Stability analysis of agegraphic dark energy in Brans-Dicke cosmology

Stability analysis of agegraphic dark energy in Brans-Dicke theory is presented in this paper. We constrain the model parameters with the observational data and thus the results become broadly consistent with those expected from experiment. Stability analysis of the model without best fitting shows that universe may begin from an unstable state passing a saddle point and finally become stable in future. However, with the best fitted model, There is no saddle intermediate state. The agegraphic dark energy in the model by itself exhibits a phantom behavior. However, contribution of cold dark matter on the effective energy density modifies the state of teh universe from phantom phase to quintessence one. The statefinder diagnosis also indicates that the universe leaves an unstable state in the past, passes the LCDM state and finally approaches the sable state in future.Comment: 15 pages, 12 figure

Leucine-rich amelogenin peptide (LRAP) as a surface primer for biomimetic remineralization of superficial enamel defects: An in vitro study

This study was carried out to obtain more information about the assembly of hydroxyapatite bundles formed in the presence of Leucine-Rich Amelogenin Peptide (LRAP) and to evaluate its effect on the remineralization of enamel defects through a biomimetic approach. One or 2 mg/mL LRAP solutions containing 2.5 mM of Ca+2 and 1.5 mM phosphate were prepared (pH = 7.2) and stored at 37 °C for 24 h. The products of the reaction were studied using atomic force microscopy (AFM), transmission electron microscopy (TEM), and selected area electron diffraction (SAED). Vickers surface microhardness recovery (SMR) of acid-etched bovine enamel, with or without LRAP surface treatment, were calculated to evaluate the influence of peptide on the lesion remineralization. Distilled water and 1 or 2 mg/mL LRAP solution (pH = 7.2) were applied on the lesions and the specimens were incubated in mineralization solution (2.5mM Ca+2, 1.5mM PO4 -3, pH = 7.2) for 24 h. One-way ANOVA and Tukey's multi-comparison tests were used for statistical analysis. The pattern of enamel surface repair was studied using FE-SEM. AFM showed the formation of highly organized hierarchical structures, composed of hydroxyapatite (HA) crystals, similar to the dental enamel microstructure. ANOVA procedure showed significant effect of peptide treatment on the calculated SMR (p < 0.001). Tukey's test revealed that peptide treated groups had significantly higher values of SMR. In conclusion, LRAP is able to regulate the formation of HA and enhances the remineralization of acid-etched enamel as a surface treatment agent. © 2015 Wiley Periodicals, Inc

CFD-Calculation of Fluid Flow in a Pressurized Water Reactor

Abstract An accurate description of the fluid flow and heat transfer within a Pressurized Water Reactor (PWR), for the safety analysis and reactor performance is always desirable. In this paper a mathematical model of the fundamental physical phenomena which are associated to a typical PWR is presented. The mathematical model governs the fluid dynamics in the reactor. Using commercial software CFX, a computational fluid dynamics (CFD) code, a three-dimensional flow distribution in the downcomer and the lower plenum of the reactor was also calculated and a valuable analysis of the reactor performance is given. Due to computational limits, simplifications of the core, downcomer and the lower plenum of the reactor are introduced. Nevertheless, it has been shown that computational fluid dynamics and in particular appropriate usage of CFX software improves our understanding of fluid flow distribution, velocity distribution and heat transfer in different parts of the reactor pressure vessel, in particular, in the downcomer and the lower plenum

Preparation of immunotoxin herceptin-botulinum and killing effects on two breast cancer cell lines

Background: Worldwide, breast cancer is the most common cancer diagnosed among women and a leading cause of cancer deaths. The age of onset in Iran has become reduced by a decade for unknown reasons. Herceptin, a humanized monoclonal antibody, is a target therapy for breast cancer cells with over expression of HER2-neu receptors, but it is an expensive drug with only 20 beneficial rate of survival. This study introduces a novel approach to enhance the efficacy of this drug through immunoconjugation of the antibody to botulinum toxin. Decreasing the cost and adverse effects of the antibody were secondary goals of this study. Materials and Methods: Botulinum toxin was conjugated with Herceptin using heterobifunctional cross linkers, succinimidyl acetylthiopropionate (SATP) and sulfo-succinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate (SMCC) according to the supplier's guidelines and tested on two breast cancer cell lines: SK-BR-3 and BT-474. Toxin and Herceptin were also used separately as controls. The cytotoxicity assay was also performed using the new bioconjugate on cultured cells with Alamar blue and a fluorescence plate reader. Results: Herceptin-Toxin bioconjugation significantly improved Herceptin efficacy on both breast cancer cell lines when compared to the control group. Conclusions: Toxin-Herceptin bioconjugation can be a potential candidate with increased efficiency for treating breast cancer patients with over expression of the HER2 receptor

