methods: This prospective analytical study was carried out in our tertiary care hospital from December 2018 to July 2020. About 64 subjects (32- stable COPD, 32- AECOPD) who satisfied study criteria were included. Blood sample was taken from stable and AECOPD patients and were compared. Results: It was observed that Neutrophil Lymphocyte Ratio, Platelet Distribution Width, Erythrocyte Sedimentation Rate and C-Reactive Protein were increased in AECOPD patients when compared with stable COPD patients which was statistically significant with p value of <0.001. A positive correlation was observed between Neutrophil Lymphocyte Ratio, Platelet Distribution Width and Erythrocyte Sedimentation Rate, C-Reactive Protein which was statistically significant with p value of <0.001. Conclusion: We found that neutrophil lymphocyte ratio and platelet distribution width values increased significantly in AECOPD patients when compared to stable COPD patients. Keywords: AECOPD; COPD; Neutrophil Lymphocyte Ratio; Platelet Distribution Width

Fitted mesh method for singularly perturbed fourth order differential equation of convection diffusion type with integral boundary condition

This article focuses on a class of fourth-order singularly perturbed convection diffusion equations (SPCDE) with integral boundary conditions (IBC). A numerical method based on a finite difference scheme using Shishkin mesh is presented. The proposed method is close to the first-order convergent. The discrete norm yields an error estimate and theoretical estimations are tested by numerical experiments