24 research outputs found
Zasady postępowania diagnostyczno-terapeutycznego u chorych na nowotwory podścieliskowe przewodu pokarmowego (GIST)
The sarcopenia and physical frailty in older people: multi-component treatment strategies (SPRINTT) project: description and feasibility of a nutrition intervention in community-dwelling older Europeans.
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadBackground: The "Sarcopenia and Physical Frailty in Older People: Multicomponent Treatment Strategies" (SPRINTT) project sponsored a multi-center randomized controlled trial (RCT) with the objective to determine the effect of physical activity and nutrition intervention for prevention of mobility disability in community-dwelling frail older Europeans. We describe here the design and feasibility of the SPRINTT nutrition intervention, including techniques used by nutrition interventionists to identify those at risk of malnutrition and to carry out the nutrition intervention.
Methods: SPRINTT RCT recruited older adults (≥ 70 years) from 11 European countries. Eligible participants (n = 1517) had functional limitations measured with Short Physical Performance Battery (SPPB score 3-9) and low muscle mass as determined by DXA scans, but were able to walk 400 m without assistance within 15 min. Participants were followed up for up to 3 years. The nutrition intervention was carried out mainly by individual nutrition counseling. Nutrition goals included achieving a daily protein intake of 1.0-1.2 g/kg body weight, energy intake of 25-30 kcal/kg of body weight/day, and serum vitamin D concentration ≥ 75 mmol/L. Survey on the method strategies and feasibility of the nutrition intervention was sent to all nutrition interventionists of the 16 SPRINTT study sites.
Results: Nutrition interventionists from all study sites responded to the survey. All responders found that the SPRINTT nutrition intervention was feasible for the target population, and it was well received by the majority. The identification of participants at nutritional risk was accomplished by combining information from interviews, questionnaires, clinical and laboratory data. Although the nutrition intervention was mainly carried out using individual nutritional counselling, other assisting methods were used as appropriate.
Conclusion: The SPRINTT nutrition intervention was feasible and able to adapt flexibly to varying needs of this heterogeneous population. The procedures adopted to identify older adults at risk of malnutrition and to design the appropriate intervention may serve as a model to deliver nutrition intervention for community-dwelling older people with mobility limitations.
Keywords: Energy intake; Nutrition counselling; Nutrition intervention; Protein intake; SPRINTT.University of Helsinki including Helsinki University Central Hospital
Innovative Medicine Initiative (IMI)
Juho Vainio foundatio
Natural and synthetic 5,8-quinolinedione derivatives exhibited biological activity
The compounds produced by a living organisms are most commonly used as
medicinal agents and starting materials to the preparation of new semi-synthetic
derivatives. It is estimated that over 23% of currently used medicinal products are
natural substances. Natural compounds and their semisynthetic derivatives are
most often used in the treatment of cancer and the treatment of infectious diseases.
One of the groups of compounds obtained from Gram-positive bacterium are
5,8-quinolinedione antibiotics, like: streptonigrin, lavendamycin and streptonigron.
The all compounds exhibit high anticancer, antimicrobial and antiviral activity.
Unfortunately due to high toxicity this alkaloids did not find place in the therapy.
The mechanism of action depends on interaction of compounds with the nicotinamide
quinone oxidoreductase 1 (NQO1). The 5,8-quinolinedione can be reduced by
the NAD(P)H as a cofactor to form the semiquinone or hydroquinone intermediates.
These compounds can react with oxygen yielding a regenerated 5,8-quinolinedione
fragment and creating the hydroxyl radicals, which are ultimately responsible
for the DNA strands cleavage.
The structure–activity relationship study has shown that the most important
part of the molecule is the 5,8-quinolinedione moiety. Furthermore, it was found,
that the introduction of amine, hydroxyl or thiol substituents at position 6 or 7 of the
5,8-quinolinedione moiety results in an enhanced biological activity.
A lot of synthetic derivatives of 5,8-quinolinediones which containing amine,
alkoxyl and thiol groups at the C-6 or/and C-7 positions have been obtained during
the last few years. Commonly this compounds are obtained in the reaction of
6,7-dichloro-5,8-quinolinedione with nucleophilic factor. Depending on the reaction
conditions, mono- or di-substituted derivatives are obtained. Most of synthesized
compounds exhibit high biological activity, like: anticancer, antibacterial, antiviral,
anti-inflammatory
Biological activity of acetylene compounds of natural origin
The natural acetylenic products containing at least one a carbon-carbon triple
bond, are important class of compounds widely distributed in the environment.
Development of spectroscopic techniques and methods for the isolation of metabolites
allowed the extraction of natural acetylenic compounds. The most of these substances
have been obtained from marine organisms, such as: cyanobacteria, algae
and sponges. The next source of metabolites are herbal plants, which were used in
the Chinese traditional medicine. A many of them show interesting biological activity.
The first isolated natural compound possessing an acetylenic unit was dehydromatricaria
ester, which was obtained from rhizome European goldenrod (Solidago
virgaurea). To present day have been found and researched more than 2000 natural
acetylenic metabolites.
Due to the chemical structure, natural acetylenic compounds were divided into
six groups: peptides, aromatic compounds, enediyne antibiotics, sterols, carotenoids,
and poliacetylenic compounds .
This article focuses natural acetylenic substances, which exhibit interesting biological
properties, particularly anticancer ones. The review presents many of such
metabolites, including fatty alcohols, ketones, acids, ethers, and carotenoids
The possibilities of dentition reconstruction with the use of bicortical implants : review of literature
Współcześnie implantologia stanowi podstawową metodę
zaopatrzenia protetycznego pacjentów z brakami zębowymi,
umożliwiając zarówno rehabilitację, jak i rekonstrukcję
protetyczną. Implanty cechują się przede wszystkim biozgodnością
oraz rozmaitym zastosowaniem klinicznym (wykorzystanie
zarówno jako filarów pod prace stałe, jak i do wzmocnienia
retencji protez ruchomych). Obok powszechnie stosowanych
implantów śródkostnych bazowanych na systemie Brånemarka
swoje miejsce znalazły również implanty bikortykalne, oparte
o dwie blaszki istoty zbitej, co warunkuje odmienności biomechaniczne
oraz kliniczne pracy z tego typu wszczepami. Mogą
być one stosowane do odbudowy braków zębowych o rozmaitej
etiologii (choroba próchnicowa, periodontopatie, urazy) z bardzo
dobrą skutecznością i stanowią alternatywę dla tradycyjnych
systemów implantologicznych.Nowadays, implantology is the basic metod of prosthetic
supply of patients with dental deficiencies. It enables both
prosthodontic rehabilitation and reconstruction. Implants are
primarly biocompatible and of vast clinical application (both
as pillars for fixed prosthesis and as an additional retention for
mobile ones). Besides the commonly used intraosseus implants
based on Brånemark’s system, bicortical implants were brought
to stomatology. Since they rest on both layers of lamina dura,
their biomechanics as well as clinical approach differs. They can
be used to reconstuct teeth loss of a variety of aetiology (caries,
periodontitis, traumas) with very high efficacy and constitute an
alternatice to traditional implant systems