Cleft palate caused by congenital teratoma

International audienceA cleft palate results from incomplete fusion of the lateral palatine processes, the median nasal septum and the median palatine process. This case report describes a rare case of congenital teratoma originating from the nasal septum that may have interfered with the fusion of the palatal shelves during embryonic development, resulting in a cleft palate. An infant girl was born at 40 weeks of gestation weighing 3020 g with a complete cleft palate associated with a large central nasopharyngeal tumour. Computed tomography (CT) of the head showed a well defined mass of mixed density. The tumour was attached to the nasal septum in direct contact with the cleft palate. A biopsy confirmed the teratoma. Tumour resection was performed at 5 months, soft palate reconstruction at 7 months and hard palate closure at 14 months. There was no sign of local recurrence 1 year later. Most teratomas are benign and the prognosis is usually good. However, recurrence is not rare if germ cell carcinomatous foci are present within the teratoma. For these reasons, we advocate the use of a two-stage procedure in which closure of the cleft palate is postponed until histological examination confirms complete excision of the teratoma

Impact of early intravelar veloplasty at six months on mandibular growth in patients with Pierre Robin Sequence

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Management of Large Maxillomandibular Osteofibrous Dysplasia as Part of a Humanitarian Mission

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The contribution of telemedicine to humanitarian surgery

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Maxillary restoration with complete maxillary prosthesis supported by implants with immediate loading: clinical retrospective study of 48 cases

Introduction: In recent years, the immediate loading procedure for the rehabilitation of edentulous jaws has gained popularity among patients and practitioners. The purpose of this study was to evaluate implant and prosthetic success rates for the rehabilitation of edentulous maxillae using tilted distal implants and immediate loading of prostheses, after 2 years. Material and method: Patients included in the study received a complete prosthesis of the upper arch, attached to 4, 5 or 6 implants. The provisional prosthesis was fixed the same day the implants were placed. After a period of osseointegration, the provisional prosthesis was replaced by a definitive prosthesis with a titanium framework made using computer-aided design/computer-assisted manufacturing (CAD/CAM) technology. Judgment criteria were the implant success rate, the provisional prosthesis success rate, and the definitive prosthetic success rate. Results: Two hundred and forty-two implants were placed in 48 patients. Five implants were lost, resulting in an implant survival at 2 years of 97.9%. Two provisional fixed prosthesis had to be temporarily replaced by a removable solution, resulting in a provisional prosthesis success rate of 95.8%. The definitive prosthesis success rate was 100%. Discussion: Use of a provisional prosthesis during the osseointegration period is essential, both for the preparation of the final prosthesis as well as for proper management of potential implant failures. Implant failures are more easily managed if at least five implants were originally placed

Congenital Midline Upper Lip Sinuses

International audienceCongenital sinuses of the upper lip are rare congenital malformations. There have been only 40 cases described in the literature. We report 3 cases of congenital midline upper lip sinus in Caucasian children. Two of those lesions were associated with other anomalies (complete cleft palate and hemifacial macrosomia or submucous cleft palate with bifid uvula). The pathophysiology remains unexplained yet. Congenital upper lip sinuses can be considered as possible microforms of cleft-lips. Associated anomalies are frequent and must be sought. The treatment is a full excision of the sinus tract and of the skin around the punctum in order to avoid risks of recurrence

Management of non-syndromic craniosynostoses in France in 2015: A national survey

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Molecular mechanism of hypoxia-induced chondrogenesis and its application in in vivo cartilage tissue engineering.

International audienceCartilage engineering is one of the most challenging issue in regenerative medicine, due to its limited self-ability to repair. Here, we assessed engineering of cartilage tissue starting from human bone marrow (hBM) stem cells under hypoxic environment and delineated the mechanism whereby chondrogenesis could be conducted without addition of exogenous growth factors. hBM stem cells were cultured in alginate beads and chondrogenesis was monitored by chondrocyte phenotypic markers. Activities and roles of Sox and HIF-1α transcription factors were investigated with complementary approaches of gain and loss of function and provided evidences that HIF-1α is essential for hypoxic induction of chondrogenesis. Thereafter, hBM cells and human articular chondrocytes (HAC) underwent chondrogenesis by 3D and hypoxic culture for 7 days or by ectopic expression of HIF-1α. After subcutaneous implantation of 3 weeks into athymic mice, tissue analysis showed that hypoxia or HIF-1α overexpression is effective and sufficient to induce chondrocyte phenotype in hBM cells, without use of exogenous growth factors. Therefore, this study brings interesting data for a simple and affordable system in biotechnology of cartilage engineering

Comparative study of chondrosarcomas response to DNA damage. Impact of HIF2 expression

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Comparative study of chondrosarcomas response to DNA damage. Impact of HIF2 expression

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