Surface layer composition of titania produced by various methods: the change of layer state under illumination

The comparative analysis of experimental data over titanium dioxide powders prepared by various ways under ambient air is carried out. The results over TiO2 prepared by high-temperature heating of anatase, produced by burning of titanium micro particles and grinding of rutile crystal are used for that comparison. Water and carbon dioxide were the main products released from the surface of the titania powders. It was found that under UV irradiation absorbed by titania, in absent oxygen, water effectively reacts with lattice oxygen of titanium dioxide

Epidemiological characteristics disease outbreakof mycoplasma pneumonia outbreak in an industrial city

The article presents the results of epidemiological analysis of an outbreak of community-acquired pneumonia among the population living in a large industrial city of the Sverdlovsk region (Verkhnyaya Salda city district). The analysis revealed the main age and socio-professional risk groups, the peculiarity of the epidemic foci, and the leading pathogen.В статье представлены результаты эпидемиологического анализа вспышки внебольничной пневмонии среди населения, проживающего в крупном промышленном городе Свердловской области (городской округ Верхняя Салда). В ходе анализа выявлены основные возрастные и социально- профессиональные группы риска, особенности эпидемических очагов, ведущий возбудитель

Risk-oriented approach to the prevention of skin mycoses in modern conditions (based on the materials of the patients examination in Ekaterinburg city)

The incidence of dermatomycoses in children in Russian Federation remains at a consistently high level, which leads to the need of studying the epidemic characteristics of these diseases in order to develop and implement a risk-based prevention approach. The article presents modern formation features of epidemic foci of microsporia, trichophytia in children on the base of a large industrial city with active migration flows.Заболеваемость дерматомикозами детей в Российской Федерации сохраняется на стабильно высоком уровне, что ведет к необходимости изучения эпидемических особенностей этих заболеваний для разработки и внедрения риск-ориентированного подхода к профилактике. В статье представлены современные особенности формирования эпидемических очагов микроспории, трихофитии у детей в крупном промышленном городе с активными миграционными потокам

Clinical specificity of enterovirus meningitidis in children

The article presents specifics of signs and symptoms, as well as some (epidemiological) and diagnostic details of enterovirus meningitidis in a group of children from 3 to 14 years old based on the analysis of medical records of patients hospitalised in the infectious disease ward №6 of the CCH №40 of Ekaterinburg in the summer of 2019.В настоящей статье рассмотрены особенности клинической картины, а также некоторые эпидемиологические и диагностические особенности энтеровирусного менингита у детей в возрасте от 3 до 14 лет на основе анализа историй болезни пациентов, госпитализированных в 6 инфекционное отделение МАУ «ГКБ №40» г.Екатеринбурга в летний период 2019 года

Непроникающая глубокая склерэктомияс имплантацией коллагенового дренажа в хирургическом лечении глаукомы

