A Systematic Analysis of Fe II Emission in Quasars: Evidence for Inflow to the Central Black Hole

Broad Fe II emission is a prominent feature of the optical and ultraviolet spectra of quasars. We report on a systematical investigation of optical Fe II emission in a large sample of 4037 z < 0.8 quasars selected from the Sloan Digital Sky Survey. We have developed and tested a detailed line-fitting technique, taking into account the complex continuum and narrow and broad emission-line spectrum. Our primary goal is to quantify the velocity broadening and velocity shift of the Fe II spectrum in order to constrain the location of the Fe II-emitting region and its relation to the broad-line region. We find that the majority of quasars show Fe II emission that is redshifted, typically by ~ 400 km/s but up to 2000 km/s, with respect to the systemic velocity of the narrow-line region or of the conventional broad-line region as traced by the Hbeta line. Moreover, the line width of Fe II is significantly narrower than that of the broad component of Hbeta. We show that the magnitude of the Fe II redshift correlates inversely with the Eddington ratio, and that there is a tendency for sources with redshifted Fe II emission to show red asymmetry in the Hbeta line. These characteristics strongly suggest that Fe II originates from a location different from, and most likely exterior to, the region that produces most of Hbeta. The Fe II-emitting zone traces a portion of the broad-line region of intermediate velocities whose dynamics may be dominated by infall.Comment: 20 pages, 14 figures, accepted for publication in Ap

Parsimonious continuous time random walk models and kurtosis for diffusion in magnetic resonance of biological tissue

In this paper, we provide a context for the modeling approaches that have been developed to describe non-Gaussian diffusion behavior, which is ubiquitous in diffusion weighted magnetic resonance imaging of water in biological tissue. Subsequently, we focus on the formalism of the continuous time random walk theory to extract properties of subdiffusion and superdiffusionthrough novel simplifications of the Mittag-Leffler function. For the case of time-fractional subdiffusion, we compute the kurtosis for the Mittag-Leffler function, which provides both a connection and physical context to the much-used approach of diffusional kurtosis imaging. We provide Monte Carlo simulations to illustrate the concepts of anomalous diffusion as stochastic processes of the random walk. Finally, we demonstrate the clinical utility of the Mittag-Leffler function as a model to describe tissue microstructure through estimations of subdiffusion and kurtosis with diffusion MRI measurements in the brain of a chronic ischemic stroke patient

Nuclear receptors in vascular biology

Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics. In response to these diverse but critically important mediators, nuclear receptors regulate the homeostatic control of lipids, carbohydrate, cholesterol, and xenobiotic drug metabolism, inflammation, cell differentiation and development, including vascular development. The nuclear receptor family is one of the most important groups of signaling molecules in the body and as such represent some of the most important established and emerging clinical and therapeutic targets. This review will highlight some of the recent trends in nuclear receptor biology related to vascular biology

Chandra Observation of the Cluster of Galaxies MS 0839.9+2938 at z=0.194: the Central Excess Iron and SN Ia Enrichment

We present the Chandra study of the intermediately distant cluster of galaxies MS 0839.9+2938. By performing both the projected and deprojected spectral analyses, we find that the gas temperature is approximately constant at about 4 keV in 130-444h_70^-1 kpc. In the inner regions, the gas temperature descends towards the center, reaching <~ 3 keV in the central 37h_70^-1 kpc. This infers that the lower and upper limits of the mass deposit rate are 9-34 M_sun yr^-1 and 96-126 M_sun yr^-1, respectively within 74h_70^-1 kpc where the gas is significantly colder. Along with the temperature drop, we detect a significant inward iron abundance increase from about 0.4 solar in the outer regions to about 1 solar within the central 37h_70^-1 kpc. Thus MS 0839.9+2938 is the cluster showing the most significant central iron excess at z>~ 0.2. We argue that most of the excess iron should have been contributed by SNe Ia. By utilizing the observed SN Ia rate and stellar mass loss rate, we estimate that the time needed to enrich the central region with excess iron is 6.4-7.9 Gyr, which is similar to those found for the nearby clusters. Coinciding with the optical extension of the cD galaxy (up to about 30h_70^-1 kpc), the observed X-ray surface brightness profile exhibits an excess beyond the distribution expected by either the beta model or the NFW model, and can be well fitted with an empirical two-beta model that leads to a relatively flatter mass profile in the innermost region.Comment: Accepted for publication in Ap

Wide-Scale Analysis of Human Functional Transcription Factor Binding Reveals a Strong Bias towards the Transcription Start Site

