10 research outputs found
Chronic air pollution and social deprivation as modifiers of the association between high temperature and daily mortality
Mining care trajectories using health administrative information systems: the use of state sequence analysis to assess disparities in prenatal care consumption
Does the edge effect impact on the measure of spatial accessibility to healthcare providers?
Inégalités sociales vis-à -vis de la létalité consécutive à un accident vasculaire cérébral, Dijon, France
International audienceContexte.â Plusieurs Ă©tudes ont mis en Ă©vidence lâaugmentation de la mortalitĂ© post accident vasculaire cĂ©rĂ©bral (AVC) Ă mesure que le niveau socioĂ©conomique du voisinage diminue. Nous avons examinĂ© si ce dĂ©savantage concernait lâensemble ou bien une pĂ©riode spĂ©cifique de la prise en charge.MĂ©thode.â La population dâĂ©tude comprend tous les cas incidents dâAVC identifiĂ©s par le registre dijonnais des AVC entre 1998 et 2010. Nous avons classĂ© les patients en terciles de niveau de dĂ©faveur sur la base du score de Townsend de leur quartier de rĂ©sidence. Ă lâaide du modĂšle de Cox, nous avons dâabord analysĂ© la lĂ©talitĂ© sur lâensemble de la pĂ©riode de suivi (jusquâĂ 90 jours post-AVC), puis distinguĂ© la pĂ©riode de prise en charge initiale et la pĂ©riode post hospitalisation aiguĂ«.RĂ©sultats.â Notre Ă©chantillon comprend 1327 cas incidents dâAVC (Ăąge moyen 75 ans, hommes 49 %) ; 207 patients (15,6 %) sont dĂ©cĂ©dĂ©s au cours du suivi, la plupart Ă lâissue de lâhospitalisation aiguĂ« (163, soit 79 %). Globalement le risque de dĂ©cĂšs augmentait en fonction du niveau de dĂ©faveur : Hazard ratio (HR) 2e versus 1er tercile = 1,33 (IC95 % : 0,95â1,86) ; 3e versus 1er tercile = HR = 1,48 (1,03â2,12) (tendance, p = 0,03). Si aucune tendance significative nâĂ©tait dĂ©tectable lors de la prise en charge hospitaliĂšre aiguĂ«, un gradient prononcĂ© existait au-delĂ de cette pĂ©riode : 2e versus 1er tercile = HR = 1,48 (0,54â4,08), 3e versus 1er tercile = HR = 3,08 (1,17â8,13) (tendance, p = 0,002). Ce gradient persistait aprĂšs ajustement pour le type et la sĂ©vĂ©ritĂ© de lâAVC.Conclusion.â La prise en charge aiguĂ« ne semble pas ĂȘtre en cause dans la genĂšse des inĂ©galitĂ©s sociales vis-Ă -vis de la lĂ©talitĂ© post-AVC. Ces inĂ©galitĂ©s rĂ©sultent sans doute dâautres dĂ©terminants soit individuels, contextuels ou encore relatifs aux soins situĂ©s plus en aval dans la prise en charge
A Canadian Neighbourhood Index for Socioeconomic Status Associated with Early Child Development
Zebra Finch chicks recognise parental scent, and retain chemosensory knowledge of their genetic mother, even after egg cross-fostering
Serum and lymphocytic neurotrophins profiles in systemic lupus erythematosus: a case-control study.
BACKGROUND: Neurotrophins play a central role in the development and maintenance of the nervous system. However, neurotrophins can also modulate B and T cell proliferation and activation, especially via autocrine loops. We hypothesized that both serum and lymphocytic neurotrophin levels may be deregulated in systemic Lupus erythematosus (SLE) and may reflect clinical symptoms of the disease. METHODS: Neurotrophins in the serum (ELISA tests) and lymphocytes (flow cytometry) were measured in 26 SLE patients and 26 control subjects. Th1 (interferon-Îł) and Th2 (IL-10) profiles and serum concentration of BAFF were assessed by ELISA in the SLE and control subjects. FINDINGS: We have demonstrated that both NGF and BDNF serum levels are higher in SLE patients than healthy controls (p=0.003 and p<0.001), independently of Th1 or Th2 profiles. Enhanced serum NT-3 levels (p=0.003) were only found in severe lupus flares (i.e. SLEDAI â„ 10) and significantly correlated with complement activation (decreased CH 50, Î=-0.28, p=0.03). Furthermore, there was a negative correlation between serum NGF levels and the number of circulating T regulatory cells (Î=0.48, p=0.01). In circulating B cells, production of both NGF and BDNF was greater in SLE patients than in healthy controls. In particular, the number of NGF-secreting B cells correlated with decreased complement levels (p=0.05). One month after SLE flare treatment, BDNF levels decreased; in contrast, NGF and NT-3 levels remained unchanged. CONCLUSION: This study demonstrates that serum and B cell levels of both NGF and BDNF are increased in SLE, suggesting that the neurotrophin production pathway is deregulated in this disease. These results must be confirmed in a larger study with naive SLE patients, in order to avoid the potential confounding influence of prior immune-modulating treatments on neurotrophin levels