Signaling pathways in osteogenesis and osteoclastogenesis: Lessons from cranial sutures and applications to regenerative medicine.

One of the simplest models for examining the interplay between bone formation and resorption is the junction between the cranial bones. Although only roughly a quarter of patients diagnosed with craniosynostosis have been linked to known genetic disturbances, the molecular mechanisms elucidated from these studies have provided basic knowledge of bone homeostasis. This work has translated to methods and advances in bone tissue engineering. In this review, we examine the current knowledge of cranial suture biology derived from human craniosynostosis syndromes and discuss its application to regenerative medicine

Properties of the stochastic Gross-Pitaevskii equation: Projected Ehrenfest relations and the optimal plane wave basis

We investigate the properties of the stochastic Gross-Pitaevskii equation describing a condensate interacting with a stationary thermal cloud derived by Gardiner and coworkers. We find the appropriate Ehrenfest relations for the SGPE, including the effect of growth noise and projector terms arising from the energy cutoff. This is carried out in the high temperature regime appropriate for the SGPE, which simplifies the action of the projectors. The validity condition for neglecting the projector terms in the Ehrenfest relations is found to be more stringent than the usual condition of validity of the truncated Wigner method or classical field method -- which is that all modes are highly occupied. In addition it is required that the overlap of the nonlinear term with the lowest energy eigenstate of the non-condensate band is small. We show how to use the Ehrenfest relations along with the corrections generated by the projector to monitor dynamical artifacts arising from the cutoff. We also investigate the effect of using different bases to describe a harmonically trapped BEC at finite temperature by comparing the condensate fraction found using the plane wave and single particle bases. We show that the equilibrium properties are strongly dependent on the choice of basis. There is thus an optimal choice of plane wave basis for a given cut-off energy and we show that this basis gives the best reproduction of the single particle spectrum, the condensate fraction and the position and momentum densities.Comment: 23 pages, 5 figure

Mumford dendrograms and discrete p-adic symmetries

In this article, we present an effective encoding of dendrograms by embedding them into the Bruhat-Tits trees associated to $p$-adic number fields. As an application, we show how strings over a finite alphabet can be encoded in cyclotomic extensions of $\mathbb{Q}_p$ and discuss $p$-adic DNA encoding. The application leads to fast $p$-adic agglomerative hierarchic algorithms similar to the ones recently used e.g. by A. Khrennikov and others. From the viewpoint of $p$-adic geometry, to encode a dendrogram $X$ in a $p$-adic field $K$ means to fix a set $S$ of $K$-rational punctures on the $p$-adic projective line $\mathbb{P}^1$. To $\mathbb{P}^1\setminus S$ is associated in a natural way a subtree inside the Bruhat-Tits tree which recovers $X$, a method first used by F. Kato in 1999 in the classification of discrete subgroups of $\textrm{PGL}_2(K)$. Next, we show how the $p$-adic moduli space $\mathfrak{M}_{0,n}$ of $\mathbb{P}^1$ with $n$ punctures can be applied to the study of time series of dendrograms and those symmetries arising from hyperbolic actions on $\mathbb{P}^1$. In this way, we can associate to certain classes of dynamical systems a Mumford curve, i.e. a $p$-adic algebraic curve with totally degenerate reduction modulo $p$. Finally, we indicate some of our results in the study of general discrete actions on $\mathbb{P}^1$, and their relation to $p$-adic Hurwitz spaces.Comment: 14 pages, 6 figure

Estimation and optimal designing under latent variable models for paired comparisons studies via a multiplicative algorithm

We consider:<BR/> 1. The problem of estimating the parameters of latent variable models such as the Bradley Terry or Thurstone Model by the method of maximum likelihood, given data from a paired comparisons experiment. The parameters of these models can be taken to be weights which are positive and sum to one;<BR/> 2. The problem of determining approximate locally optimal designs for good estimation of these parameters; i.e of determining optimal design weights which are also positive and sum to one

A NOVEL BEDSIDE COMMUNICATION TOOL

Effective communication between patients, their families, their carers and health care professionals is paramount to the delivery of high quality care. Addressing the ideas, concerns and expectations of these groups may improve their healthcare experience. We propose that opening a new channel of communication between patients, families, carers and healthcare professionals on the wards would improve the delivery of healthcare. We present a novel written communication aid- the Care Communication Aid (CCA), with preliminary data from secondary and tertiary healthcare trials demonstrating its efficacy and shortcomings, and the reaction of both recipients and providers of healthcare to this novel approach

Ground-State Properties of a Rotating Bose-Einstein Condensate with Attractive Interaction

The ground state of a rotating Bose-Einstein condensate with attractive interaction in a quasi-one-dimensional torus is studied in terms of the ratio $\gamma$ of the mean-field interaction energy per particle to the single-particle energy-level spacing. The plateaus of quantized circulation are found to appear if and only if $\gamma<1$ with the lengths of the plateaus reduced due to hybridization of the condensate over different angular-momentum states.Comment: 4 pages, 2 figures, Accepted for publication in Physical Reveiw Letter

Suppression of Kelvon-induced decay of quantized vortices in oblate Bose-Einstein Condensates

We study the Kelvin mode excitations on a vortex line in a three-dimensional trapped Bose-Einstein condensate at finite temperature. Our stochastic Gross-Pitaevskii simulations show that the activation of these modes can be suppressed by tightening the confinement along the direction of the vortex line, leading to a strong suppression in the vortex decay rate as the system enters a regime of two-dimensional vortex dynamics. As the system approaches the condensation transition temperature we find that the vortex decay rate is strongly sensitive to dimensionality and temperature, observing a large enhancement for quasi-two-dimensional traps. Three-dimensional simulations of the recent vortex dipole decay experiment of Neely et al. [Phys. Rev. Lett. 104, 160401 (2010)] confirm two-dimensional vortex dynamics, and predict a dipole lifetime consistent with experimental observations and suppression of Kelvon-induced vortex decay in highly oblate condensates.Comment: 8 pages, 8 figure