Dynamics of the self-interacting chameleon cosmology

In this article we study the properties of the flat FRW chameleon cosmology in which the cosmic expansion of the Universe is affected by the chameleon field and dark energy. In particular, we perform a detailed examination of the model in the light of numerical analysis. The results illustrate that the interacting chameleon filed plays an important role in late time universe acceleration and phantom crossing.Comment: 13 pages, 8 figures, to appear in Astrophysics and Space Sc

Interacting Holographic dark energy in chameleon tachyon cosmology

We propose in this paper an interacting holographic dark energy (IHDE) model in chameleon--tachyon cosmology by interaction between the components of the dark sectors. In the formalism, the interaction term emerges from the scalar field coupling matter lagrangian in the model rather than being inserted into the formalism as an external source for the interaction. The correspondence between the tachyon field and the holographic dark energy (HDE) densities allows to reconstruct the tachyon scalar field and its potential in a flat FRW universe. The model can show the accelerated expansion of the universe and satisfies the observational data.Comment: 12 pages, 12 figures; will be published in Astrophys. Space Sc

G\"odel-type universes in f(T) gravity

The issue of causality in $f(T)$ gravity is investigated by examining the possibility of existence of the closed timelike curves in the G\"{o}del-type metric. By assuming a perfect fluid as the matter source, we find that the fluid must have an equation of state parameter greater than minus one in order to allow the G\"{o}del solutions to exist, and furthermore the critical radius $r_c$, beyond which the causality is broken down, is finite and it depends on both matter and gravity. Remarkably, for certain $f(T)$ models, the perfect fluid that allows the G\"{o}del-type solutions can even be normal matter, such as pressureless matter or radiation. However, if the matter source is a special scalar field rather than a perfect fluid, then $r_c\rightarrow\infty$ and the causality violation is thus avoided.Comment: 18 pages, introduction revised, reference adde

Cosmological observations in non-local F(R)F(R) cosmology

In this article in a generalization of our previous work, we investigate the dynamics of the non-local $F(R)$ gravity after casting it into local form. The non-singular bouncing behavior and quintom model of dark energy are achieved without involving negative kinetic energy fields. Two cosmological tests are performed to constrain the model parameters. In case of phantom crossing the distance modulus predicted by the model best-fits the observational data. In comparison with the CPL parametrization for drift velocity, the model in some redshift intervals is in good agreement with the data.Comment: 12 pages, 7 figures, will be published in Astrophysics and space scienc

Higher Dimensional Cosmology with Some Dark Energy Models in Emergent, Logamediate and Intermediate Scenarios of the Universe

We have considered N-dimensional Einstein field equations in which four-dimensional space-time is described by a FRW metric and that of extra dimensions by an Euclidean metric. We have chosen the exponential forms of scale factors a and d numbers of b in such a way that there is no singularity for evolution of the higher dimensional Universe. We have supposed that the Universe is filled with K-essence, Tachyonic, Normal Scalar Field and DBI-essence. Here we have found the nature of potential of different scalar field and graphically analyzed the potentials and the fields for three scenario namely Emergent Scenario, Logamediate Scenario and Intermediate Scenario. Also graphically we have depicted the geometrical parameters named statefinder parameters and slow-roll parameters in the higher dimensional cosmology with the above mentioned scenarios.Comment: 21 pages, 36 figure

Chameleonic Generalized Brans--Dicke model and late-time acceleration

In this paper we consider Chameleonic Generalized Brans--Dicke Cosmology in the framework of FRW universes. The bouncing solution and phantom crossing is investigated for the model. Two independent cosmological tests: Cosmological Redshift Drift (CRD) and distance modulus are applied to test the model with the observation.Comment: 20 pages, 15 figures, to be published in Astrophys. Space Sci. (2011