Daptomycin for the treatment of major gram-positive infections after cardiac surgery

Background: Infection is a main cause of morbidity and mortality after heart surgery, with multi-resistant pathogens increasingly representing a challenge. Daptomycin provides bactericidal activity against gram-positive organisms that are resistant to standard treatment including vancomycin. Methods: A cohort of cardiac surgical patients, treated with daptomycin for major infection at two tertiary care centers, were retrospectively studied with a particular focus on the type of infection, causative pathogens and co-infections, daptomycin dosage, adverse events and outcome in order to provide evidence for the efficiency and safety of daptomycin in a distinct high-risk patient population. Results: Sixty-five patients (87.7 % males, 60.4 +/- 13.5 years) who had undergone aortic surgery (20.0 %), ventricular assist device (VAD) implantation (21.5 %), combined procedures (21.5 %), coronary artery bypass grafting (12.3 %), isolated valve surgery (15.4 %) and heart transplantation (7.7 %) were diagnosed with catheter-related infection (26.1 %), valve endocarditis (18.8 %), sternal wound (13.0 %), VAD-associated (11.6 %), cardiac implantable electrophysiological device (CIED)-associated (4.1 %), respiratory tract (4.3 %), bloodstream (4.3 %) and other infection (4.3 %). In 13.0 %, no focus of infection was identified though symptoms of severe infection were present. The most frequent pathogens were Staphylococcus epidermidis (30.4 %), Staphylococcus aureus (23.1 %) and Enterococcus species (10.1 %). Daptomycin doses ranging from 3 mg/kg every 48 h to 10 mg/kg every 24 h were administered for 15.4 +/- 11.8 days. 87.0 % of the cases were classified as success, 7.2 % as treatment failure and 5.8 as non-evaluable. Adverse events were limited to one case of mild and one case of moderate neutropenia with recovery upon termination of treatment. Conclusion: Daptomycin proved safe and effective in major infection in high-risk cardiac surgical patients

[Culinary ephemera : gelatin and tapioca].

Corporate contributors include: Genesee Pure Food Company; Jell-O-Co. Inc.Item [34] promotes Jell-O. Includes rules for preparing Jell-O and menus, recipes, table service, and illustrations of guests in period dress and serving suggestions for different occasions. Sample recipes: asparagus salad, chocolate walnut Jell-O, and baked apple de luxe. Damaged: left back cover detached. Exhibitable.Item [33] promotes Jell-O. Includes description and illustrations of marketing around the world for Jell-O ingredients; world map, and illustrations of Jell-O factory in Le Roy, New York, Jell-O machine, and Jell-O girl. No recipes. 2 copies. Exhibitable.Item [32] promotes Jell-O. Includes illustrations by Marion Powers of serving suggestions with appropriate backgrounds suggesting different countries; menus and recipes; and product packaging illustration. Sample recipes: macaroni salad, cream fig pudding, and banana sauce. Marked: 4894. 4 copies.Item [31] promotes Jell-O. Includes rules for using Jell-O; recipes; serving suggestion and product packaging illustrations; cover illustrations by Linn Ball of woman and children in period dress; offer of circular about D-Zerta, a sugar-free jelly powder similar to Jell-O; and loose insert on Jell-O Ice Cream Pudding. Sample recipes: camp fire pudding, Jell-O in quarter oranges, and nut frappé. 2 copies.Item [30] promotes Jell-O and Jell-O Ice Cream Powder. Includes 6 brochures promoting Jell-O, 2 partial brochures for Jell-O, and one booklet promoting Jell-O Ice Cream Powder, all with recipes and serving suggestion illustrations. Sample recipes: plum pudding ice cream, Mrs. Rorer's coupe Santa Marie, and cardinal salad.Item [29] promotes Jell-O. Includes same front cover illustration and some internal illustrations as in item [22]; menus and recipes; serving suggestion and product packaging illustrations; and loose insert for Jell-O ice cream powder. Sample recipes: prune whip, Jell-O and raspberry jam, and maple walnut Jell-O. 2 copies.Item [28] promotes Jell-O. Includes illustrations of Miss Jell-O in Irish costume and serving suggestion; tips for using Jell-O; nutritional information; and 4 recipes. Sample recipe: paradise pudding.Item [27] promotes Jell-O. Includes illustrations of Miss Jell-O in Chinese costume and serving suggestion; tips for using Jell-O; nutritional information; and 5 recipes. Sample recipe: banana cream.Item [26] is similar to item [25] except for title and front cover illustration. 