Dynamic analysis of the train-bridge interaction: an accurate and efficient numerical method

The dynamic behavior of railway bridges carrying high-speed trains can be analyzed with or without the consideration of the vehicle's own structure. However, due to the amount of kinetic energy carried at high speeds, the train may interact significantly with the bridge, especially when resonance occurs. Equally important is the riding comfort and the stability of the track and train cars, which are usually the most critical limit states in the design of this type of structures. With the aim of studying this problem a computer code was developed, being the interaction between the bridge and the train implemented by means of contact conditions between each train wheel (nodal point) and the structure (point inside a finite element). The treatment of the interaction between a train wheel and a point on the surface of a finite element is directly and efficiently implemented by means of an extended stiffness matrix, which includes stiffness, flexibility and additional terms that stem from the compatibility equations between the displacements of the vehicle and the bridge. This methodology was applied to the study of the dynamic behavior of a bowstring arch bridge and proved to be very accurate and efficien

Development of an efficient finite element model for the dynamic analysis of the train-bridge interaction

The design of high-speed railway bridges comprises a set of demands, from safety and serviceability aspects, to new types of equipment and construction solutions. In order to perform an accurate and realistic evaluation of the corresponding dynamic behavior, adequate analysis tools that take into account the complexity of the train-bridge system are required. These computational tools must be based on efficient algorithms to allow for the completion of detailed dynamic analyses in a reasonable amount of time. The classical methods of analysis may be unsatisfactory in the evaluation of the dynamic effects of the train-bridge system and fully assessment of the structural safety, track safety and passenger comfort. A direct and versatile technique for the simulation of the train-bridge interaction was implemented in the FEMIX code, which is a general purpose finite element computer program. The presented case study is an application of the proposed formulation, which proved to be very accurate and efficient

Fuzzy logic as a decision-making support system for the indication of bariatric surgery based on an index (OBESINDEX) generated by the association between body fat and body mass index

Background: A Fuzzy Obesity Index (OBESINDEX) for use as an alternative in bariatric surgery indication (BSI) is presented. The search for a more accurate method to evaluate obesity and to indicate a better treatment is important in the world health context. BMI (body mass index) is considered the main criteria for obesity treatment and BSI. Nevertheless, the fat excess related to the percentage of Body Fat (%BF) is actually the principal harmful factor in obesity disease that is usually neglected. This paper presents a new fuzzy mechanism for evaluating obesity by associating BMI with %BF that yields a fuzzy obesity index for obesity evaluation and treatment and allows building up a Fuzzy Decision Support System (FDSS) for BSI.

Methods: Seventy-two patients were evaluated for both BMI and %BF. These data are modified and treated as fuzzy sets. Afterwards, the BMI and %BF classes are aggregated yielding a new index (OBESINDEX) for input linguistic variable are considered the BMI and %BF, and as output linguistic variable is employed the OBESINDEX, an obesity classification with entirely new classes of obesity in the fuzzy context as well is used for BSI.

Results: There is a gradual, smooth obesity classification and BSI when using the proposed fuzzy obesity index when compared with other traditional methods for dealing with obesity.

Conclusion: The BMI is not adequate for surgical indication in all the conditions and fuzzy logic becomes an alternative for decision making in bariatric surgery indication based on the OBESINDEX

The Incidence of Reserve Requirements in Brazil: Do Bank Stockholders Share the Burden?

There is consensus in the economic literature that the reserve requirements are a tax levied upon financial intermediation, yet the incidence of the tax remains controversial. In this paper, we test whether changes in reserve requirements in Brazil impact the stock returns of the financial system distinctly from the rest of the economy. We find evidence that Brazilian bank stock returns were affected by changes in reserve requirements on both time deposits and transaction accounts, which implies that the tax burden of required reserves was not fully passed through to banks' borrowers or clients. Stock returns of non-financial firms were also affected by these changes, suggesting that in some cases, reserve requirements on time deposits and transaction accounts served as a non-neutral instrument of monetary or fiscal policy in Brazil.

A nonlinear vehicle-structure interaction methodology with wheel-rail detachment and reattachment

. A vehicle-structure interaction methodology with a nonlinear contact formulation based on contact and target elements has been developed. To solve the dynamic equations of motion, an incremental formulation has been used due to the nonlinear nature of the contact mechanics, while a procedure based on the Lagrange multiplier method imposes the contact constraint equations when contact occurs. The system of nonlinear equations is solved by an efficient block factorization solver that reorders the system matrix and isolates the nonlinear terms that belong to the contact elements or to other nonlinear elements that may be incorporated in the model. Such procedure avoids multiple unnecessary factorizations of the linear terms during each Newton iteration, making the formulation efficient and computationally attractive. A numerical example has been carried out to validate the accuracy and efficiency of the present methodology. The obtained results have shown a good agreement with the results obtained with the commercial finite element software ANSY

