99 research outputs found
Measurement-induced macroscopic superposition states in cavity optomechanics
We present a novel proposal for generating quantum superpositions of
macroscopically distinct states of a bulk mechanical oscillator, compatible
with existing optomechanical devices operating in the readily achievable
bad-cavity limit. The scheme is based on a pulsed cavity optomechanical quantum
non-demolition (QND) interaction, driven by displaced non-Gaussian states, and
measurement-induced feedback, avoiding the need for strong single-photon
optomechanical coupling. Furthermore, we show that single-quadrature cooling of
the mechanical oscillator is sufficient for efficient state preparation, and we
outline a three-pulse protocol comprising a sequence of QND interactions for
squeezing-enhanced cooling, state preparation, and tomography.Comment: 7 pages, 5 figure
Backflow in a Fermi Liquid
We calculate the backflow current around a fixed impurity in a Fermi liquid.
The leading contribution at long distances is radial and proportional to 1/r^2.
It is caused by the current induced density modulation first discussed by
Landauer. The familiar 1/r^3 dipolar backflow obtained in linear response by
Pines and Nozieres is only the next to leading term, whose strength is
calculated here to all orders in the scattering. In the charged case the
condition of perfect screening gives rise to a novel sum rule for the phase
shifts. Similar to the behavior in a classical viscous liquid, the friction
force is due only to the leading contribution in the backflow while the dipolar
term does not contribute.Comment: 4 pages, 1 postscript figure, uses ReVTeX and epsfig macro, submitted
to Physical Review Letter
Longitudinal Force on a Moving Potential
We show a formal result of the longitudinal force acting on a moving
potential. The potential can be velocity-dependent, which appears in various
interesting physical systems, such as electrons in the presence of a magnetic
flux-line, or phonons scattering off a moving vortex. By using the phase-shift
analysis, we are able to show the equivalence between the adiabatic
perturbation theory and the kinetic theory for the longitudinal force in the
dilute gas limit.Comment: RevTeX, 4 pages, revised tex
Backflow and dissipation during the quantum decay of a metastable Fermi liquid
The particle current in a metastable Fermi liquid against a first-order phase
transition is calculated at zero temperature. During fluctuations of a droplet
of the stable phase, in accordance with the conservation law, not only does an
unperturbed current arise from the continuity at the boundary, but a backflow
is induced by the density response. Quasiparticles carrying these currents are
scattered by the boundary, yielding a dissipative backflow around the droplet.
An energy of the hydrodynamic mass flow of the liquid and a friction force
exerted on the droplet by the quasiparticles have been obtained in terms of a
potential of their interaction with the droplet.Comment: 5 pages (REVTeX), to be published in Phys. Rev.
Floquet Formalism of Quantum Pumps
We review Floquet formalism of quantum electron pumps. In the Floquet
formalism the quantum pump is regarded as a time dependent scattering system,
which allows us to go beyond the adiabatic limit. It can be shown that the
well-known adiabatic formula given by Brouwer can be derived from the adiabatic
limit of Floquet formalism. We compare various physical properties of the
quantum pump both in the adiabatic and in the non-adiabatic regime using the
Floquet theory.Comment: Latex2e 16 pages, 6 figures. A review paper to appear in Int. J. Mod.
Phys.
Microscopic theory of vortex dynamics in homogeneous superconductors
Vortex dynamics in fermionic superfluids is carefully considered from the
microscopic point of view. Finite temperatures, as well as impurities, are
explicitly incorporated. To enable readers understand the physical
implications, macroscopic demonstrations based on thermodynamics and
fluctuations- dissipation theorems are constructed. For the first time a clear
summary and a critical review of previous results are given.Comment: Presentations are made more straightforward. A detailed presentation
that why the vortex friction is finite when the geometric phase exists, as
required by referees, though I think it is obviou
A glycosylated recombinant human granulocyte colony stimulating factor produced in a novel protein production system (AVI-014) in healthy subjects: a first-in human, single dose, controlled study
BACKGROUND: AVI-014 is an egg white-derived, recombinant, human granulocyte colony-stimulating factor (G-CSF). This healthy volunteer study is the first human investigation of AVI-014. METHODS: 24 male and female subjects received a single subcutaneous injection of AVI-014 at 4 or 8 mcg/kg. 16 control subjects received 4 or 8 mcg/kg of filgrastim (Neupogen, Amgen) in a partially blinded, parallel fashion. RESULTS: The Geometric Mean Ratio (GMR) (90% CI) of 4 mcg/kg AVI-014/filgrastim AUC(0-72 hr) was 1.00 (0.76, 1.31) and Cmax was 0.86 (0.66, 1.13). At the 8 mcg/kg dose, the AUC(0-72) GMR was 0.89 (0.69, 1.14) and Cmax was 0.76 (0.58, 0.98). A priori pharmacokinetic bioequivalence was defined as the 90% CI of the GMR bounded by 0.8-1.25. Both the white blood cell and absolute neutrophil count area under the % increase curve AUC(0-9 days) and Cmax (maximal % increase from baseline)GMR at 4 and 8 mcg/kg fell within the 0.5-2.0 a priori bound set for pharmacodynamic bioequivalence. The CD 34+ % increase curve AUC(0-9 days) and Cmax GMR for both doses was approximately 1, but 90% confidence intervals were large due to inherent variance, and this measure did not meet pharmacodynamic bioequivalence. AVI-014 demonstrated a side effect profile similar to that of filgrastim. CONCLUSION: AVI-014 has safety, pharmacokinetic, and pharmacodynamic properties comparable to filgrastim at an equal dose in healthy volunteers. These findings support further investigation in AVI-014
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