41 research outputs found
Changes in permeability of the Nojima fault damage zone inferred from repeated water injection experiments
Hydraulic diffusivity of fault gouge zones and implications for thermal pressurization during seismic slip
Adaptive Pulse Width Control for Precise Positioning Under the Influence of Stiction and Coulomb Friction
For the robustness experiment, the friction is increased by increasing the sealing pressure. The PID control exhibits a large overshoot during the transient state, while the other controllers exhibit no overshoot, as shown in Figs. 4 and 5. In the SMC, errors are reduced very slowly and the steady-state error is relatively large as shown in Fig. 5. Settling times of the PID control, the TDC, and the TDSMC are 3.32 s, 2.96 s, and 1.94 s, respectively, as shown in Figs. 4{b) and 5(^). The PID control and the TDC perform very poorly and their settling times are increased by 90.8 and 105.6 percent, respectively, from their nominal values. On the other hand, the TDSMC performs very well and its settling time is increased only by 9 percent from the nominal value. Therefore, the TDSMC has the best performance robustness. Conclusions The TDSMC which is a combination of the TDC and the SMC is proposed for the system with unknown dynamics and disturbances. This method uses the idea of switching of the sliding mode control while reducing the chattering associated with it. Experiments on the position control of a DC motor system with stick-slip friction, were conducted to evaluate performances of the control algorithms. Experiments show that the TDSMC exhibits the best performance robustness and that the TDC and the TDSMC perform better than the PID control with an anti-windup filter and the integral sliding mode control. 227. Youcef-Touini, K., and Bobbet, J., 1991, "Stability of Uncertain Linear Systems With Time Delay," ASME JOURNAL OF DYNAMIC SYSTEMS, MEASUREMENT, AND CONTROL, Vol. 113, pp. 558-567. Youcef-Toumi, K., and Ito, O., 1990, "A Time Delay Controller for Systems With Unknown Dynamics," ASME JOURNAL OF DYNAMIC SYSTEMS, MEASURE- MENT, AND CONTROL, Vol. 112, Youcef-Toumi, K., and Reddy, S., 1992, "Analysis of Linear Time Invariant Systems With Time Delay," ASME JOURNAL OF DYNAMIC SYSTEMS, MEASURE- MENT, AND CONTROL, Vol. 114, Youcef-Toumi, K., and Wu, S.-T., 1992, "Input/Output Linearization Using Time Delay Control," ASME JOURNAL OF DYNAMIC SYSTEMS, MEASUREMENT, AND CONTROL, Vol. 114, pp. 10-19
Prospective phase II trial of everolimus in PIK3CA amplification/mutation and/or PTEN loss patients with advanced solid tumors refractory to standard therapy
Rapid and fatal acute heart failure induced by pazopanib
Tyrosine kinase inhibitors, represented by sunitinib, sorafenib, axitinib and pazopanib, are emerging molecules harbouring antitumoural efficacy in multiple neoplasia. We report the case of a 51-year-old woman with right thoracic sarcoma who developed fatal heart failure on pazopanib. The patient had no cardiovascular risk factor, except previous exposure to anthracycline, and her cardiac function was normally controlled before initiating the pazopanib. Despite a rapid tumour response, fatigue rapidly appeared, requiring treatment interruption 2 weeks after pazopanib introduction. After clinical improvement, the pazopanib was reintroduced at reduced dose; however, a few days later, our patient was admitted for worsening dyspnoea and fatigue. Pulmonary embolism was excluded as was pleuropericardial effusion. Brain natriuretic peptide was the only laboratory abnormality, and echocardiography revealed acute and severe heart failure. The patient died despite pazopanib arrest and inotropic support. Copyright 2015 BMJ Publishing Group. All rights reserved
Retrospective analysis of definitive chemoradiotherapy with either high-dose or weekly cisplatin in patients with locally advanced squamous cell head and neck cancer: 2-year outcome
2858 Definitive chemoradiotherapy with either high-dose or weekly cisplatin in patients with locally advanced squamous cell head and neck cancer: A retrospective analysis
Update on the management of renal cell carcinoma: The BSMO expert panel recommendations
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