Dynamics of localized spins coupled to the conduction electrons with charge/spin currents

The effects of the charge/spin currents of conduction electrons on the dynamics of the localized spins are studied in terms of the perturbation in the exchange coupling $J_{K}$ between them. The equations of motion for the localized spins are derived exactly up to $O(J_{K}^2)$, and the equations for the two-spin system is solved numerically. It is found that the dynamics depends sensitively upon the relative magnitude of the charge and spin currents, i.e., it shows steady state, periodic motion, and even chaotic behavior. Extension to the multi-spin system and its implications including possible ``spin current detector'' are also discussed.Comment: 5 pages, 4 figures, REVTe

Fuzzy logic as a decision-making support system for the indication of bariatric surgery based on an index (MAFOI) generated by the association between body fat and body mass index.

Background: A fuzzy obesity index (MAFOI) for use as an alternative to bariatric surgery indication (BSI) is presented. The search for a more accurate method to evaluate obesity and to indicate a better treatment is important in the world health context. BMI (body mass index) is considered the main criteria for obesity treatment and BSI. Nevertheless, the fat excess related to the percentage of Body Fat (%BF) is actually the principal harmful factor in obesity disease that is usually neglected. This paper presents a new fuzzy mechanism for evaluating obesity by associating BMI with %BF that yields a fuzzy obesity index for obesity evaluation and treatment and allows building up a Fuzzy Decision Support System (FDSS) for BSI. Methods: Seventy-two patients were evaluated for both BMI and %BF. These data are modified and treated as fuzzy sets. Afterwards, the BMI and %BF classes are aggregated yielding a new index (MAFOI) for input linguistic variable are considered the BMI and %BF, and as output linguistic variable is employed the MAFOI, an obesity classification with entirely new classes of obesity in the fuzzy context as well as is used for BSI. Results: There is gradual, smooth obesity classification and BSI when using the proposed fuzzy obesity index when compared with other traditional methods for dealing with obesity.
Conclusion: The BMI is not adequate for surgical indication in all the conditions and fuzzy logic becomes an alternative for decision making in bariatric surgery indication based on the MAFOI

Laboratory experiments on the generation of internal tidal beams over steep slopes

We designed a simple laboratory experiment to study internal tides generation. We consider a steep continental shelf, for which the internal tide is shown to be emitted from the critical point, which is clearly amphidromic. We also discuss the dependence of the width of the emitted beam on the local curvature of topography and on viscosity. Finally we derive the form of the resulting internal tidal beam by drawing an analogy with an oscillating cylinder in a static fluid

Anterior Cingulate MicroRNA Expression Differences in Mood Disorder Patients: Contrasts with Transcriptomic Analyses in an Animal Model of Depression.

Mood disorders were initially recognized as a legitimate illness in Hippocrates’ Aphorisms. Two of the most prevalent and debilitating mood disorders are major depressive disorder (MDD) and bipolar disorder (BP). While a number of studies have established a genetic component to these illnesses, the genomic architecture remains less than clear. Recently, microRNAs—small, non-coding RNAs that act as posttranscriptional regulators of gene expression—have demonstrated dysregulation in psychiatric disease state. Given these data, we hypothesized that miRNAs may exhibit mood-disorder-dependent differential expression in the anterior cingulate cortex (AnCg), a brain region heavily involved in the regulation of mood. In our first set of studies we employed qPCR analyses of 29 miRNAs implicated in psychiatric illness in AnCg of patients with MDD and BP versus controls. We validated a number of miRNAs as dysregulated in these illnesses and subsequently identified (and validated) several mRNA targets of miRNAs dysregulated in disease. Finally, we demonstrated alterations in the steady-state levels of two of these mRNA targets. In a second set of studies we examined the impact of chronic stress on the transcriptomic network in medial prefrontal cortex (mPFC). Chronic stress is a major precipitant of neuropsychiatric illness and induces a number of physiological and genetic changes in a highly brain-region-dependent fashion. Due to this, we hypothesized that chronic stress would have a significant impact on gene expression in mPFC, a brain region centrally involved in stress responses and regulating HPA axis activity. Furthermore, given that mPFC hypofunction is one of the most commonly observed stress-induced deficits, we hypothesized these gene changes would be consistent with mPFC hypofunction. By employing RNA sequencing and high throughput qPCR analyses, we validated a number of mRNA and miRNA transcripts as stress-regulated. We finally constructed a biochemical “interactome” of stress-regulated mRNAs using bioinformatics tools and literature screens that is consistent with chronic stress- induced glutamatergic hypofunction in mPFC. The work outlined in this thesis sheds light on transcriptomic events that occur in in human mood disorders or in animal models of chronic stress, which could be of clinical relevance in understanding the molecular architecture of mood disorders.PhDNeuroscienceUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/120860/1/jazevedo_1.pd