An individual patient data meta-analysis of adjuvant therapy with uracil–tegafur (UFT) in patients with curatively resected rectal cancer

Uracil–Tegafur (UFT), an oral fluorinated pyrimidine chemotherapeutic agent, has been used for adjuvant chemotherapy in curatively resected colorectal cancer patients. Past trials and meta-analyses indicate that it is somewhat effective in extending survival of patients with rectal cancer. The objective of this study was to perform a reappraisal of randomised clinical trials conducted in this field. We designed an individual patient-based meta-analysis of relevant clinical trials to examine the benefit of UFT for curatively resected rectal cancer in terms of overall survival (OS), disease-free survival (DFS), and local relapse-free survival (LRFS). We analysed individual patient data of five adjuvant therapy randomised clinical trials for rectal cancer, which met the predetermined inclusion criteria. These five trials had a combined total of 2091 patients, UFT as adjuvant chemotherapy compared to surgery-alone, 5-year follow-up, intention-to-treat-based analytic strategy, and similar endpoints (OS and DFS). In a pooled analysis, UFT had significant advantage over surgery-alone in terms of both OS (hazard ratio, 0.82; 95% confidence interval (CI), 0.70–0.97; P=0.02) and DFS (hazard ratio, 0.73; 95%CI, 0.63–0.84; P<0.0001). This individual patient-based meta-analysis demonstrated that oral UFT significantly improves both OS and DFS in patients with curatively resected rectal cancer

Prevention of bone loss with risedronate in breast cancer survivors: a randomized, controlled clinical trial

Durante la sesión del grupo de trabajo Difusión y marketing de la profesión y disciplina participaron representantes de cuatro de las Escuelas del país (UADER: Cristina Castello; UNM: Marlene Bar; UNMdP: Alicia Hernández, Gladys Fernández, Valeria Tomaino, Andrés Vuotto y Carlos Schwindt; UNLP: Carla Gutiérrez y Carolina Unzurrunzaga). Para comenzar con el trabajo se planteó que los participantes compartieran las acciones de difusión que emprenden desde sus Escuelas.Facultad de Humanidades y Ciencias de la Educació