Relativistic precession around rotating neutron stars: Effects due to frame-dragging and stellar oblateness

General relativity predicts that a rotating body produces a frame-dragging (or Lense-Thirring) effect: the orbital plane of a test particle in a non-equatorial orbit precesses about the body's symmetry axis. In this paper we compute the precession frequencies of circular orbits around rapidly rotating neutron stars for a variety of masses and equations of state. The precession frequencies computed are expressed as numerical functions of the orbital frequency observed at infinity. The post-Newtonian expansion of the exact precession formula is examined to identify the relative magnitudes of the precession caused by the Lense-Thirring effect, the usual Newtonian quadrupole effect and relativistic corrections. The first post-Newtonian correction to the Newtonian quadrupole precession is derived in the limit of slow rotation. We show that the post-Newtonian precession formula is a good approximation to the exact precession close to the neutron star in the slow rotation limit (up to \sim 400 Hz in the present context). The results are applied to recent RXTE observations of neutron star low-mass X-ray binaries, which display kHz quasi-periodic oscillations and, within the framework of beat frequency models, allow the measurement of both the neutron star spin frequency and the Keplerian frequency of the innermost ring of matter in the accretion disk around it. For a wide range of realistic equations of state, we find that the predicted precession frequency of this ring is close to one half of the low-frequency (\sim 20 - 35 Hz) quasi-periodic oscillations seen in several Atoll sources.Comment: 35 pages including 10 figures and 6 tables. To appear in the Astrophysical Journa

Hydrostatic Expansion and Spin Changes During Type I X-Ray Bursts

We present calculations of the spin-down of a neutron star atmosphere due to hydrostatic expansion during a Type I X-ray burst. We show that (i) Cumming and Bildsten overestimated the spin-down of rigidly-rotating atmospheres by a factor of two, and (ii) general relativity has a small (5-10%) effect on the angular momentum conservation law. We rescale our results to different neutron star masses, rotation rates and equations of state, and present some detailed rotational profiles. Comparing with recent observations of large frequency shifts in MXB 1658-298 and 4U 1916-053, we find that the spin-down expected if the atmosphere rotates rigidly is a factor of two to three less than the observed values. If differential rotation is allowed to persist, we find that the upper layers of the atmosphere spin down by an amount comparable to the observed values; however, there is no compelling reason to expect the observed spin frequency to be that of only the outermost layers. We conclude that hydrostatic expansion and angular momentum conservation alone cannot account for the largest frequency shifts observed during Type I bursts.Comment: Submitted to the Astrophysical Journal (13 pages, including 4 figures

Exact Solution for the Metric and the Motion of Two Bodies in (1+1) Dimensional Gravity

We present the exact solution of two-body motion in (1+1) dimensional dilaton gravity by solving the constraint equations in the canonical formalism. The determining equation of the Hamiltonian is derived in a transcendental form and the Hamiltonian is expressed for the system of two identical particles in terms of the Lambert $W$ function. The $W$ function has two real branches which join smoothly onto each other and the Hamiltonian on the principal branch reduces to the Newtonian limit for small coupling constant. On the other branch the Hamiltonian yields a new set of motions which can not be understood as relativistically correcting the Newtonian motion. The explicit trajectory in the phase space $(r, p)$ is illustrated for various values of the energy. The analysis is extended to the case of unequal masses. The full expression of metric tensor is given and the consistency between the solution of the metric and the equations of motion is rigorously proved.Comment: 34 pages, LaTeX, 16 figure

New Types of Thermodynamics from (1+1)(1+1)-Dimensional Black Holes

For normal thermodynamic systems superadditivity $\S$, homogeneity \H and concavity \C of the entropy hold, whereas for $(3+1)$-dimensional black holes the latter two properties are violated. We show that $(1+1)$-dimensional black holes exhibit qualitatively new types of thermodynamic behaviour, discussed here for the first time, in which \C always holds, \H is always violated and $\S$ may or may not be violated, depending of the magnitude of the black hole mass. Hence it is now seen that neither superadditivity nor concavity encapsulate the meaning of the second law in all situations.Comment: WATPHYS-TH93/05, Latex, 10 pgs. 1 figure (available on request), to appear in Class. Quant. Gra

Low frequency of HER2 amplification and overexpression in early onset gastric cancer

BACKGROUND: The recent ToGA trial results indicated that trastuzumab is a new, effective, and well-tolerated treatment for HER2-positive gastric cancer (GC). Although GC mainly affects older patients, fewer than 10% of GC patients are considered early-onset (EOGC) (presenting at the age of 45 years or younger). These EOGC show different clinicopathological and molecular profiles compared to late onset GC suggesting that they represent a separate entity within gastric carcinogenesis. In light of potential trastuzumab benefit, subpopulations of GC such as EOGC (versus late onset) should be evaluated for their frequency of amplification and overexpression using currently available techniques. METHODS: Tissue microarray (TMA) blocks of 108 early onset GC and 91 late onset GC were stained by immunohistochemistry (IHC, Hercep test, DAKO) and chromogenic in situ hybridization (CISH, SPoT-Light, Invitrogen). RESULTS: Overall, we found only 5% HER2 high level amplification and 3% HER2 3+ overexpression (6/199). In addition, 8 patients (4%) showed a low level CISH amplification and 9 patients (4.5%) showed a 2+ IHC score. IHC and CISH showed 92% concordance and CISH showed less heterogeneity than IHC. In 2/199 cases (1%), IHC showed clinically relevant heterogeneity between TMA cores, but all cases with focal IHC 3+ expression were uniformly CISH high level amplified. Early onset GCs showed a significantly lower frequency of HER2 amplification (2%) and overexpression (0%) than late onset GCs (8% and 7% respectively) (p = 0.085 and p = 0.008 respectively). Proximal GC had more HER2 amplification (9% versus 3%) and overexpression (7% versus 2%) than distal tumours although this difference was not significant (p = 0.181 and p = 0.182 respectively). HER2 CISH showed more high level amplification in the intestinal type (7%, 16% if low-level included) compared to the mixed (5%, 5% if low-level included) and diffuse type (3%, 4% if low-level included) GCs (p = 0.029). A similar association was seen for HER2 IHC and histologic type (p = 0.008). Logistic regression indicated a significant association between HER2 expression and age, which remained significant when adjusted for both location and histological type. CONCLUSIONS: Even focal HER2 overexpression in GC points to uniform HER2 amplification by CISH. We show for the first time that early onset GC has a lower frequency of HER2 amplification and overexpression than late onset GC, and confirm that intestinal type GC shows the highest rate of HER2 amplification and overexpression

