12 research outputs found

    The Beginnings of Islam in Afghanistan:Conquest, Acculturation, and Islamization

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    Living happily ever after::fraternal polyandry, taxes and “the house” in early Islamic Bactria

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    AbstractThis paper is a first attempt at understanding the impact of Islam on families in eighth-century rural Ṭukhāristan (modern-day northern Afghanistan), at the periphery of the late Umayyad and early ʿAbbāsid caliphate. Tukhāristan lay in the ancient region of Bactria, which became the land and city of Balkh after the Islamic conquests of the early seven hundredsad. My analysis is based on a fascinating corpus of legal documents and letters, written in Bactrian and Arabic in the fourth to eighth centuriesad, which were discovered, edited and translated relatively recently. Scholars of Central Asia have tended to discuss the region's early Islamic history within a politico-military framework based on chronicles and prosopographies written in Arabic and/or adapted into Persian centuries after the Muslim conquests. Such narrative sources describe an ideal state defined by genres of Islamic historiography, and come with the usual menu of distortions, simplifications and exoticisms. The documents under review, on the other hand, were written to serve immediate and practical uses; the evidence they offer is devoid of rhetoric, recording aspects of life and social groupings to which we would otherwise have no access. This paper argues that during the transition to Islamic rule (c.ad700–771), Bactrian and Islamic administrative systems co-existed, and significantly affected family life and marriage traditions. Specifically, it is suggested that the early ʿAbbāsid tax system eclipsed the age-old practice of fraternal polyandry here: more by default than by design.</jats:p

    The Coming of Islam to Balkh

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    Sacred Landscape in Medieval Afghanistan:Revisiting the Faḍāʾil-i Balkh

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    Sacred Landscape in Medieval Afghanistan:Revisiting the Faḍāʾil-i Balkh

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    The Coming of Islam to Balkh

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    Reflections on an Orientalist:Alexander Kuhn (1840-88), the Man and his Legacy

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    Alexander Ludvigovich Kuhn (1840–88) was a Russian Orientalist of German-Armenian descent. The most important period of his activity was his service in Central Asia where on behalf of the Turkestan Governorate-General he collected manuscripts, archives and other materials, joining the military campaigns to Kītāb of ShahriSabz, Iskanderkul, Kokand and Khiva. A large number of the manuscripts were sent back to St. Petersburg to the Imperial Public Library, but some never left Kun's possession until they were donated to the Asiatic Museum after his death. Kun was also in charge of the compilation of the famous “Turkistan Albums”—a major collection of photos testifying to the different nationalities and customs that made up the populations of Central Asia. Until now, Kun's biography has been little known to us. The article takes a look into the personal archive of Kun, and describes the man and his motivations and desires.</jats:p

    Comparison of Common Monogenic Defects in a Large Predominantly Antibody Deficiency Cohort

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    Background: Predominantly antibody deficiencies (PADs) are the most common primary immunodeficiencies, characterized by hypogammaglobulinemia and inability to generate effective antibody responses. Objective: We intended to report most common monogenic PADs and to investigate how patients with PAD who were primarily diagnosed as suffering from agammaglobulinemia, hyper-IgM (HIgM) syndrome, and common variable immunodeficiency (CVID) have different clinical and immunological findings. Methods: Stepwise next-generation sequencing and Sanger sequencing were performed for confirmation of the mutations in the patients clinically diagnosed as suffering from agammaglobulinemia, HIgM syndrome, and CVID. Results: Among 550 registered patients, the predominant genetic defects associated with agammaglobulinemia (48 Bruton's tyrosine kinase [BTK] and 6 μ heavy chain deficiencies), HIgM syndrome (21 CD40 ligand and 7 activation-induced cytidine deaminase deficiencies), and CVID (17 lipopolysaccharides-responsive beige-like anchor deficiency and 12 atypical Immunodeficiency, Centromeric instability, and Facial dysmorphism syndromes) were identified. Clinical disease severity was significantly higher in patients with μ heavy chain and CD40 ligand mutations compared with patients with BTK (P = .003) and activation-induced cytidine deaminase (P = .009) mutations. Paralysis following live polio vaccination was considerably higher in patients with μ heavy chain deficiency compared with BTK deficiency (P < .001). We found a genotype-phenotype correlation among patients with BTK mutations regarding clinical manifestation of meningitis and chronic diarrhea. Surprisingly, we noticed that first presentations in most patients with Immunodeficiency, Centromeric instability, and Facial dysmorphism were respiratory complications (P = .008), whereas first presentations in patients with lipopolysaccharides-responsive beige-like anchor deficiency were nonrespiratory complications (P = .008). Conclusions: This study highlights similarities and differences in the clinical and genetic spectrum of the most common PAD-associated gene defects. This comprehensive comparison will facilitate clinical decision making, and improve prognosis and targeted treatment
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