Greetings from Governor Arthur B. Langlie

President Nichoson, Officers, and Members of the State Bar and Bench. I always enjoy fellowship with my fellow members of the Bar and am particularly happy to be here with you today I know that many of you are here to talk shop, and perhaps the things I would like to discuss with you today may seem to some of you a little off the beaten path for which you traveled over here, but I cannot overlook the opportunity, as Governor, to talk with men and women that I feel must exercise a tremendous influence upon the people of our state, and in these times that influence is particularly important

Address by Arthur B. Langlie, Governor of the State of Washington

Today I hope to take a little of your time, rather than try to extend some complimentary greeting of some kind or another, I would like to take this opportunity to talk a little bit about our government, our state government, some of its problems, primarily its tax problems, because some of you may have noted already that while the law has not become effective as yet, that there is going to be a slight tap on your personal income in the way of an increase in the business and occupational tax, and I want to talk to you about it because, in these days of increasing costs in all areas of activity, I think it is necessary to understand that government has some of the same problems during the period of inflation that the private citizen has. While we strive in government to reduce costs where we can, there are some limitations upon our ability to do so, and I think it is necessary for the people generally to have an appreciation of what the government is up against

Address by Arthur B. Langlie, Governor of the State of Washington

I always enjoy coming here, because it brings me back to the delightful days when I had a chance to associate with you more intimately. I am glad to be here today to express my thanks to the Bar Association of this State for the excellent cooperation that I have had, while serving as your Governor, in the matter of filling vacancies in our Judicial positions. While there were some contests in that area, at the present time, in the main, the people have expressed extreme confidence in your recommendations and there has been little opposition of many of the posts that have been filled. I feel that with your help the Bench has been strengthened and that we can continue to improve our administration of justice and our techniques in the judicial end of our businesses to the extent that the people of the State will benefit

Letter from Arthur B. Langlie

Langlie supports the Clearwater dams and the flood control benefits they will brin

Recent advancements in cell-based models for auditory disorders

Introduction: Cell-based models play an important role in understanding the pathophysiology and etiology of auditory disorders. For the auditory system, models have primarily focused on restoring inner and outer hair cells. However, they have largely underrepresented the surrounding structures and cells that support the function of the hair cells. Methods: In this article, we will review recent advancements in the evolution of cell-based models of auditory disorders in their progression towards three dimensional (3D) models and organoids that more closely mimic the pathophysiology in vivo. Results: With the elucidation of the molecular targets and transcription factors required to generate diverse cell lines of the components of inner ear, research is starting to progress from two dimensional (2D) models to a greater 3D approach. Of note, the 3D models of the inner ear, including organoids, are relatively new and emerging in the field. As 3D models of the inner ear continue to evolve in complexity, their role in modeling disease will grow as they bridge the gap between cell culture and in vivo models. Conclusion: Using 3D cell models to understand the etiology and molecular mechanisms underlying auditory disorders holds great potential for developing more targeted and effective novel therapeutics

Unraveling pathological mechanisms in neurological disorders: the impact of cell-based and organoid models

Cell-based models are a promising tool in deciphering the molecular mechanisms underlying the pathogenesis of neurological disorders as well as aiding in the discovery and development of future drug therapies. The greatest challenge is creating cell-based models that encapsulate the vast phenotypic presentations as well as the underlying genotypic etiology of these conditions. In this article, we discuss the recent advancements in cell-based models for understanding the pathophysiology of neurological disorders. We reviewed studies discussing the progression of cell-based models to the advancement of three-dimensional models and organoids that provide a more accurate model of the pathophysiology of neurological disorders in vivo. The better we understand how to create more precise models of the neurological system, the sooner we will be able to create patient-specific models and large libraries of these neurological disorders. While three-dimensional models can be used to discover the linking factors to connect the varying phenotypes, such models will also help to understand the early pathophysiology of these neurological disorders and how they are affected by their environment. The three-dimensional cell models will allow us to create more specific treatments and uncover potentially preventative measures in neurological disorders such as autism spectrum disorder, Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis