Phenolic composition of artichoke waste and its antioxidant capacity on differentiated Caco-2 cells

Artichoke waste represents a huge amount of discarded material. This study presents the by-products (bracts, exterior leaves, and stalks) of the “Blanca de Tudela” artichoke variety as a potential source of phenolic compounds with promising antioxidant properties. Artichoke residues were subjected to different extraction processes, and the antioxidant capacity and phenolic composition of the extracts were analyzed by spectrophotometric methods and high performance liquid chromatography (HPLC) analyses, respectively. The most abundant polyphenols in artichoke waste were chlorogenic acid, luteolin-7-O-rutinoside, and luteolin-7-O-glucoside. Minor quantities of cynarin, luteolin, apigenin-7-O-glucoside, apigenin-7-O-rutinoside, and naringenin-7-O-glucoside were also found. The antioxidant activity of the obtained extracts determined by ABTS [2, 2’-azinobis (3-ethylbenzothiazoline-6-sulphonic acid)], DPPH (2, 2-diphenyl-1-pycrilhydracyl), and FRAP (Ferric Ion Reducing Antioxidant Power) was highly correlated with the total concentration of phenolic compounds. Chlorogenic acid, luteolin-7-O-glucoside, and luteolin-7-O-rutinoside, the most abundant compounds in 60% methanol extracts, are the components most responsible for the antioxidant activity of the artichoke waste extracts. The extract with the best antioxidant capacity was selected to assay its antioxidant potential on a model intestinal barrier. This action of the hydroxycinnamic acids on intestinal cells (Caco-2) was confirmed. In summary, artichoke waste may be considered a very interesting ingredient for food functionalization and for therapeutic purposes

Grape stem extracts with potential anticancer and antioxidant properties

The application of plant extracts for therapeutic purposes has been used in traditional medicine because plants contain bioactive compounds with beneficial properties for health. Currently, the use of these compounds that are rich in polyphenols for the treatment and prevention of diseases such as cancer, diabetes, and cardiovascular diseases, many of them related to oxidative stress, is gaining certain relevance. Polyphenols have been shown to have antimutagenic, antioxidant, and anti-inflammatory properties. Therefore, the objective of the present work was to study the potential effect of grape stem extracts (GSE), rich in phenolic compounds, in the treatment of cancer, as well as their role in the prevention of this disease associated with its antioxidant power. For that purpose, three cancer lines (Caco-2, MCF-7, and MDA-MB-231) were used, and the results showed that grape stem extracts were capable of showing an antiproliferative effect in these cells through apoptosis cell death associated with a modification of the mitochondrial potential and reactive oxygen species (ROS) levels. Additionally, grape stem extracts showed an antioxidant effect on differentiated intestinal cells that could protect the intestine from diseases related to oxidative stress. Therefore, grape extracts contain bioactive principles with important biological properties and could be used as bio-functional food ingredients to prevent diseases or even to improve certain aspects of human health

A comprehensive survey on 'circular polarized antennas' for existing and emerging wireless communication technologies

Circular polarized (CP) antennas are well suited for long-distance transmission attainment. In order to be adaptable for beyond 5G communication, a detailed and systematic investigation of their important conventional features is required for expected enhancements. The existing designs employing millimeter wave, microwave, and ultra-wideband (UWB) frequencies form the elementary platform for future studies. The 3.4-3.8 GHz frequency band has been identified as a worthy candidate for 5G communications because of spectrum availability. This band comes under UWB frequencies (3.1-10.6 GHz). In this survey, a review of CP antennas in the selected areas to improve the understanding of early-stage researchers specially experienced antenna designers has presented for the first time as best of our knowledge. Design implementations involving size, axial ratio, efficiency, and gain improvements are covered in detail. Besides that, various design approaches to realize CP antennas including (a) printed CP antennas based on parasitic or slotted elements, (b) dielectric resonator CP antennas, (c) reconfigurable CP antennas, (d) substrate integrated waveguide CP antennas, (e) fractal CP antennas, (f) hybrid techniques CP antennas, and (g) 3D printing CP antennas with single and multiple feeding structures have investigated and analyzed. The aim of this work is to provide necessary guidance for the selection of CP antenna geometries in terms of the required dimensions, available bandwidth, gain, and useful materials for the integration and realization in future communication systems

Métodos de medida de la presión arterial disponibles en la farmacia comunitaria para el cribado y seguimiento de la hipertensión arterial

La medida de la presión arterial (PA) en la consulta médica (PAC) ha sido durante muchos años el método de referencia para realizar el diagnóstico, seguimiento y tomar las decisiones clínicas en el manejo de la hipertensión arterial (HTA). Por otra parte, la medida de la PA en la farmacia comunitaria es un método poco estudiado y su utilidad en la práctica clínica es, cuando menos, desconocida. La aparición de la automedida domiciliariade la PA (AMPA) y de la monitorización ambulatoria de la PA (MAPA) ha permitido superar muchas de las limitaciones inherentes a la medida de la PAC, principalmente al proporcionar múltiples medidas de PA exentas del efecto de bata blanca. Además, estos métodos han demostrado relacionarse más estrechamente que la medida de la PAC con el pronóstico cardiovascular y la lesión de órganos diana. En definitiva, la AMPA y la MAPA proporcionan una evaluación más precisa (p. ej., del riesgocardiovascular o del efecto de los tratamientos antihipertensivos) y un mejor manejo del paciente con HTA. El presente artículo ofrece una visión actualizada sobre el interés de los distintos métodos de medida de la PA disponibles en la farmacia para el cribado y seguimiento del paciente hipertenso

Optimum power transfer in RF front end systems using adaptive impedance matching technique

Matching the antenna's impedance to the RF-front-end of a wireless communications system is challenging as the impedance varies with its surround environment. Autonomously matching the antenna to the RF-front-end is therefore essential to optimize power transfer and thereby maintain the antenna's radiation efficiency. This paper presents a theoretical technique for automatically tuning an LC impedance matching network that compensates antenna mismatch presented to the RF-front-end. The proposed technique converges to a matching point without the need of complex mathematical modelling of the system comprising of non-linear control elements. Digital circuitry is used to implement the required matching circuit. Reliable convergence is achieved within the tuning range of the LC-network using control-loops that can independently control the LC impedance. An algorithm based on the proposed technique was used to verify its effectiveness with various antenna loads. Mismatch error of the technique is less than 0.2%. The technique enables speedy convergence (<5 s) and is highly accurate for autonomous adaptive antenna matching networks

Métodos de medida de la presión arterial disponibles en la farmacia comunitaria para el cribado y seguimiento de la hipertensión arterial

La medida de la presión arterial (PA) en la consulta médica (PAC) ha sido durante muchos años el método de referencia para realizar el diagnóstico, seguimiento y tomar las decisiones clínicas en el manejo de la hipertensión arterial (HTA). Por otra parte, la medida de la PA en la farmacia comunitaria es un método poco estudiado y su utilidad en la práctica clínica es, cuando menos, desconocida. La aparición de la automedida domiciliariade la PA (AMPA) y de la monitorización ambulatoria de la PA (MAPA) ha permitido superar muchas de las limitaciones inherentes a la medida de la PAC, principalmente al proporcionar múltiples medidas de PA exentas del efecto de bata blanca. Además, estos métodos han demostrado relacionarse más estrechamente que la medida de la PAC con el pronóstico cardiovascular y la lesión de órganos diana. En definitiva, la AMPA y la MAPA proporcionan una evaluación más precisa (p. ej., del riesgocardiovascular o del efecto de los tratamientos antihipertensivos) y un mejor manejo del paciente con HTA. El presente artículo ofrece una visión actualizada sobre el interés de los distintos métodos de medida de la PA disponibles en la farmacia para el cribado y seguimiento del paciente hipertenso

Available measurement methods of blood pressure at the community pharmacy for the screening and follow up of hypertension

The blood pressure (BP) measurement in the physician's office has been for many years the gold standard for diagnosis, monitoring and making clinical decisions in the management of hypertension. On the other hand, few studies analyze the usefulness of the community pharmacy BP measurement method, which remains unknown in clinical practice. Home and ambulatory BP monitoring (HBPM and ABPM, respectively) have overcome many of the inherent limitations of the BP measurement at the physician's office, mainly providing multiple BP readings exempt from the white coat effect. Additionally, these methods have shown to be better predictors of end-organ damage and cardiovascular outcome than BP measured in the physician's office. Finally, the use of HBPM or ABPM enables a more accurate assessment and an improved management of hypertension. This article provides an overview update on the interest of the different BP measurement methods available in the community pharmacy for the screening and monitoring of hypertensive patients

A Comprehensive Survey on 'Various Decoupling Mechanisms with Focus on Metamaterial and Metasurface Principles Applicable to SAR and MIMO Antenna Systems'