2 copies. Exhibitable.Item [25] promotes Jell-O. Includes illustrations by Rose O'Neill of Jell-O girl preparing for and at a party for her friends; advice for children giving a party; product packaging and serving suggestion illustrations; illustrated directions for a child's daily exercises; descriptions of children's games; table settings for a variety of occasions; and loose Jell-O Ice Cream Powder insert. Sample recipes: imperial salad, strawberry brick, and loganberry Jell-O. 2 copies. Exhibitable.Item [24] promotes Jell-O. Includes hints using Jell-O; an illustration of the Jell-O girl for each month of the year; Jell-O recipes; product packaging and serving suggestion illustrations; and loose Jell-O Ice Cream Powder insert. Sample recipes: grape juice frappé, lemon sherbet, and beauty salad. 2 items.Item [23] promotes Jell-O. Includes cover illustration by Maxfield Parrish of "Polly put the kettle on"; nutritional content of Jell-O; recipes and menus using Jell-O; and illustrations of factory, Jell-O packing machine, product packaging, and serving suggestions. Sample recipes: California special, Jell-O birthday cake, and Spanish jell-O salad.Item [22] promotes Jell-O. Includes cover illustrations of man trying to recover box of Jell-O packages dropped on train tracks before train crushes box and of grandparents and grandchild at home; recipes; illustrations of children in period dress, product packaging, and serving suggestions; and Jell-O Ice Cream Powder insert. Sample recipes: paradise pudding, strawberry brick, and sweet pickle relish. 2 copies.Item [21] promotes Jell-O. Edited by Caroline B. King and illustrated by Lucile Patterson Marsh. Includes illustrations of familiar nursery rhymes with words adapted to mention Jell-O; directions for whipping Jell-O; recipes for children, convalescents, luncheon, and dinner; Jell-O Ice Cream Powder insert; and product packaging and serving suggestion illustrations. Sample recipes: maple cream filling for cake, Marion Harland's prune whip, and tuna fish salad. 2 copies.Item [20] promotes Jell-O. Includes cover illustrations by Norman Rockwell of grandmother making Jell-O with grandchildren and child serving Jell-O to her doll; introduction by Alice Bradley, principal of Miss Farmer's School of Cookery; illustrated step-by-step instructions ("moving pictures") for making plain Jell-O, layer Jell-O, whipped Jell-O, and fruited Jell-O; additional recipes; and product packaging and serving suggestion illustrations. Sample recipes: Jell-O and baked apples, beauty salad, and ginger ale salad. 2 copies.Item [19] promotes Jell-O. Includes illustrations of bear outside mountain chalet on cover, cattle country, picnic in redwoods, Eskimos under northern lights, mission country, plantation home, prairie luncheon for the workers, and New England home in the woods all by Angus MacDonall, product packaging, and serving suggestions; recipes some of which are attributed; and Jell-O Ice Cream Powder insert. Sample recipes: pineapple Bavarian cream, mocha charlotte, and Jell-O horseradish relish. 3 copies. Exhibitable.Item [18] promotes Jell-O. Includes cover illustration of girl holding basket of fruit and Jell-O packages. Content similar to that of item [17]. 2 copies.Item [17] promotes Jell-O. Includes cover illustration of woman sitting at table with account book; reasons for using Jell-O; recipes; product packaging and serving suggestion illustrations; illustrated description of Jell-O safety bag; and insert on Jell-O Ice Cream Powder. Sample recipes: snow pudding, glorified rice, and cucumber salad.Item [16] promotes Jell-O. Includes cover illustration of young girl writing letters; recipes for desserts and salads; illustrated description of teaching of Jell-O uses in domestic science schools; product packaging and serving suggestion illustrations; and insert on Jell-O Ice Cream Powder. Sample recipes: Valentine Day hearts, plum pudding, and grapefruit salad. 