Producao de ovos de vermes gastrintestinais em vacas Nelore, durante o periodo periparto.

bitstream/item/138554/1/COT-27.pdfCNPGC

Avaliação preliminar de parâmetros epidemiológicos da tristeza parasitaria bovina no Mato Grosso do Sul.

Epidemiologia; Bovino; Tristeza parasitaria; Praga; Sanidade; America do Sul; Brasil; Mato Grosso do Sul.bitstream/item/137587/1/PESQ-EM-ANDAMENTO-38.pdfCNPGC

Identificação das espécies e a resistência de parasitos gastrintestinais de ovinos a anti-helmínticos em Mato Grosso do Sul.

bitstream/item/139529/1/COT-108.pd

Produção de ovos de nematódeos gastrintestinais em vacas nelore, durante o período periparto.

Foi avaliada a influencia das epocas de pre e pos-parto sobre a contagem de ovos de mematodeos nas fezes de bovinos de corte. Utilizaram-se 32 vacas Nelore prenhes, sendo 8 de primeira, 12 de segunda e 12 de terceira cria, com o parto previstao para o mes de outubro. Para determinacao do numero de ovoso por grama de fezes (OPG) e coproculturas, foi feita uma coleta de fezes antes do parto (aproximadamente quinze dias antes), uma por ocasiao do parto e seis coletas semanais apos o parto. Nao houve interacao significativa entre o numero de crias das vacas com os valores de OPG nas diferentes coletas. Nao foi observada diferenca significativa, nos valores de OPG, antes e depois do parto, apesar de ter havido uma tendencia de aumento no dia do parto, e nas duassemanas apos o parto. As vacas de primeira cria apresentaram media de OPG maiores do que as vacas de segunda e terceira crias, tanto antes como depois do parto (P<0,05). A Cooperia foi o nematodeo que mais contribuiu para o aumento de OPG. Levando-se em consideracoes o aumento de OPG das vacas e estudos epidemiologicos anteriores, e recomendada a dosificacao das vacas no mes de julho ou agosto.Título em inglês: The production of eggs by gastrointestinal nematodes in Nellore cows, during the peri-parturient period

Epidemiologia dos nematódeos gastrintestinais em bovinos de corte nos cerrados e o controle estratégico no Brasil.

Prevalência das espécies. OPG e imunidade adquirida. Larvas na pastagem. Hipobiose. Mortalidade de animais. Integração entre os helmintos do abomaso. Anorexia. Faixa etária, prejuízos e controle. Custo/Benefício.bitstream/item/104809/1/Epidemiologia-dos-nematoideos-gastrintestinais.pd

Observation of mesoscopic crystalline structures in a two-dimensional Rydberg gas

The ability to control and tune interactions in ultracold atomic gases has paved the way towards the realization of new phases of matter. Whereas experiments have so far achieved a high degree of control over short-ranged interactions, the realization of long-range interactions would open up a whole new realm of many-body physics and has become a central focus of research. Rydberg atoms are very well-suited to achieve this goal, as the van der Waals forces between them are many orders of magnitude larger than for ground state atoms. Consequently, the mere laser excitation of ultracold gases can cause strongly correlated many-body states to emerge directly when atoms are transferred to Rydberg states. A key example are quantum crystals, composed of coherent superpositions of different spatially ordered configurations of collective excitations. Here we report on the direct measurement of strong correlations in a laser excited two-dimensional atomic Mott insulator using high-resolution, in-situ Rydberg atom imaging. The observations reveal the emergence of spatially ordered excitation patterns in the high-density components of the prepared many-body state. They have random orientation, but well defined geometry, forming mesoscopic crystals of collective excitations delocalised throughout the gas. Our experiment demonstrates the potential of Rydberg gases to realise exotic phases of matter, thereby laying the basis for quantum simulations of long-range interacting quantum magnets.Comment: 10 pages, 7 figure

COVID-19 Vaccines and the Virus: Impact on Drug Metabolism and Pharmacokinetics

This article reports on an American Society of Pharmacology and Therapeutics, Division of Drug Metabolism and Disposition symposium held at Experimental Biology on April 2nd, 2022, in Philadelphia. As of July 2022, over 500 million people have been infected with SARS-CoV-2 (the virus causing COVID-19) and over 12,000,000,000 vaccine doses have been administered. Clinically significant interactions between viral infections and hepatic drug metabolism were first recognized over 40 years ago during a cluster of pediatric theophylline toxicity cases attributed to reduced hepatic drug metabolism amidst an influenza B outbreak. Today, a substantive body of research supports that the activated innate immune response generally decreases hepatic cytochrome P450 (CYP) activity. The interactions extend to drug transporters and other organs and have the potential to impact drug absorption, distribution, metabolism, and excretion (ADME). Based on this knowledge, altered ADME is predicted with SARS-CoV-2 infection or vaccination. The report begins with a clinical case exploring the possibility of SARS-CoV-2 vaccination increasing clozapine levels. This is followed by discussions of how SARS-CoV-2 infection or vaccines alter the metabolism and disposition of complex drugs, such as nanoparticles and biologics and small molecule therapies. The review concludes with a discussion of the effects of viral infections on placental amino acid transport and their potential to impact fetal development. The session improved our understanding of the impact of emerging viral infections and vaccine technologies on drug metabolism and disposition, which will help mitigate drug toxicity and improve drug and vaccine safety and effectiveness. Significance Statement Altered pharmacokinetics of small molecule and complex molecule drugs and fetal brain distribution of amino acids following SARS-CoV-2 infection or immunization are possible. The proposed mechanisms involve decreased liver CYP metabolism of small molecules, enhanced innate immune system metabolism of complex molecules and altered placental and fetal blood-brain barrier amino acid transport, respectively. Future research is needed to understand the effects of these interactions on adverse drug responses, drug and vaccine safety and effectiveness and fetal neurodevelopment