23 research outputs found

    Paroxysmal and persistent atrial fibrillation ablation outcomes with the pulmonary vein ablation catheter GOLD duty-cycled phased radiofrequency ablation catheter: Quality of life and 12-month efficacy results from the GOLD Atrial Fibrillation Registry

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    Aims: The GOLD AF Registry has been designed to prospectively assess the population, indications, and outcomes using second-generation phased radiofrequency (RF) ablation (pulmonary vein ablation catheter GOLD) in a global examination of standard-of-care use for the treatment of paroxysmal and persistent atrial fibrillation (AF). Methods and results: GOLD AF (NCT02433613) is a prospective, observational, multi-centre registry designed to characterize efficacy and safety of phased RF ablation in patients with AF. The primary endpoint was freedom from AF recurrence at 12-month follow-up after a 90-day blanking period. Ancillary objectives include safety, procedural efficiency, and quality of life (QoL). The QoL assessment using the Atrial Fibrillation Effect on QualiTy-of-Life (AFEQT) and the European Heart Rhythm Association (EHRA) Score of AF-related symptoms was collected at baseline and 12 months. In total, 1054 patients were included in this analysis (age 60.6, 67.6% male, 26.5% PersAF). Kaplan-Meier estimate of freedom from AF recurrence was 77.7% at 12 months. Peri-procedural device or procedure-related complications were observed in 26 (2.5%) patients, with a low stroke rate of 0.3%. One-year post-ablation, the EHRA AF Symptom score decreased in 68% of patients. The AFEQT score improvement was observed in 88.4% and 90.4% of patients who completed the questionnaire in-person or interviewed by phone at 12 month follow-up, respectively. Conclusion: Phased RF ablation for the treatment of paroxysmal and persistent AF demonstrated a 77.7% freedom from AF recurrence at 12 months in addition to a significant reduction in arrhythmia symptoms and clinically meaningful improved QoL. Low peri-procedural complication rate of <3% was reported

    Embodied learning in vocational education and training

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    Researchers investigating learning from primary to higher education have emphasised the crucial role of embodiment in the process of developing knowledge, skills and expertise. In spite of this, the physical or psychomotor aspects of learning are vastly under-researched and undervalued in the literature on vocational education and training (VET). Such a marginalisation of embodiment and the physical is regrettable in that – in addition to its failure to sufficiently acknowledge defining features of much vocational learning – it serves to reinforce the notion that only the cognitive aspects of learning are of interest and value in vocational development. Such a partial and misguided conception contributes to the subordinate and second-class status of vocational studies against liberal/academic pursuits. It will be argued here that a re-examination of the role of the physical in VET can provide – not just a richer and deeper understanding of vocational learning – but also a means of enhancing the status of vocational pursuits within general education systems

    ADENINE DERIVATIVES AND THEIR BIOLOGICAL FUNCTIONS

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