Exact Black Hole and Cosmological Solutions in a Two-Dimensional Dilaton-Spectator Theory of Gravity

Exact black hole and cosmological solutions are obtained for a special two-dimensional dilaton-spectator ($\phi-\psi$) theory of gravity. We show how in this context any desired spacetime behaviour can be determined by an appropriate choice of a dilaton potential function $V(\phi)$ and a ``coupling function'' $l(\phi)$ in the action. We illustrate several black hole solutions as examples. In particular, asymptotically flat double- and multiple- horizon black hole solutions are obtained. One solution bears an interesting resemblance to the $2D$ string-theoretic black hole and contains the same thermodynamic properties; another resembles the $4D$ Reissner-Nordstrom solution. We find two characteristic features of all the black hole solutions. First the coupling constants in $l(\phi)$ must be set equal to constants of integration (typically the mass). Second, the spectator field $\psi$ and its derivative $\psi^{'}$ both diverge at any event horizon. A test particle with ``spectator charge" ({\it i.e.} one coupled either to $\psi$ or $\psi^{'}$), will therefore encounter an infinite tidal force at the horizon or an ``infinite potential barrier'' located outside the horizon respectively. We also compute the Hawking temperature and entropy for our solutions. In $2D$ $FRW$ cosmology, two non-singular solutions which resemble two exact solutions in $4D$ string-motivated cosmology are obtained. In addition, we construct a singular model which describes the $4D$ standard non-inflationary big bang cosmology ($big-bang\rightarrow radiation\rightarrow dust$). Motivated by the similaritiesbetween $2D$ and $4D$ gravitational field equations in $FRW$ cosmology, we briefly discuss a special $4D$ dilaton-spectator action constructed from the bosonic part of the low energy heterotic string action andComment: 34 pgs. Plain Tex, revised version contains some clarifying comments concerning the relationship between the constants of integration and the coupling constants

Cosmological Models in Two Spacetime Dimensions

Various physical properties of cosmological models in (1+1) dimensions are investigated. We demonstrate how a hot big bang and a hot big crunch can arise in some models. In particular, we examine why particle horizons do not occur in matter and radiation models. We also discuss under what circumstances exponential inflation and matter/radiation decoupling can happen. Finally, without assuming any particular equation of state, we show that physical singularities can occur in both untilted and tilted universe models if certain assumptions are satisfied, similar to the (3+1)-dimensional cases.Comment: 22 pgs., 2 figs. (available on request) (revised version contains `paper.tex' macro file which was omitted in earlier version

Fermions Tunnelling from Black Holes

We investigate the tunnelling of spin 1/2 particles through event horizons. We first apply the tunnelling method to Rindler spacetime and obtain the Unruh temperature. We then apply fermion tunnelling to a general non-rotating black hole metric and show that the Hawking temperature is recovered.Comment: 22 pages, v2: added references, v3: fixed minor typos, v4: added a new section applying fermion tunnelling method to Kruskal-Szekers coordinates, fixed minor typo, and added references, v5: modified introduction and conclusion, fixed typo

Pretransplantation MRD in Older Patients With AML After Treatment With Decitabine or Conventional Chemotherapy

The predictive value of measurable residual disease (MRD) for survival in acute myeloid leukemia (AML) has been firmly established in younger patients treated with intensive chemotherapy. The value of MRD after treatment with decitabine in older patients is unknown. This retrospective analysis included patients ≥60 years of age with AML who received an allogeneic hematopoietic cell transplantation (alloHCT) after treatment with decitabine or intensive chemotherapy. Of the 133 consecutively transplanted patients, 109 had available pretransplantation MRD analyses (by flowcytometry [threshold 0.1%]). Forty patients received decitabine treatment (10-day schedule), and 69 patients received intensive chemotherapy (7 + 3 regimen). Patients who received decitabine were older (median 67 versus 64 years) and more often had MRD (70% versus 38%). OS after alloHCT was comparable in both groups. In the chemotherapy group, MRD-positive patients had a significantly higher relapse probability (subdistribution hazard ratio [sHR] 4.81; P= .0031) and risk of death (HR 2.8; P= .02) compared to MRD-negative patients. In the decitabine group there was no significant association between the presence of MRD and relapse (sHR 0.85; P= .83) or death (HR 0.72; P= .60). Pretransplantation MRD in patients receiving decitabine treatment does not have similar predictive value for relapse or survival in older AML patients receiving an alloHCT, compared to patients receiving intensive chemotherapy