La Familia Es Lo Primero - An Oral History Interview with Violeta Rivas

Undergraduate final project submitted to Professor Thomas A. Castillo of the History Department, College of Arts and Humanities for a course sponsored by the Center for the New America, University of Maryland, College Park. Final project for HIST428N Immigrant Life Stories: An Oral History Practicum (spring 2014).In this oral history interview, Violeta Rivas discusses her experience as an immigrant in the United States. Born in Nicaragua in 1960, Violeta and her husband came to the U.S. in 1984 to escape the Sandinista regime and to build a new life. Thirty years later, they are still here. Although Violeta had originally intended to return to Nicaragua, she and her family stayed, and throughout the course of the interview, she displays an acute awareness of her life in retrospect. Leaving her home was a sacrifice, but she did it for her family; every obstacle she faced and every cultural barrier she had to overcome was for her family. That is the essence of the interview, and throughout the course of this oral history, Violeta guides her listeners through the things that matter the most to her: religion, tradition, and moral values. Violeta’s story is not just one of many Central American immigrant narratives; it is a part of a whole, and without it, the picture is not complete

Development Of An Adaptive Augmented Reality Qualification System For Manual Assembly And Maintenance

The manufacturing industry is facing various challenges today - globalization, fast-moving sales markets, short product life cycles, individualization, mass production and diversity of variants are trends that will continue or even increase in the future. Speed and flexibility in production are thus becoming important success factors for companies. To meet the demands of the market, there is a growing necessity to deploy employees flexibly within the production process. This increases the need for additional qualification of workers. By overlaying reality with virtual cues, Head-mounted displays (HMD) can present information in a situation-specific and location-linked manner. Data glasses also offer a high and convertible degree of support through the possibility of providing different media forms while both hands are available at the same time. Augmented Reality (AR) guidance systems are already available on the market and are suitable as permanent assistance systems, but only to a limited extent for qualification aspects. An industrially applicable qualification software that collects expert knowledge from skilled workers and then makes it available to new or inexperienced employees in an adaptive way that promotes learning is currently not available. This paper therefore presents the development of the software AQUA, which taps internal expertise with low effort and creates training courses that convey learning content to learners without over- or under-challenging them

Rhodium-Complex-Functionalized and Polydopamine-Coated CdSe@CdS Nanorods for Photocatalytic NAD+ Reduction

[Image: see text] We report on a photocatalytic system consisting of CdSe@CdS nanorods coated with a polydopamine (PDA) shell functionalized with molecular rhodium catalysts. The PDA shell was implemented to enhance the photostability of the photosensitizer, to act as a charge-transfer mediator between the nanorods and the catalyst, and to offer multiple options for stable covalent functionalization. This allows for spatial proximity and efficient shuttling of charges between the sensitizer and the reaction center. The activity of the photocatalytic system was demonstrated by light-driven reduction of nicotinamide adenine dinucleotide (NAD(+)) to its reduced form NADH. This work shows that PDA-coated nanostructures present an attractive platform for covalent attachment of reduction and oxidation reaction centers for photocatalytic applications

Activated mammalian target of rapamycin is a potential therapeutic target in gastric cancer

<p>Abstract</p> <p>Background</p> <p>The mammalian target of rapamycin (mTOR) plays a key role in cellular growth and homeostasis. The purpose of our present study is to investigate the expression of activated mTOR (p-mTOR) in gastric cancer patients, their prognostic significance and the inhibition effect of RAD001 on tumor growth and to determine whether targeted inhibition of mTOR could be a potential therapeutic strategy for gastric cancer.</p> <p>Methods</p> <p>The expression of p-mTOR was detected in specimens of 181 gastric cancers who underwent radical resection (R0) by immunohistochemistry. The correlation of p-mTOR expression to clinicopathologic features and survival of gastric cancer was studied. We also determined the inhibition effect of RAD001 on tumor growth using BGC823 and AGS human gastric cancer cell lines.</p> <p>Results</p> <p>Immunostaining for p-mTOR was positive in 93 of 181 (51.4%) gastric cancers, closely correlated with lymph node status and pTNM stage. Patients with p-mTOR positive showed significantly shorter disease-free survival (DFS) and overall survival (OS) rates than those with p-mTOR-negative tumors in univariable analyses, and there was a trend toward a correlation between p-mTOR expression and survival in multivariable analyses. RAD001 markedly inhibited dose-dependently proliferation of human gastric carcinoma cells by down-regulating expression of p70s6k, p-p70s6k, C-myc, CyclinD1 and Bcl-2, up-regulating expression of P53.</p> <p>Conclusions</p> <p>In gastric cancer, p-mTOR is a potential therapeutic target and RAD001 was a promising treatment agent with inducing cell cycle arrest and apoptosis by down-regulating expression of C-myc, CyclinD1 and Bcl-2, up-regulating expression of P53.</p