2 copies.Item [15] promotes Jell-O. Includes illustrations of young girl opening door from garden on cover, the actress Ethel Barrymore, Marion Harland, Rose O'Neill, the singer Madame Schumannheink, product packaging, and serving suggestions; testimonials from and biographies of illustrated women; recipes; insert on Jell-O Ice Cream Powder; and illustrated description of Jell-O safety bag included in Jell-O package. Sample recipes: grape juice frappé, flaked ambrosia, and imperial salad. 2 copies. Exhibitable.Item [14] promotes Jell-O. Includes illustrations of bride and an attendant on cover and six famous cooks, Mrs. Hill, Mrs. Herrick, Mrs. Rorer, Mrs. Lincoln, Marion Harland, and Mrs. Telford; advice to bride on feeding her new husband, her parents, her baby, unexpected visitors, and old school friends and giving a birthday party for her husband; illustrations of period dress, product packaging, and serving suggestions; and insert on Jell-O Ice Cream Powder. Sample recipes: Mrs. Lincoln's strawberry mousse, Roman sponge, and peach whip. 2 copies.Item [13] promotes Jell-O. Includes illustrations by Rose O'Neill, illustrator of Jell-O advertisements for several years; illustrations of six famous cooks, Mrs. Hill, Mrs. Herrick, Mrs. Rorer, Mrs. Lincoln, Marion Harland, and Mrs. Telford, period dress, and Kewpies, impish babies created by Rose O'Neill; instructions for using Jell-O; remark that despite war Jell-O has not increased in price; recipes including some by cooks named above; illustrations of product packaging and serving suggestions; and insert advertising Jell-O Ice Cream Powder. Sample recipes: macaroon velvet Jell-O, Mrs. Rorer's coupé Santa Marie, and Delmonico dessert. 2 copies. Exhibitable.Item [12], produced in Canada, promotes Jell-O Ice Cream Powder. Includes instructions for making ice cream from Jell-O Ice Cream Powder; ice cream, sherbet, ice, and pudding recipes; illustrations of couple in period dress on cover, product packaging, and serving suggestions; and offer (in French) to send copy of item in French. Sample recipes: orange cream and fig pudding.Item [11] promotes Jell-O. Includes remarks on the ease of using Jell-O and the unlikelihood of a failure using it; illustrations of mother and daughter on cover with girl in dress-up clothes, factory encased in Jell-O, product packaging, and serving suggestions; and loose insert advertising Jell-O Ice Cream Powder. Images include racial caricature of African-American woman. Sample recipes: lemon Jell-O syllabub, date dessert, and banana cream. 2 copies. Exhibitable.Item [10] promotes Jell-O. Includes testimonials by, illustrations of, and recipes by Marian Harland, Sarah Tyson Rorer, Mary J. Lincoln, Janet McKenzie Hill, Emma Paddock Telford, and Christine Terhune Herrick; illustrations of period dress, product packaging, and serving suggestions; mention of gold medals won in 1904, 1905, 1907, and 1909; and loose insert advertising Jell-O Ice Cream Powder. Sample recipes: raspberry Jell-O supreme, Manhattan salad, and chocolate bavaroise. 2 copies.Item [9] promotes Jell-O. Includes recipes by Sarah Tyson Rorer, Mary J. Lincoln, Emma Paddock Telford, and Janet McKenzie Hill; illustrations of period dress, product packaging, and serving suggestions; and loose insert advertising Jell-O Ice Cream Powder. Sample recipes: Mrs. Rorer's Bavarian cream, mint Jell-O, and pimento Jell-O salad. 2 copies. Exhibitable.Item [8] promotes Jell-O and Jell-O Ice Cream Powder. Includes illustrations of people in period dress on telephone mentioning Jell-O recipes; Jell-O recipes; illustrations of product packaging and serving suggestions; and mention of gold medals won be Jell-O at expositions of 1904, 1905, 1907, and 1909. Images include racial caricature of African-American woman. Sample recipes: apple snow Jell-O, pineapple trifle, and marshmallow Jell-O. Exhibitable.Item [7] promotes Jell-O. Includes descriptions of desserts in different cultures with appropriate illustrations of mealtime; recipes for Jell-O desserts; and