19 research outputs found
129Xe NMR study of the homogeneity and the size distribution of small sodium metal particles in NaY zeolite
Skeletal Isomerization of Linear Butenes on Boron Promoted Ferrierite: Effect of the Catalyst Preparation Technique
Influence of Al Distribution and Defects Concentration of Ferrierite Catalysts Synthesized From Na-Free Gels in the Skeletal Isomerization of n-Butene
Skeletal Isomerization of Butene in Ferrierite: Assessing the Energetic and Structural Differences between Carbenium and Alkoxide Based Pathways
Effects of Dimethyl Sulfoxide on Lipid Membrane Electroporation
Pores can be generated in lipid membranes by the application of an external electric field or by the addition of particular chemicals such as dimethyl sulfoxide (DMSO). Molecular dynamics (MD) has been shown to be a useful tool for unveiling many aspects of pore formation in lipid membranes in both situations. By means of MD simulations, we address the formation of electropores in cholesterol-containing lipid bilayers under the influence of DMSO. We show how a combination of physical and chemical mechanisms leads to more favorable conditions for generating membrane pores and, in particular, how the addition of DMSO to the medium significantly reduces the minimum electric field required to electroporate a lipid membrane. The strong alteration of membrane transversal properties and the energetic stabilization of the hydrophobic pore stage by DMSO provide the physicochemical mechanisms that explain this effect.Fil: Fernández, María Laura. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Reigada, Ramón. Universidad de Barcelona; Españ