Coherent Flow Structures over Scour Marks Generated by Obstacles of Different Shapes

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

Isospin mode splitting and mixing in asymmetric nuclear matter

We estimate exclusive density and asymmetry parameter dependent dispersion relations of various charged states of pions in asymmetric nuclear matter. The possibility of matter induced mixing of $\pi^0$ with $\eta$ is clearly exposed with the further mass modification of $\pi^0$ meson due to mixing. Asymmetry driven mass splitting and mixing amplitude are of the same order as the corresponding values in vacuum. Closed form analytic results for the mass shifts and dispersion relations with and without mixing are presented. Furthermore, we discuss the sensitivity of our results on the scalar mean field within the framework of Quantum Hadrodynamics.Comment: 8 pages, 4 Figure

Formulation and evaluation of matrix microspheres for simultaneous delivery of salbutamol sulphate and theophylline

Purpose: The objective of this study was to formulate and evaluate a matrix microsphere system for simultaneous delivery of two anti-asthmatic drugs Salbutamol sulphate and Theophylline which are often indicated for the management of asthma, their frequent dosing may reduce compliance, thus making a prolonged release formulation necessary. Ethylcellulose was used as a retardant polymer and its compatibility with the drugs and the drug-drug compatibility were established through IR, XRD and DSC studies. Method: Microspheres were prepared by emulsion solvent evaporation using acetone/light liquid paraffin system. Tween 80 was used as the dispersing agent and cyclohexane was added to harden the microspheres. The prepared microspheres were characterized for their micromeritic properties and drug loading, as well as by infrared spectroscopy (IR), differential scanning calorimetry (DSC), x-ray powder diffractometry (XRD) and scanning electron microscopy (SEM). The in vitro release studies were performed in pH 7.4, phosphate buffer. Result: The prepared microspheres were white, free flowing and spherical in shape. The drug-loaded microspheres showed 67-91% of entrapment and release was extended upto 6 to 8 h. The infrared spectra, differential scanning calorimetry thermographs and XRD spectra all showed the stable character of both the drugs in the drug-loaded microspheres and revealed the absence of drug-polymer interactions. Scanning electron microscopy study revealed that the microspheres were spherical and porous in nature. Conclusion: The matrix microspheres have a potential for the prolongation and simultaneous delivery of the anti asthmatic drugs (salbutamol and theophylline). Keywords: Matrix microspheres, Salbutamol sulphate, Theophylline, Ethylcellulose, Emulsion solvent evaporation technique. Tropical Journal of Pharmaceutical Research Vol. 7 (2) 2008: pp. 995-100

Validity of the Generalized Second Law of Thermodynamics of the Universe Bounded by the Event Horizon in Brane Scenario

In this paper, we examine the validity of the generalized second law of thermodynamics (GSLT) of the universe bounded by the event horizon in brane-world gravity. Here we consider homogeneous and isotropic model of the universe filled with perfect fluid in one case and in another case holographic dark energy model of the universe has been considered. The conclusions are presented point wise.Comment: 8 pages, the paper has been accepted in EPJC for publication. Conclusion has been modified an some references have been adde

Scalar-Tensor Theory of Gravity and Generalized Second Law of Thermodynamics on the Event Horizon

In blackhole physics, the second law of thermodynamics is generally valid whether the blackhole is a static or a non-static one. Considering the universe as a thermodynamical system the second law of blackhole dynamics extends to the non-negativity of the sum of the entropy of the matter and the horizon, known as generalized second law of thermodynamics(GSLT). Here, we have assumed the universe to be bounded by the event-horizon or filled with perfect fluid and holographic dark energy in two cases. Thus considering entropy to be an arbitrary function of the area of the event-horizon, we have tried to find the conditions and the restrictions over the scalar field and equation of state for the validity of the GSLT and both in quintessence-era and in phantom-era in scalar tensor theory.Comment: 8 page

Cosmological Evolution Across Phantom Crossing and the Nature of the Horizon

In standard cosmology, with the evolution of the universe, the matter density and thermodynamic pressure gradually decreases. Also in course of evolution, the matter in the universe obeys (or violates) some restrictions or energy conditions. If the matter distribution obeys strong energy condition (SEC), the universe is in a decelerating phase while violation of SEC indicates an accelerated expansion of the universe. In the period of accelerated expansion the matter may be either of quintessence nature or of phantom nature depending on the fulfilment of the weak energy condition (WEC) or violation of it. As recent observational evidences demand that the universe is going through an accelerated expansion so mater should be either quintessence or phantom in nature. In the present work we study the evolution of the universe through the phantom barrier (i.e. the dividing line between the quintessence and phantom era) and examine how apparent and event horizon change across the barrier. Finally, we investigate the possibility of occurrence of any singularity in phantom era.Comment: 7 pages and 4 figure

Physicochemical characterization and in vitro dissolution studies of solid dispersions of ketoprofen with PVP K30 and d-mannitol

AbstractAim of the present study was to improve the solubility and dissolution rate of poorly water soluble, BCS class-II drug Ketoprofen (KETO) by solid-dispersion approach. Solid dispersions were prepared by using polyvinylpyrrolidone K30 (PVP K30) and d-mannitol in different drugs to carrier ratios. Dispersions with PVP K30 were prepared by kneading and solvent evaporation techniques, whereas solid dispersions containing d-mannitol were prepared by kneading and melting techniques. These formulations were characterized in the liquid state by phase-solubility studies and in the solid state by Differential Scanning Calorimetry (DSC), Fourier Transform Infrared (FTIR) spectroscopy, X-ray diffraction (XRD) and Scanning Electron Microscopy (SEM). The aqueous solubility of KETO was favored by the presence of both carriers. The negative values of Gibbs free energy illustrate the spontaneous transfer from pure water to the aqueous polymer environment. Solid state characterization indicated KETO was present as fine particles in d-mannitol solid dispersions and entrapped in carrier matrix of PVP K30 solid dispersions. In contrast to the very slow dissolution rate of pure KETO, dispersions of drug in carriers considerably improved the dissolution rate. This can be attributed to increased wettability and dispersibility, as well as decreased crystallinity and increase in amorphous fraction of drug. Solid dispersions prepared with PVP K30 showed the highest improvement in dissolution rate of KETO. Even physical mixtures of KETO prepared with both carriers also showed better dissolution profiles than those of pure KETO