388 research outputs found
Isolation of 1-(3',4'-dihydroxyphenyl)-3-(2",4",6"-trihydroxyphenyl)-propan-2-ol from grape seed extract and evaluation of its antioxidant and antispasmodic potential
HPLC profiling of phenolics in grape seed extracts revealed a prominent peak of an unknown substance with concentrations up to 5.3%. Spectroscopic data allowed the identification of the compound 1 as 1-(3′,4′-dihydroxyphenyl)-3-(2″,4″,6″-trihydroxyphenyl)-propan-2-ol. 1 is known to be produced from catechin and epicatechin through anaerobic bacteria from human, as well as the rat, intestines. It was hypothesized that the marc remaining after expression of juice from grapes became infested during storage, resulting in the production of 1. Because compound 1 is infrequently found in nature and has never been found in grape seeds, its presence may be considered a marker of an unwanted anaerobic bacterial process occurring during production. The antioxidant potential of 1 was determined by DPPH, ABTS, and FRAP (ferric reducing antioxidant power) assays and compared to the potential of the following compounds: phloroglucine, pyrogallol, gallic acid, catechin, and epicatechin. Furthermore, it was established that 1 significantly reduced guinea pig ileum contraction induced by histamine
Beam profile investigation of the new collimator system for the J-PET detector
Jagiellonian Positron Emission Tomograph (J-PET) is a multi-purpose detector
which will be used for search for discrete symmetries violations in the decays
of positronium atoms and for investigations with positronium atoms in
life-sciences and medical diagnostics. In this article we present three methods
for determination of the beam profile of collimated annihilation gamma quanta.
Precise monitoring of this profile is essential for time and energy calibration
of the J-PET detector and for the determination of the library of model signals
used in the hit-time and hit-position reconstruction. We have we have shown
that usage of two lead bricks with dimensions of 5x10x20 cm^3 enables to form a
beam of annihilation quanta with Gaussian profile characterized by 1 mm FWHM.
Determination of this characteristic is essential for designing and
construction the collimator system for the 24-module J-PET prototype.
Simulations of the beam profile for different collimator dimensions were
performed. This allowed us to choose optimal collimation system in terms of the
beam profile parameters, dimensions and weight of the collimator taking into
account the design of the 24 module J-PET detector.Comment: 14 pages, 9 figure
A feasibility study of ortho-positronium decays measurement with the J-PET scanner based on plastic scintillators
We present a study of the application of the Jagiellonian Positron Emission
Tomograph (J-PET) for the registration of gamma quanta from decays of
ortho-positronium (o-Ps). The J-PET is the first positron emission tomography
scanner based on organic scintillators in contrast to all current PET scanners
based on inorganic crystals. Monte Carlo simulations show that the J-PET as an
axially symmetric and high acceptance scanner can be used as a multi-purpose
detector well suited to pursue research including e.g. tests of discrete
symmetries in decays of ortho-positronium in addition to the medical imaging.
The gamma quanta originating from o-Ps decay interact in the plastic
scintillators predominantly via the Compton effect, making the direct
measurement of their energy impossible. Nevertheless, it is shown in this paper
that the J-PET scanner will enable studies of the o-Ps decays with
angular and energy resolution equal to and
keV, respectively. An order of magnitude shorter decay
time of signals from plastic scintillators with respect to the inorganic
crystals results not only in better timing properties crucial for the reduction
of physical and instrumental background, but also suppresses significantly the
pileups, thus enabling compensation of the lower efficiency of the plastic
scintillators by performing measurements with higher positron source
activities
Potential of the J-PET detector for studies of discrete symmetries in decays of positronium atom - a purely leptonic system
The Jagiellonian Positron Emission Tomograph (J-PET) was constructed as a
prototype of the cost-effective scanner for the simultaneous metabolic imaging
of the whole human body. Being optimized for the detection of photons from the
electron-positron annihilation with high time- and high angular-resolution, it
constitutes a multi-purpose detector providing new opportunities for studying
the decays of positronium atoms. Positronium is the lightest purely leptonic
object decaying into photons. As an atom bound by a central potential it is a
parity eigenstate, and as an atom built out of an electron and an anti-electron
it is an eigenstate of the charge conjugation operator. Therefore, the
positronium is a unique laboratory to study discrete symmetries whose precision
is limited in principle by the effects due to the weak interactions expected at
the level of (~10) and photon-photon interactions expected at the level
of (~10). The J-PET detector enables to perform tests of discrete
symmetries in the leptonic sector via the determination of the expectation
values of the discrete-symmetries-odd operators, which may be constructed from
the spin of ortho-positronium atom and the momenta and polarization vectors of
photons originating from its annihilation. In this article we present the
potential of the J-PET detector to test the C, CP, T and CPT symmetries in the
