Dominant Role of PI3K p110α over p110β in Insulin and β-Adrenergic Receptor Signalling

Attribution of specific roles to the two ubiquitously expressed PI 3-kinase (PI3K) isoforms p110α and p110β in biological functions they have been implicated, such as in insulin signalling, has been challenging. While p110α has been demonstrated to be the principal isoform activated downstream of the insulin receptor, several studies have provided evidence for a role of p110β. Here we have used isoform-selective inhibitors to estimate the relative contribution of each of these isoforms in insulin signalling in adipocytes, which are a cell type with essential roles in regulation of metabolism at the systemic level. Consistent with previous genetic and pharmacological studies, we found that p110α is the principal isoform activated downstream of the insulin receptor under physiological conditions. p110α interaction with Ras enhanced the strength of p110α activation by insulin. However, this interaction did not account for the selectivity for p110α over p110β in insulin signalling. We also demonstrate that p110α is the principal isoform activated downstream of the β-adrenergic receptor (β-AR), another important signalling pathway in metabolic regulation, through a mechanism involving activation of the cAMP effector molecule EPAC1. This study offers further insights in the role of PI3K isoforms in the regulation of energy metabolism with implications for the therapeutic application of selective inhibitors of these isoforms

Embodied myopia and purchasing behaviour

In conventional thinking, the mind controls the body. Our brains decide something and the body follows suit. However, in many ways this turns out not to be the case. Indeed, our research has found that even simple postures and gestures may be enough to influence our purchasing behaviour

The Radon Monitoring System in Daya Bay Reactor Neutrino Experiment

We developed a highly sensitive, reliable and portable automatic system (H$^{3}$) to monitor the radon concentration of the underground experimental halls of the Daya Bay Reactor Neutrino Experiment. H$^{3}$ is able to measure radon concentration with a statistical error less than 10\% in a 1-hour measurement of dehumidified air (R.H. 5\% at 25$^{\circ}$C) with radon concentration as low as 50 Bq/m$^{3}$. This is achieved by using a large radon progeny collection chamber, semiconductor $\alpha$-particle detector with high energy resolution, improved electronics and software. The integrated radon monitoring system is highly customizable to operate in different run modes at scheduled times and can be controlled remotely to sample radon in ambient air or in water from the water pools where the antineutrino detectors are being housed. The radon monitoring system has been running in the three experimental halls of the Daya Bay Reactor Neutrino Experiment since November 2013

Gold substrate-induced single-mode lasing of GaN nanowires

We demonstrate a method for mode-selection by coupling a GaN nanowire laser to an underlying gold substrate. Multimode lasing of GaN nanowires is converted to single-mode behavior following placement onto a gold film. A mode-dependent loss is generated by the absorbing substrate to suppress multiple transverse-mode operation with a concomitant increase in lasing threshold of only ∼13%. This method provides greater flexibility in realizing practical single-mode nanowire lasers and offers insight into the design of metal-contacted nanoscale optoelectronics

Kaluza-Klein towers for real vector fields in flat space

We consider a free real vector field propagating in a five dimensional flat space with its fifth dimension compactified either on a strip or on a circle and perform a Kalaza Klein reduction which breaks SO(4,1) invariance while reserving SO(3,1) invariance. Taking into account the Lorenz gauge condition, we obtain from the most general hermiticity conditions for the relevant operators all the allowed boundary conditions which have to be imposed on the fields in the extra-dimension. The physical Kaluza-Klein mass towers, which result in a four-dimensional brane, are determined in the different distinct allowed cases. They depend on the bulk mass, on the parameters of the boundary conditions and on the extra parameter present in the Lagrangian. In general, they involve vector states together with accompanying scalar states.Comment: 28 pages, 4 independent table

The S-wave \Lambda\pi phase shift is not large

We study the strong interaction S-wave \Lambda\pi phase shift in the region of the \Xi mass in the framework of a relativistic chiral unitary approach based on coupled channels. All parameters have been previously determined in a fit to strangeness S= -1 S-wave kaon-nucleon data. We find 0^\circ \le \delta_0 \le 1.1^\circ in agreement with previous chiral perturbation theory calculations (or extensions thereof). We also discuss why a recent coupled channel K-matrix calculation gives a result for \delta_0 that is negative and much bigger in magnitude. We argue why that value should not be trusted.Comment: 3 pages, REVTe

White Paper: Measuring the Neutrino Mass Hierarchy

This white paper is a condensation of a report by a committee appointed jointly by the Nuclear Science and Physics Divisions at Lawrence Berkeley National Laboratory (LBNL). The goal of this study was to identify the most promising technique(s) for resolving the neutrino mass hierarchy. For the most part, we have relied on calculations and simulations presented by the proponents of the various experiments. We have included evaluations of the opportunities and challenges for these experiments based on what is available already in the literature.Comment: White paper prepared for Snowmass-201

LArPix: Demonstration of low-power 3D pixelated charge readout for liquid argon time projection chambers

We report the demonstration of a low-power pixelated readout system designed for three-dimensional ionization charge detection and digital readout of liquid argon time projection chambers (LArTPCs). Unambiguous 3D charge readout was achieved using a custom-designed system-on-a-chip ASIC (LArPix) to uniquely instrument each pad in a pixelated array of charge-collection pads. The LArPix ASIC, manufactured in 180 nm bulk CMOS, provides 32 channels of charge-sensitive amplification with self-triggered digitization and multiplexed readout at temperatures from 80 K to 300 K. Using an 832-channel LArPix-based readout system with 3 mm spacing between pads, we demonstrated low-noise ($<$500 e$^-$ RMS equivalent noise charge) and very low-power ($<$100 $\mu$W/channel) ionization signal detection and readout. The readout was used to successfully measure the three-dimensional ionization distributions of cosmic rays passing through a LArTPC, free from the ambiguities of existing projective techniques. The system design relies on standard printed circuit board manufacturing techniques, enabling scalable and low-cost production of large-area readout systems using common commercial facilities. This demonstration overcomes a critical technical obstacle for operation of LArTPCs in high-occupancy environments, such as the near detector site of the Deep Underground Neutrino Experiment (DUNE).Comment: 19 pages, 10 figures, 1 ancillary animation. V3 includes minor revisions based on referee comment