illustrations of period dress, product packaging, and serving suggestions; and mention of gold medals won be Jell-O at expositions of 1905, 1904, and 1907. Some recipes use wine as an ingredient. Sample recipes: fruited Jell-O, peach snow, and Neapolitan Jell-O. 2 copies. Exhibitable.Item [6] promotes Jell-O. Includes illustrated directions for making Jell-O; Jell-O recipes: illustrations of children in period dress, product packaging, and serving suggestions; and mention of gold medals won by Jell-O at expositions of 1905, 1904, and 1907. Sample recipes: pineapple trifle, coffee Jell-O, and lemon oval.Item [5] promotes Jell-O. Compiled by Mrs. Nellie Duling Gans (principal of Chicago Cooking College,) includes recipes contributes by her and Mrs. E. Luchting; advertisements for Jell-O and Jell-O Ice Cream Powder; illustrations of girl in period dress, product packaging, and serving suggestions. Sample recipes: cherry charlotte, nut frappe, and apple flip.Item [4] promotes Jell-O Ice Cream Powder. Includes recipes for ice cream and puddings; directions for freezing; advertisement for White Mountain Freezer and fancy jelly moulds; and period dress, product packaging and serving suggestion illustrations. Sample recipes: strawberry custard, frozen souffle, and nesselrode pudding.Item [3] promotes Jell-O. Includes 38 recipes; advertisement for Jell-O Ice Cream Powder; and product packaging and serving suggestion illustrations. Some recipes include wine as an ingredient. Sample recipes: orange baskets, moulded tomatoes, and wine Jell-O. 2 copies marked 5-23-04-2MM and 10-10-04-3MM, respectively.Item [2] promotes Jell-O. Designed to look like product package with front torn to reveal illustration of girl in period dress holding dish of strawberry Jell-O. No recipes: Marked: F-300-11-10-02-6000 M.Item [1] promotes Jell-O. Includes 16 brochures, each with rules for using Jell-O, several Jell-O recipes, nutrition information, and serving suggestion illustrations, from 5 different series: nos. 5, 7, 8, and 11 of series with title Jell-O America's most famous dessert; January, February, June, September, November, and December of Jell-O girl series with illustrations of girl in period dress; nos. 1, 2, 5, and 6 of Fairy tale series; no. 8 in series of Jell-O girl in foreign countries; and no. 10 of nursery rhyme series. Sample recipes: Spanish Jell-O salad, loganberry Jell-O, and paradise pudding.[31]. New Jell-O recipes. 18 p. -- [32]. Jell-O, America's most famous dessert. 18 p. -- [33]. Miss Jell-O tells the what and how of America's most famous dessert : [folded brochure]. -- [34]. The charm of Jell-O. 32 p.[21]. Jell-O rhymes. 19 p. -- [22]. [America's most famous dessert Jell-O.] 18 p. -- [23]. Polly put the kettle on, we'll all make Jell-O. 18 p. -- [24]. 1924, a Jell-O year. 14 p. -- [25]. The Jell-O girl entertains. 15 p. -- [26]. The Jell-O girl gives a party. 15 p. -- [27]. Miss Jell-O visits China : [folded brochure]. -- [28]. Miss Jell-O in Ireland : [folded brochure]. -- [29]. [Jell-O recipe book.] 18 p. -- [30]. [Jell-O recipe brochures]. --[11]. Jell-O, America's most famous dessert. 15 p. -- [12]. Jell-O Ice Cream Powder. [8] p. -- [13]. Jell-O and the Kewpies. 18 p. -- [14]. Jell-O, America's most famous dessert. 18 p. -- [15]. All doors open to Jell-O, America's most famous dessert. 18 p. -- [16]. New talks about Jell-O, America's most famous dessert. 14 p. -- [17]. For economy use, Jell-O, America's most famous dessert. 14 p. -- [18]. Many reasons for Jell-O, America's most famous dessert. 14 p. -- [19]. Jell-O, America's most famous dessert, at home everywhere. 14 p. -- [20]. "It's so simple" Jell-O, America's most famous dessert. 14 p. --[1]. [Jell-O recipe brochures]. -- [2]. [Jell-O brochure]. -- [3]. Jell-O. 1 v. (unpaged) -- [4]. Jell-O Ice Cream Powder. 1 v. (unpaged) -- [5]. Jell-O for dessert. 1 v. (unpaged) -- [6]. They wanted Jell-O. 1 v. (unpaged) -- [7]. Desserts of the world. 1 v. (unpaged) -- [8]. Hello? Jell-O, the dainty dessert. 1 v. (unpaged) -- [9]. Jell-O, America's most famous dessert. 14 p. -- [10]. What six famous cooks say of Jell-O. 14 p. --Mode of access: Internet.Grey Hollinger box.ACQ: 35669; 35992