decays of positronium atoms.Comment: 27 pages, 6 figure
Searches for discrete symmetries violation in ortho-positronium decay using the J-PET detector
In this paper we present prospects for using the J-PET detector to search for
discrete symmetries violations in a purely leptonic system of the positronium
atom. We discuss tests of CP and CPT symmetries by means of ortho-positronium
decays into three photons. No zero expectation values for chosen correlations
between ortho-positronium spin and momentum vectors of photons would imply the
existence of physics phenomena beyond the Standard Model. Previous measurements
resulted in violation amplitude parameters for CP and CPT symmetries consistent
with zero, with an uncertainty of about 10-3. The J-PET detector allows to
determine those values with better precision thanks to a unique time and
angular esolution combined with a high geometrical acceptance. Achieving the
aforementioned is possible due to application of polymer scintillators instead
of crystals as detectors of annihilation quanta.Comment: in Nukleonika 201
Calculation of time resolution of the J-PET tomograph using the Kernel Density Estimation
In this paper we estimate the time resolution of the J-PET scanner built from
plastic scintillators. We incorporate the method of signal processing using the
Tikhonov regularization framework and the Kernel Density Estimation method. We
obtain simple, closed-form analytical formulas for time resolutions. The
proposed method is validated using signals registered by means of the single
detection unit of the J-PET tomograph built out from 30 cm long plastic
scintillator strip. It is shown that the experimental and theoretical results,
obtained for the J-PET scanner equipped with vacuum tube photomultipliers, are
consistent.Comment: 25 pages, 11 figure
Multichannel FPGA based MVT system for high precision time (20~ps~RMS) and charge measurement
In this article it is presented an FPGA based ulti-oltage hreshold
(MVT) system which allows of sampling fast signals ( ns rising and falling
edge) in both voltage and time domain. It is possible to achieve a precision of
time measurement of ps RMS and reconstruct charge of signals, using a
simple approach, with deviation from real value smaller than 10.
Utilization of the differential inputs of an FPGA chip as comparators together
with an implementation of a TDC inside an FPGA allowed us to achieve a compact
multi-channel system characterized by low power consumption and low production
costs. This paper describes realization and functioning of the system
comprising 192-channel TDC board and a four mezzanine cards which split
incoming signals and discriminate them. The boards have been used to validate a
newly developed Time-of-Flight Positron Emission Tomography system based on
plastic scintillators. The achieved full system time resolution of
(TOF) ps is by factor of two better with respect to the
current TOF-PET systems.Comment: Accepted for publication in JINST, 10 pages, 8 figure
Studies of unicellular micro-organisms Saccharomyces cerevisiae by means of Positron Annihilation Lifetime Spectroscopy
Results of Positron Annihilation Lifetime Spectroscopy (PALS) and microscopic
studies on simple microorganisms: brewing yeasts are presented. Lifetime of
ortho - positronium (o-Ps) were found to change from 2.4 to 2.9 ns (longer
lived component) for lyophilised and aqueous yeasts, respectively. Also
hygroscopicity of yeasts in time was examined, allowing to check how water -
the main component of the cell - affects PALS parameters, thus lifetime of o-Ps
were found to change from 1.2 to 1.4 ns (shorter lived component) for the dried
yeasts. The time sufficient to hydrate the cells was found below 10 hours. In
the presence of liquid water an indication of reorganization of yeast in the
molecular scale was observed.
Microscopic images of the lyophilised, dried and wet yeasts with best
possible resolution were obtained using Inverted Microscopy (IM) and
Environmental Scanning Electron Microscopy (ESEM) methods. As a result visible
changes to the surface of the cell membrane were observed in ESEM images.Comment: Nukleonika (2015
Trilateration-based reconstruction of ortho-positronium decays into three photons with the J-PET detector
This work reports on a new reconstruction algorithm allowing to reconstruct
the decays of ortho-positronium atoms into three photons using the places and
times of photons recorded in the detector. The method is based on trilateration
and allows for a simultaneous reconstruction of both location and time of the
decay. Results of resolution tests of the new reconstruction in the J-PET
detector based on Monte Carlo simulations are presented, which yield a spatial
resolution at the level of 2 cm (FWHM) for X and Y and at the level of 1 cm
(FWHM) for Z available with the present resolution of J-PET after application
of a kinematic fit. Prospects of employment of this method for studying angular
correlations of photons in decays of polarized ortho-positronia for the needs
of tests of CP and CPT discrete symmetries are also discussed. The new
reconstruction method allows for discrimination of background from random
three-photon coincidences as well as for application of a novel method for
determination of the linear polarization of ortho-positronium atoms, which is
also introduced in this work.Comment: 18 pages, 5 figures. Accepted for publication in Nuclear
Instrumentation and Methods in Physics Research
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