Environmental and Parental Influences on Offspring Health and Growth in Great Tits (Parus major)

PMCID: PMC3728352This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Study of Melamine-Formaldehyde/Phase Change Material Microcapsules for the Preparation of Polymer Films by Extrusion

n-Eicosane-melamine formaldehyde microcapsules of an average size of 1.1 µm and latent heat of fusion of 146.2 ± 5.3 J/g have been prepared. They have been characterized by scanning electron microscopy, FTIR spectroscopy, calorimetric techniques, and thermogravimetric analyses. Under processing conditions, the microcapsules apparently preserved their properties, also maintaining their n-eicosane loading and heat storage capacity under washing conditions (water with detergent at 60¿C). The microcapsules synthesis has been scaled up for the fabrication of functional films by extrusion. For that, polymer films containing 10 wt.% of microcapsules were prepared at a pilot plant level. In those films, even though a fraction of the n-eicosane loading was lost during the extrusion process, the microcapsules showed good compatibility within the polyamide. The percentage of PCM in the polyamide 6 films was estimated by TGA, verifying also the heat storage capacity predicted by DSC (2.6 ± 0.7 J/g). © 2022 by the authors. Licensee MDPI, Basel, Switzerland

The Achilles Heel of the Trojan Horse Model of HIV-1 trans-Infection

To ensure their survival, microbial pathogens have evolved diverse strategies to subvert host immune defenses. The human retrovirus HIV-1 has been proposed to hijack the natural endocytic function of dendritic cells (DCs) to infect interacting CD4 T cells in a process termed trans-infection. Although DCs can be directly infected by certain strains of HIV-1, productive infection of DCs is not required during trans-infection; instead, DCs capture and internalize infectious HIV-1 virions in vesicles for later transmission to CD4 T cells via vesicular exocytosis across the infectious synapse. This model of sequential endocytosis and exocytosis of intact HIV-1 virions has been dubbed the “Trojan horse” model of HIV-1 trans-infection. While this model gained rapid favor as a strong example of how a pathogen exploits the natural properties of its cellular host, our recent studies challenge this model by showing that the vast majority of virions transmitted in trans originate from the plasma membrane rather than from intracellular vesicles. This review traces the experimental lines of evidence that have contributed to what we view as the “rise and decline” of the Trojan horse model of HIV-1 trans-infection

Crk and CrkL adaptor proteins: networks for physiological and pathological signaling

The Crk adaptor proteins (Crk and CrkL) constitute an integral part of a network of essential signal transduction pathways in humans and other organisms that act as major convergence points in tyrosine kinase signaling. Crk proteins integrate signals from a wide variety of sources, including growth factors, extracellular matrix molecules, bacterial pathogens, and apoptotic cells. Mounting evidence indicates that dysregulation of Crk proteins is associated with human diseases, including cancer and susceptibility to pathogen infections. Recent structural work has identified new and unusual insights into the regulation of Crk proteins, providing a rationale for how Crk can sense diverse signals and produce a myriad of biological responses

Prevalence and etiology of community-acquired pneumonia in immunocompromised patients

Background. The correct management of immunocompromised patients with pneumonia is debated. We evaluated the prevalence, risk factors, and characteristics of immunocompromised patients coming from the community with pneumonia. Methods. We conducted a secondary analysis of an international, multicenter study enrolling adult patients coming from the community with pneumonia and hospitalized in 222 hospitals in 54 countries worldwide. Risk factors for immunocompromise included AIDS, aplastic anemia, asplenia, hematological cancer, chemotherapy, neutropenia, biological drug use, lung transplantation, chronic steroid use, and solid tumor. Results. At least 1 risk factor for immunocompromise was recorded in 18% of the 3702 patients enrolled. The prevalences of risk factors significantly differed across continents and countries, with chronic steroid use (45%), hematological cancer (25%), and chemotherapy (22%) the most common. Among immunocompromised patients, community-acquired pneumonia (CAP) pathogens were the most frequently identified, and prevalences did not differ from those in immunocompetent patients. Risk factors for immunocompromise were independently associated with neither Pseudomonas aeruginosa nor non\u2013community-acquired bacteria. Specific risk factors were independently associated with fungal infections (odds ratio for AIDS and hematological cancer, 15.10 and 4.65, respectively; both P = .001), mycobacterial infections (AIDS; P = .006), and viral infections other than influenza (hematological cancer, 5.49; P < .001). Conclusions. Our findings could be considered by clinicians in prescribing empiric antibiotic therapy for CAP in immunocompromised patients. Patients with AIDS and hematological cancer admitted with CAP may have higher prevalences of fungi, mycobacteria, and noninfluenza viruses

Turismo y recreación post COVID-19: Perspectivas, reflexiones y propuestas para una nueva realidad del campo disciplinar

El turismo como campo de estudio está asistiendo a cambios y transformaciones de una magnitud que tal vez no reconozca antecedentes en su devenir histórico. Sobre ese escenario de profundos cambios hizo su aparición la pandemia de COVID-19. El turismo fue una de las primeras actividades en acusar impacto. La Facultad de Turismo de la Universidad Nacional del Comahue reflexiona y aporta conocimiento que permitan avizorar o al menos hipotetizar sobre la nueva normalidad en la que deberemos transitar.Fil: González, Rodrigo C. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Gelós, Mónica B. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Otero, Adriana. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Rodríguez, María Daniela. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Merli, María Carolina. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Suárez, Silvana Reneé. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Merlos, Melisa. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Contreras Moris, Florencia. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Impemba, Marcelo. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Karlau, Alejandro. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Andrés, Juan Manuel. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Mendieta, Martin Diego. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Perini, Maria Magdalena. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Maragliano, María Graciela. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Marenzana, Natalia. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Villaverde, David. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Wojtiuk, Jessica. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Encabo, Matilde. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Mastrocola, Yusara. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Cánepa, Luis. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Barreto, Daniel Paz. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Sánchez, Sandra. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Torre, M. Gabriela. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Hrabar, Melina. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Falquemberg, Cristian. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Rañil, Ana Elizabeth. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Roma Montecino, María Florencia. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Muñoz, Mariela Belén. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Aravena, Melina Solange. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Gutierrez, Noemí Josefina. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Marzari, Carolina. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Gatica, Walter. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Jalil, Mara. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Zanfardini, Marina. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Gutauskas, F. Andrea. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Tamagni, Lucía. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Maluenda, Victoria. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Gazzera, María Alejandra. Universidad Nacional del Comahue. Facultad de Turismo; Argentina.Fil: Lombardo, Lorenna. Universidad Nacional del Comahue. Facultad de Turismo; Argentina