The outcome of surgical treatment in patients with obstructive colorectal cancer

orectal cancer obstructions are responsible for about 85% of colonic emergencies. The aim of this study was to investigate the results of urgent surgical intervention that applied in acute colonic obstructions related to cancer. Methods: In this study, 86 cases presenting with acute colonic obstruction who were operated with the diagnosis of colonic tumor between January 2010 and December 2010 were assessed retrospectively. Age, gender, symptoms on presentation, presence of concomitant disease, surgical methods applied, complication and mortality rates were recorded.Results: Fifty of the cases were male, 36 were female. The mean age was 63.6 years. Twenty cases had undergone emergency colonoscopic examination at diagnosis and an obstructive lesion had been observed. The surgical operations performed were right hemicolectomy in 18, sigmoid resection in 34, left hemicolectomy in 10, abdomino-perineal resection in 2, subtotal colectomy in 4, transverse colectomy in two. Primary anastomosis was performed in thirty-four cases. Mortality was observed in 12 cases. Conclusions: In selected cases of left colon cancers with obstruction, resection and primary anastomosis is generally possible. Those over 70, presence of co-morbidities, albumin level under 3 g/dl, ASA score 3 and higher, blood loss of more than 500 ml, and preoperative blood transfusion were related to the high postoperative morbidity.Key words: Colorectal cancer, obstruction, surgical treatment, outcome

The effect of mirtazapine on methotrexate-induced toxicity in rat liver

Cetin, Nihal/0000-0003-3233-8009;WOS: 000329767700004Methotrexate is used as a chemotherapeutic agent and its anti-oxidant activity is used to treat many cancer types. This study conducts a biochemical and histopathological investigation into whether mirtazapine has a protective effect on methotrexate-induced hepatotoxicity in rats. Distilled water was given to a healthy group intraperitoneally. Methotrexate alone was injected in the control group, again intraperitoneally. Mirtazapine and, 1 h later, methotrexate were given to the rats in the final group. This procedure was repeated over 7 days. in the control group rats receiving methotrexate, blood AST, ALT, and LDH levels were 227 +/- 3 mu mol/l, 85 +/- 2 mu mol/l, and 357 +/- 13 mu mol/l, respectively. in the rats receiving mirtazapine and methotrexate, these values were 152 +/- 3 mu mol/l, 25 +/- 1 mu mol/l, and 141 +/- 15 mu mol/l. in the healthy rat group, AST, ALT, and LDH levels were 136 mu mol/l, 20 mu mol/l, and 133 mu mol/l, respectively. Histopathologically, apoptotic bodies with condensed cytoplasm, peripheral, and pyknotic nuclei in the hepatocytes, focal necrosis and intense inflammation in the interstitial areas were present in the control group. in the methotrexate and mirtazapine group, there were no apoptotic bodies or inflammation, only isolated necrosis in the hepatocytes. in conclusion, mirtazapine protected the liver against methotrexate toxicity.Scientific Research Project of Ataturk University-BAPAtaturk University [2005/160-2008/126]This study was supported by the Scientific Research Project of Ataturk University-BAP 2005/160-2008/126. We thank Prof. Fatih Akcay for his contributions to this study

The effect of hippophae rhamnoides extract on oxidative damage on rat's gastric tissue depending on Co-implementation of methotrexate and indomethacin

Kurt, Nezahat/0000-0002-1685-5332; Cetin, Nihal/0000-0003-3233-8009WOS: 000337943300014The effect of Hippophae rhamnoides (HR) extract on oxidative damage on rat's gastric tissue depending on co-implementation of methotrexate (MTX) and indomethacin (IND) was investigated biochemically and histopathologically. HR extract was given to HR extract-given (HRIM) group of rats with dose of 50 mg/kg, and to IND+MTX-implemented rat group (IMG) orally with distilled water through catheter. One hour after, IND and MTX combination was given to HRIM and IMG groups orally for 7 days with dose of 5 mg/kg. in gastric tissues of IMG group, the MDA amount increased to healthy-sham (SG) and HRIM groups. the amount of tGSH, in IMG group's gastric tissue decreased to SG and HRIM groups. Serious focal erosions, sub-mucosal edemas and mixed-type inflammatory cell infiltrations have been observed on surface epithelium of histopathological sections of stomachs of IMG group. HR extract prevent the gastric damage in rats' gastric tissues, which was formed by MTX and IND combination