4 research outputs found

    A comparative analysis of the accuracy of different direct impression techniques for multiple implants

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    Background: The aim of this study was to compare the accuracy of different direct implant impression techniques for edentulous arches with multiple implants. Methods: Five experimental groups (n = 5) were assembled. Experimental models were created by a direct splinted technique (EG2 to EG5) and a non-splinted technique (EG1). In EG2 and EG3 synOcta impression copings were splinted with an acrylic resin bar, and in EG4 and EG5 with a light-curing composite resin bar. In EG3 and EG5 the resin bars were sectioned, while the other experimental groups were not. Three-dimensional discrepancies were measured by a computerized coordinate measuring machine. Distortion values among the groups were analysed using one-way repeated measures ANOVA. The post hoc Tukeys test was then performed for multiple comparisons. Results: The highest accuracy was obtained in EG2 (mean deviation: 12.70 mu m). The acrylic bars demonstrated less deviation (12.70 mu m and 22.71 mu m) from the master model than the light-curing composite resin groups and the non-splinted group (41.09 mu m). The post hoc Tukeys test showed no significant difference among the groups when the effect of splint design on accuracy was investigated. Conclusions: For situations where impressions of multiple implants are to be made, splinting impression copings with acrylic resin demonstrate superior results than the non-splinted technique and splinting with light-curing composite

    Effects of genetic variants of CCR5 chemokine receptors on oral squamous cell carcinoma

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    We aimed to evaluate the effect of genetic variants of the chemokine C-C motif receptor (CCR5) in the pathogenesis of oral squamous cell carcinoma (OSCC). A total of 127 patients diagnosed with OSCC and 104 healthy individuals were included in the study. The polymorphisms CCR5 59029 and CCR5-delta32 were assessed with the polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) method from peripheral blood samples of both groups. There was a statistically significant difference between the control and patient groups for CCR5 59029 A/G genotypes (P 0.05). CCR5 59029 GG and CCR5-delta32 DD + ID genotype frequencies were significantly increased in Grade II-III OSCC patients compared with Grade I-II OSCC patients. In conclusion, these results suggested that the G allele of the CCR5 59029 polymorphism might be a risk factor due to the loss of receptor function that might cause increased inflammation leading to the development of OSCC

    Effects of genetic variants of CCR5 chemokine receptors on oral squamous cell carcinoma

    No full text
    ABSTRACT. We aimed to evaluate the effect of genetic variants of the chemokine C-C motif receptor (CCR5) in the pathogenesis of oral squamous cell carcinoma (OSCC). A total of 127 patients diagnosed with OSCC and 104 healthy individuals were included in the study. The polymorphisms CCR5 59029 and CCR5-delta32 were assessed with the polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) method from peripheral blood samples of both groups. There was a statistically significant difference between the control and patient groups for CCR5 59029 A/G genotypes (P < 0.01). Individuals carrying the CCR5 59029 G allele (GG +AG genotypes) had a 2.84-fold increased risk for OSCC (P < 0.0001), and the CCR5 59029 AA genotype frequency was higher in the control group than in the patient group (P < 0.0001). The CCR5-delta 32 genotype frequencies did not differ significantly between controls and cases (P > 0.05). CCR5 59029 GG and CCR5- CCR5 gene in oral carcinoma delta32 DD + ID genotype frequencies were significantly increased in Grade II-III OSCC patients compared with Grade I-II OSCC patients. In conclusion, these results suggested that the G allele of the CCR5 59029 polymorphism might be a risk factor due to the loss of receptor function that might cause increased inflammation leading to the development of OSCC
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