Efficacy of antioxidant supplementation on sperm quality in men with oligoasthenoteratozoospermia

Introduction Evidence of a positive relationship between the intake of antioxidant supplements and the improvement of sperm parameters has been reported mainly in European and American populations and very little in Asian populations. Hence, we aimed to investigate the association between antioxidant supplement intake (i.e., Profertil®) and sperm parameters in Malaysian men with Oligoasthenoteratozoospermia (OAT). Materials and methods: This is a single-centre retrospective study that investigated a total of 195 men with OAT whose female partners underwent ART treatment between 2016 and 2021. They were divided into 2 groups; a treatment group where male patients received two daily capsules of the antioxidant supplement (Profertil®) for 3 months (n = 92) and a control group where no micronutrient was given to the male partner (n = 103). Sperm parameters, including semen volume, sperm concentration, progressive motility, total motility, and morphology, were analyzed before and after treatment. A Kruskal-Wallis test was performed to compare the median levels of the sperm parameters. A Chi-square test was performed to compare the frequencies of normal morphology between the studied groups. Results: Demographic and baseline characteristics showed no significant differences except for the mean age of the husband and the etiology of infertility (p<0.05). When compared to their baseline sperm quality, men receiving Profertil® had highly significant increases in median sperm concentration (p<0.0001), motility (p<0.0001), progressive motility (p<0.0001), total sperm count (p<0.0001), total sperm motility (p=0.01) and total progressive motility (p<0.0001). Moreover, sperm abnormality of a total of 24 (26.1%) men improved after receiving Profertil® (p=0.013). Conclusion: Our data showed that antioxidants (Profertil®) have a positive effect on semen parameters in men with OA

Ovarian cancer? Wait for results

She was a 30 years old Para 2 with her last child birth 2 years ago, she had a regular menstrual period and that she was not on any contraceptive method. With a month's history of abdominal distension and a cystic mass of 24 weeks equivalent of gravid uterus, no sign and symptoms of urinary, bowel, cardiac or respirotory problems. With CA 125 of 406, and suggestivesonographic features. The diagnosis of bilateral ovarian tumour with possible liver metastasis could easily be entertained. However total abdominal hysterectomy with bilateral salpingo-oopherectomy specimen showed casseating epithiloid granulomatous inflamation in both tubo-ovarian masses, compatible with tuberculosis. The same features were found on left lymph node peritoneum. AND THESE WERE THE RESULT