We introduce a novel method to screen the promoters of a set of genes with shared biological function, against a precompiled library of motifs, and find those motifs which are statistically over-represented in the gene set. The gene sets were obtained from the functional Gene Ontology (GO) classification; for each set and motif we optimized the sequence similarity score threshold, independently for every location window (measured with respect to the TSS), taking into account the location dependent nucleotide heterogeneity along the promoters of the target genes. We performed a high throughput analysis, searching the promoters (from 200bp downstream to 1000bp upstream the TSS), of more than 8000 human and 23,000 mouse genes, for 134 functional Gene Ontology classes and for 412 known DNA motifs. When combined with binding site and location conservation between human and mouse, the method identifies with high probability functional binding sites that regulate groups of biologically related genes. We found many location-sensitive functional binding events and showed that they clustered close to the TSS. Our method and findings were put to several experimental tests. By allowing a "flexible" threshold and combining our functional class and location specific search method with conservation between human and mouse, we are able to identify reliably functional TF binding sites. This is an essential step towards constructing regulatory networks and elucidating the design principles that govern transcriptional regulation of expression. The promoter region proximal to the TSS appears to be of central importance for regulation of transcription in human and mouse, just as it is in bacteria and yeast.Comment: 31 pages, including Supplementary Information and figure

Domain wall fermion zero modes on classical topological backgrounds

The domain wall approach to lattice fermions employs an additional dimension, in which gauge fields are merely replicated, to separate the chiral components of a Dirac fermion. It is known that in the limit of infinite separation in this new dimension, domain wall fermions have exact zero modes, even for gauge fields which are not smooth. We explore the effects of finite extent in the fifth dimension on the zero modes for both smooth and non-smooth topological configurations and find that a fifth dimension of around ten sites is sufficient to clearly show zero mode effects. This small value for the extent of the fifth dimension indicates the practical utility of this technique for numerical simulations of QCD.Comment: Updated fig. 3-7, small changes in sect. 3, added fig. 8, added more reference

Large tunable valley splitting in edge-free graphene quantum dots on boron nitride

Coherent manipulation of binary degrees of freedom is at the heart of modern quantum technologies. Graphene offers two binary degrees: the electron spin and the valley. Efficient spin control has been demonstrated in many solid state systems, while exploitation of the valley has only recently been started, yet without control on the single electron level. Here, we show that van-der Waals stacking of graphene onto hexagonal boron nitride offers a natural platform for valley control. We use a graphene quantum dot induced by the tip of a scanning tunneling microscope and demonstrate valley splitting that is tunable from -5 to +10 meV (including valley inversion) by sub-10-nm displacements of the quantum dot position. This boosts the range of controlled valley splitting by about one order of magnitude. The tunable inversion of spin and valley states should enable coherent superposition of these degrees of freedom as a first step towards graphene-based qubits

Towards a Proof Theory of G\"odel Modal Logics

Analytic proof calculi are introduced for box and diamond fragments of basic modal fuzzy logics that combine the Kripke semantics of modal logic K with the many-valued semantics of G\"odel logic. The calculi are used to establish completeness and complexity results for these fragments

Encapsulation of graphene transistors and vertical device integration by interface engineering with atomic layer deposited oxide

We demonstrate a simple, scalable approach to achieve encapsulated graphene transistors with negligible gate hysteresis, low doping levels and enhanced mobility compared to as-fabricated devices. We engineer the interface between graphene and atomic layer deposited (ALD) Al$_{2}$O$_{3}$ by tailoring the growth parameters to achieve effective device encapsulation whilst enabling the passivation of charge traps in the underlying gate dielectric. We relate the passivation of charge trap states in the vicinity of the graphene to conformal growth of ALD oxide governed by $\textit{in situ}$ gaseous H$_{2}$O pretreatments. We demonstrate the long term stability of such encapsulation techniques and the resulting insensitivity towards additional lithography steps to enable vertical device integration of graphene for multi-stacked electronics fabrication.This work was supported by the EPSRC (Grant Nos. EP/K016636/1, GRAPHTED and EP/L020963/1) and the ERC (Grant No. 279342, InsituNANO). JAA-W acknowledges a Research Fellowship from Churchill College, Cambridge. JS acknowledges support from NUDT. ZAVV acknowledges funding from ESPRC grant EP/L016087/1. ACV acknowledges the Conacyt Cambridge Scholarship and the Roberto Rocca Fellowship. RW acknowledges EPSRC Doctoral Training Award (EP/M506485/1)