Nowadays synthetic aperture radar (SAR) and multiple-input-multiple-output (MIMO) antenna systems with the capability to radiate waves in more than one pattern and polarization are playing a key role in modern telecommunication and radar systems. This is possible with the use of antenna arrays as they offer advantages of high gain and beamforming capability, which can be utilized for controlling radiation pattern for electromagnetic (EM) interference immunity in wireless systems. However, with the growing demand for compact array antennas, the physical footprint of the arrays needs to be smaller and the consequent of this is severe degradation in the performance of the array resulting from strong mutual-coupling and crosstalk effects between adjacent radiating elements. This review presents a detailed systematic and theoretical study of various mutual-coupling suppression (decoupling) techniques with a strong focus on metamaterial (MTM) and metasurface (MTS) approaches. While the performance of systems employing antenna arrays can be enhanced by calibrating out the interferences digitally, however it is more efficient to apply decoupling techniques at the antenna itself. Previously various simple and cost-effective approaches have been demonstrated to effectively suppress unwanted mutual-coupling in arrays. Such techniques include the use of defected ground structure (DGS), parasitic or slot element, dielectric resonator antenna (DRA), complementary split-ring resonators (CSRR), decoupling networks, P.I.N or varactor diodes, electromagnetic bandgap (EBG) structures, etc. In this review, it is shown that the mutual-coupling reduction methods inspired By MTM and MTS concepts can provide a higher level of isolation between neighbouring radiating elements using easily realizable and cost-effective decoupling configurations that have negligible consequence on the arrays characteristics such as bandwidth, gain and radiation efficiency, and physical footprint

Metamaterial-inspired antenna array for application in microwave breast imaging systems for tumor detection

This paper presents a study of a planar antenna-array inspired by the metamaterial concept where the resonant elements have sub-wavelength dimensions for application in microwave medical imaging systems for detecting tumors in biological tissues. The proposed antenna consists of square-shaped concentric-rings which are connected to a central patch through a common feedline. The array structure comprises several antennas that are arranged to surround the sample breast model. One antenna at a time in the array is used in transmission-mode while others are in receive-mode. The antenna array operates over 2-12 GHz amply covering the frequency range of existing microwave imaging systems. Measured results show that compared to a standard patch antenna array the proposed array with identical dimensions exhibits an average radiation gain and efficiency improvement of 4.8 dBi and 18%, respectively. The average reflection-coefficient of the array over its operating range is better than S-11 <= -20 dB making it highly receptive to weak signals and minimizing the distortion encountered with the transmission of short duration pulse-trains. Moreover, the proposed antenna-array exhibits high-isolation on average of 30dB between radiators. This means that antennas in the array (i) can be closely spaced to accommodate more radiators to achieve higher-resolution imaging scans, and (ii) the imagining scans can be done over a wider frequency range to ascertain better contrast in electrical parameters between malignant tumor-tissue and the surrounding normal breast-tissue to facilitate the detection of breast-tumor. It is found that short wavelength gives better resolution. In this experimental study a standard biomedical breast model that mimics a real-human breast in terms of dielectric and optical properties was used to demonstrate the viability of the proposed antenna over a standard patch antenna in the detection and the localization of tumor. These results are encouraging for clinical trials and further refinement of the antenna-array

Bandwidth and gain enhancement of composite right left handed metamaterial transmission line planar antenna employing a non foster impedance matching circuit board

The paper demonstrates an effective technique to significantly enhance the bandwidth and radiation gain of an otherwise narrowband composite right/left-handed transmission-line (CRLH-TL) antenna using a non-Foster impedance matching circuit (NF-IMC) without affecting the antenna's stability. This is achieved by using the negative reactance of the NF-IMC to counteract the input capacitance of the antenna. Series capacitance of the CRLH-TL unit-cell is created by etching a dielectric spiral slot inside a rectangular microstrip patch that is grounded through a spiraled microstrip inductance. The overall size of the antenna, including the NF-IMC at its lowest operating frequency is 0.335 lambda (0)x0.137 lambda (0)x0.003 lambda (0), where lambda (0) is the free-space wavelength at 1.4 GHz. The performance of the antenna was verified through actual measurements. The stable bandwidth of the antenna for |S-11|<= -18 dB is greater than 1 GHz (1.4-2.45 GHz), which is significantly wider than the CRLH-TL antenna without the proposed impedance matching circuit. In addition, with the proposed technique the measured radiation gain and efficiency of the antenna are increased on average by 3.2 dBi and 31.5% over the operating frequency band