22 research outputs found
Superconducting, Insulating, and Anomalous Metallic Regimes in a Gated Two-Dimensional Semiconductor-Superconductor Array
The superconductor-insulator transition in two dimensions has been widely
investigated as a paradigmatic quantum phase transition. The topic remains
controversial, however, because many experiments exhibit a metallic regime with
saturating low-temperature resistance, at odds with conventional theory. Here,
we explore this transition in a novel, highly controllable system, a
semiconductor heterostructure with epitaxial Al, patterned to form a regular
array of superconducting islands connected by a gateable quantum well. Spanning
nine orders of magnitude in resistance, the system exhibits regimes of
superconducting, metallic, and insulating behavior, along with signatures of
flux commensurability and vortex penetration. An in-plane magnetic field
eliminates the metallic regime, restoring the direct superconductor-insulator
transition, and improves scaling, while strongly altering the scaling exponent
DanMAC5:a browser of aggregated sequence variants from 8,671 whole genome sequenced Danish individuals
Inferring cellular networks – a review
In this review we give an overview of computational and statistical methods to reconstruct cellular networks. Although this area of research is vast and fast developing, we show that most currently used methods can be organized by a few key concepts. The first part of the review deals with conditional independence models including Gaussian graphical models and Bayesian networks. The second part discusses probabilistic and graph-based methods for data from experimental interventions and perturbations
The DANish randomized, double-blind, placebo controlled trial in patients with chronic HEART failure (DANHEART): A 2 × 2 factorial trial of hydralazine-isosorbide dinitrate in patients with chronic heart failure (H-HeFT) and metformin in patients with chronic heart failure and diabetes or prediabetes (Met-HeFT)
Objectives: The DANHEART trial is a multicenter, randomized (1:1), parallel-group, double-blind, placebo-controlled study in chronic heart failure patients with reduced ejection fraction (HFrEF). This investigator driven study will include 1500 HFrEF patients and test in a 2 × 2 factorial design: 1) if hydralazine-isosorbide dinitrate reduces the incidence of death and hospitalization with worsening heart failure vs. placebo (H-HeFT) and 2) if metformin reduces the incidence of death, worsening heart failure, acute myocardial infarction, and stroke vs. placebo in patients with diabetes or prediabetes (Met-HeFT). Methods: Symptomatic, optimally treated HFrEF patients with LVEF ≤40% are randomized to active vs. placebo treatment. Patients can be randomized in either both H-HeFT and Met-HeFT or to only one of these study arms. In this event-driven study, it is anticipated that 1300 patients should be included in H-HeFT and 1100 in Met-HeFT and followed for an average of 4 years. Results: As of May 2020, 296 patients have been randomized at 20 centers in Denmark. Conclusion: The H-HeFT and Met-HeFT studies will yield new knowledge about the potential benefit and safety of 2 commonly prescribed drugs with limited randomized data in patients with HFrEF