How does a protein search for the specific site on DNA: the role of disorder

Proteins can locate their specific targets on DNA up to two orders of magnitude faster than the Smoluchowski three-dimensional diffusion rate. This happens due to non-specific adsorption of proteins to DNA and subsequent one-dimensional sliding along DNA. We call such one-dimensional route towards the target "antenna". We studied the role of the dispersion of nonspecific binding energies within the antenna due to quasi random sequence of natural DNA. Random energy profile for sliding proteins slows the searching rate for the target. We show that this slowdown is different for the macroscopic and mesoscopic antennas.Comment: 4 pages, 4 figure

Estimates for practical quantum cryptography

In this article I present a protocol for quantum cryptography which is secure against attacks on individual signals. It is based on the Bennett-Brassard protocol of 1984 (BB84). The security proof is complete as far as the use of single photons as signal states is concerned. Emphasis is given to the practicability of the resulting protocol. For each run of the quantum key distribution the security statement gives the probability of a successful key generation and the probability for an eavesdropper's knowledge, measured as change in Shannon entropy, to be below a specified maximal value.Comment: Authentication scheme corrected. Other improvements of presentatio

Search for Majorana neutrinos with the first two years of EXO-200 data

Many extensions of the standard model of particle physics suggest that neutrinos should be Majorana-type fermions—that is, that neutrinos are their own anti-particles—but this assumption is difficult to confirm. Observation of neutrinoless double-β decay (0νββ), a spontaneous transition that may occur in several candidate nuclei, would verify the Majorana nature of the neutrino and constrain the absolute scale of the neutrino mass spectrum. Recent searches carried out with ^(76)Ge (the GERDA experiment) and ^(136)Xe (the KamLAND-Zen and EXO (Enriched Xenon Observatory)-200 experiments) have established the lifetime of this decay to be longer than 10^(25) years, corresponding to a limit on the neutrino mass of 0.2–0.4 electronvolts. Here we report new results from EXO-200 based on a large ^(136)Xe exposure that represents an almost fourfold increase from our earlier published data sets. We have improved the detector resolution and revised the data analysis. The half-life sensitivity we obtain is 1.9 × 10^(25) years, an improvement by a factor of 2.7 on previous EXO-200 results. We find no statistically significant evidence for 0νββ decay and set a half-life limit of 1.1 × 10^(25)  years at the 90 per cent confidence level. The high sensitivity holds promise for further running of the EXO-200 detector and future 0νββ decay searches with an improved Xe-based experiment, nEXO

A prototype vector magnetic field monitoring system for a neutron electric dipole moment experiment

We present results from a first demonstration of a magnetic field monitoring system for a neutron electric dipole moment experiment. The system is designed to reconstruct the vector components of the magnetic field in the interior measurement region solely from exterior measurements

Interplay between geometry and flow distribution in an airway tree

Uniform fluid flow distribution in a symmetric volume can be realized through a symmetric branched tree. It is shown here, however, that the flow partitioning can be highly sensitive to deviations from exact symmetry if inertial effects are present. This is found by direct numerical simulation of the Navier-Stokes equations in a 3D tree geometry. The flow asymmetry is quantified and found to depend on the Reynolds number. Moreover, for a given Reynolds number, we show that the flow distribution depends on the aspect ratio of the branching elements as well as their angular arrangement. Our results indicate that physiological variability should be severely restricted in order to ensure uniform fluid distribution in a tree. This study suggests that any non-uniformity in the air flow distribution in human lungs should be influenced by the respiratory conditions, rest or hard exercise

Security of quantum cryptography using balanced homodyne detection

In this paper we investigate the security of a quantum cryptographic scheme which utilizes balanced homodyne detection and weak coherent pulse (WCP). The performance of the system is mainly characterized by the intensity of the WCP and postselected threshold. Two of the simplest intercept/resend eavesdropping attacks are analyzed. The secure key gain for a given loss is also discussed in terms of the pulse intensity and threshold.Comment: RevTeX4, 8pages, 7 figure

Complete physical simulation of the entangling-probe attack on the BB84 protocol

We have used deterministic single-photon two qubit (SPTQ) quantum logic to implement the most powerful individual-photon attack against the Bennett-Brassard 1984 (BB84) quantum key distribution protocol. Our measurement results, including physical source and gate errors, are in good agreement with theoretical predictions for the Renyi information obtained by Eve as a function of the errors she imparts to Alice and Bob's sifted key bits. The current experiment is a physical simulation of a true attack, because Eve has access to Bob's physical receiver module. This experiment illustrates the utility of an efficient deterministic quantum logic for performing realistic physical simulations of quantum information processing functions.Comment: 4 pages, 5 figure

Security against individual attacks for realistic quantum key distribution

I prove the security of quantum key distribution against individual attacks for realistic signals sources, including weak coherent pulses and downconversion sources. The proof applies to the BB84 protocol with the standard detection scheme (no strong reference pulse). I obtain a formula for the secure bit rate per time slot of an experimental setup which can be used to optimize the performance of existing schemes for the considered scenario.Comment: 10 pages, 4 figure

Enhanced reaction kinetics in biological cells

The cell cytoskeleton is a striking example of "active" medium driven out-of-equilibrium by ATP hydrolysis. Such activity has been shown recently to have a spectacular impact on the mechanical and rheological properties of the cellular medium, as well as on its transport properties : a generic tracer particle freely diffuses as in a standard equilibrium medium, but also intermittently binds with random interaction times to motor proteins, which perform active ballistic excursions along cytoskeletal filaments. Here, we propose for the first time an analytical model of transport limited reactions in active media, and show quantitatively how active transport can enhance reactivity for large enough tracers like vesicles. We derive analytically the average interaction time with motor proteins which optimizes the reaction rate, and reveal remarkable universal features of the optimal configuration. We discuss why active transport may be beneficial in various biological examples: cell cytoskeleton, membranes and lamellipodia, and tubular structures like axons.Comment: 10 pages, 2 figure

GEO 600 and the GEO-HF upgrade program: successes and challenges

The German-British laser-interferometric gravitational wave detector GEO 600 is in its 14th year of operation since its first lock in 2001. After GEO 600 participated in science runs with other first-generation detectors, a program known as GEO-HF began in 2009. The goal was to improve the detector sensitivity at high frequencies, around 1 kHz and above, with technologically advanced yet minimally invasive upgrades. Simultaneously, the detector would record science quality data in between commissioning activities. As of early 2014, all of the planned upgrades have been carried out and sensitivity improvements of up to a factor of four at the high-frequency end of the observation band have been achieved. Besides science data collection, an experimental program is ongoing with the goal to further improve the sensitivity and evaluate future detector technologies. We summarize the results of the GEO-HF program to date and discuss its successes and challenges