PURPOSE. Analysis of the results of surgical treatment of glaucoma by non-penetrating deep sclerectomy (NPDS) combined with suprachoroidal implantation of collagen drainage.METHODS. This open prospective study included a total of 98 patients (104 eyes), 45 men and 53 women with primary open-angle glaucoma who were examined and operated on. All patients underwent non-penetrating deep sclerectomy with implantation of the "Xenoplast" drainage. Group I (n=72) consisted of patients without suprachoroidal drainage, and Group II (n=32) — patients who were implanted the drainage. Group I included 15 cases (20.8%) with stage I glaucoma, 17 (23.6%) — stage II, 38 (52.8%) — stage III and 2 (2.8%) — stage IV. Group II patients had stage I glaucoma in 8 cases (25%), stage II in 5 (15.6%), stage III in 17 (53.1%) and stage IV in 2 cases (6.3%). The mean age of study patients was 68.2±7.4 years.RESULTS. All early postoperative complications were transient. There were no significant differences in the frequency of complications between the two groups (p>0.05). In group I patients, Descemet’s goniopuncture was performed significantly more frequently than in group II (p<0.05). No complications were detected in the late postoperative period. Pronounced hypotensive effect wasobserved in both groups on the first day after the operation, IOP in group I was slightly lower and amounted to 15.5±2.3 mm Hg in comparison with 17.3±2.5 mm Hg in group II (p>0.05). Further, after 7 days and 1 month, we observed a slight increase of IOP in group I up to 17.2±2.0 mm Hg, while in Group II it remained practically unchanged. After 1 and 2 years of observation, a respective increase of the mean IOP to 18.5±2.8 and 17.8±2.6 mm Hg was registered in group I. Group II, on the contrary, showed a decrease in IOP in these periods to 16.8±1.9 and 16.2±1.8 mm Hg, respectively (differences between the groups were not statistically significant, p>0.05). In group I, the mean number of instillations used to achieve target IOP was 0.89±0.27; in group II it was 0.83±0.26 (p>0.05). The rate of achieving "complete" success after 6 months and 2 years of observation in groups I and II did not differ significantly and was 94.4% and 90.6%, 65.3% and 59.4%, respectively (p>0.05).CONCLUSION. This paper presents a comparative analysis of the results of non-penetrating deep sclerectomy and collagen drainage implantation depending on the involvement of the suprachoroidal space in the operation with 24 months follow-up. Both groups were comparable in the majority of studied parameters, except for the frequency of laser Descemet’s goniopuncture in the postoperative period (it was significantly lower in the group with suprachoroidal drainage). The proposed technique is effective and safe in the treatment of primary open-angle glaucoma.ЦЕЛЬ. Анализ результатов хирургического лечения глаукомы методом непроникающей глубокой склерэктомии (НГСЭ) в сочетании с супрахориоидальной имплантацией коллагенового дренажа.МЕТОДЫ. Всего в рамках открытого проспективного исследования обследовано и прооперировано 98 пациентов (104 глаза) с первичной открытоугольной глаукомой, из них 45 мужчин и 53 женщины. Всем пациентам проведена НГСЭ с имплантацией дренажа «Ксенопласт». Группу I (n=72) составили пациенты без супрахориоидального дренирования, группу II (n=32) — пациенты, которым такое дренирование проводили. В группе I в 15 случаях (20,8%) определена I стадия глаукомы, в 17 (23,6%) — II стадия, в 38 (52,8%) — III стадия и в 2 (2,8%) — IV стадия. У пациентов группы II в 8 случаях (25%) отмечена I стадия, в 5 (15,6%) — II стадия, 17 (53,1%) — III стадия и в 2 (6,3%) — IV стадия. Средний возраст пациентов составил 68,2±7,4 лет.РЕЗУЛЬТАТЫ. Все ранние послеоперационные осложнения носили транзиторный характер. Достоверных различий в частоте осложнений между двумя группами не выявлено (p>0,05). В группе I десцеметогониопунктуру выполняли значимо чаще, чем в группе II (p<0,05). В позднем послеоперационном периоде осложнений не выявлено. В обеих группах отмечен выраженный гипотензивный эффект через первые сутки после операции, при этом в группе I внутриглазное давление (ВГД) было несколько ниже и составило 15,5±2,3 мм рт.ст по сравнению с 17,3±2,5 мм рт.ст в группе II (p>0,05). В дальнейшем в сроки наблюдения 7 дней и 1 месяц наблюдали увеличение ВГД в группе I до 17,2±2,0 мм рт.ст. В группе II ВГД оставалось неизменным. Через 1 и 2 года наблюдений в группе I отмечено увеличение среднего ВГД до 18,5±2,8 и 17,8±2,6 мм рт.ст, соответственно. В группе II, напротив, отмечено снижение ВГД в указанные сроки до 16,8±1,9 и 16,2±1,8 мм рт.ст, соответственно (различия между группами не были статистически значимыми, p>0,05). В группе I среднее количество используемых в виде инстилляций препаратов для достижения целевого ВГД составило 0,89±0,27, в группе II — 0,83±0,26 (p>0,05). Частота достижения «полного» успеха через 6 месяцев и 2 года наблюдений в группах I и II достоверно не различалась и составила 94,4% и 90,6%; 65,3% и 59,4%, соответственно (p>0,05).ЗАКЛЮЧЕНИЕ. Представлен сравнительный анализ собственных результатов НГСЭ с имплантацией коллагенового дренажа в зависимости от вовлечения в операцию супрахориоидального пространства в срок наблюдения 24 месяца. Исследуемые группы были сопоставимы по большинству исследуемых параметров, за исключением частоты выполнения лазерной десцеметогониопунктуры в послеоперационном периоде (в группе с супрахориоидальным дренированием она была значимо ниже). Предложенная методика является эффективной и безопасной в лечении первичной открытоугольной глаукомы

Uterine leiomyosarcoma and disseminated peritoneal leiomyomatosis in the surgical treatment of uterine myoma: a retrospective analysis

Aim. To analyze the incidence and types of adverse outcomes and complications of laparoscopic myomectomies. Materials and methods. This work is a retrospective study based on data from the Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology. We analyzed 711 case histories of patients diagnosed with uterine myoma who received surgical treatment in the Department of Innovative Oncology and Gynecology from 2015 to 2019. The frequency of malignant neoplasms, verified by pathomorphological examination, and the characteristics of surgical interventions performed in these patients were comparatively evaluated. Results. Surgical interventions for uterine myoma are leading in gynecology due to the high prevalence of such disorders. Conservative myomectomy remains the "gold standard" in organ-sparing surgery. However, during surgeries for suspected benign neoplasms, there is a risk of morcellation of the malignant tumor, significantly worsening patient survival outcomes. In our study, the incidence of uterine leiomyosarcoma in suspected benign neoplasms was 0.98%. The probability of parasitic myomas or disseminated perineal leiomyomatosis after myomatous nodule morcellation is 0.19%. Conclusion. No reliable information about the malignant potential of the tumor and its proliferative activity can be obtained until a definitive pathomorphological examination. The above considerations warrant the routine use of prophylactic measures to prevent tumor cell dissemination

The relationship between fertility and lifespan in humans

Evolutionary theories of aging predict a trade-off between fertility and lifespan, where increased lifespan comes at the cost of reduced fertility. Support for this prediction has been obtained from various sources. However, which genes underlie this relationship is unknown. To assess it, we first analyzed the association of fertility with age at menarche and menopause, and with mortality in 3,575 married female participants of the Rotterdam Study. In addition, we conducted a candidate gene study where 1,664 single nucleotide polymorphisms (SNPs) in 25 candidate genes were analyzed in relation to number of children as a measure of fertility. SNPs that associated with fertility were analyzed for association with mortality. We observed no associations between fertility and age at menarche (p = 0.38) and menopause (p = 0.07). In contrast, fertility was associated with mortality. Women with two to three children had significantly lower mortality (hazard ratio (HR), 0.82; 95% confidence interval (95% CI), 0.69–0.97) compared to women with no children. No such benefit was observed for women with four or more children, who had a similar mortality risk (HR, 0.93; 95% CI, 0.76–1.13) as women with no children. The analysis of candidate genes revealed four genes that influence fertility after correction for multiple testing: CGB/LHB gene cluster (p = 0.0036), FSHR (p = 0.023), FST (p = 0.023), and INHBA (p = 0.021). However, none of the independent SNPs in these genes predicted mortality. In conclusion, women who bear two to three children live longer than those who bear none or many children, but this relationship was not mediated by the candidate genes analyzed in this study