Associations between pre-ART clinical and laboratory characteristics with subsequent TB-IRIS events.

<p>Baseline (pre-ART) characteristics significantly different between patients that developed TB-IRIS events in the follow up and those who did not were assessed to test associations with risk for IRIS in univariate and multinomial logistic models. Relative risks (RR) are for values below or above the threshold levels displayed, which were estimated close to median values for the overall study population. Adjustment was performed for all variables presented and also included age and gender. 95% CI, 95% confidence interval.</p

Pre-ART plasma levels of IL-6 or CRP distiguish individuals at higher risk for TB-IRIS.

<p>(A) Pre-ART plasma concentrations of IL-6 (left panel) and CRP (right panel) were compared between individuals who developed TB-IRIS during study follow up and those who did not using the Mann-Whitney test. (B) Correlation between IL-6 and CRP values was tested in both groups of patients using the Spearman test. In (B), dotted lines represent the median pre-ART values of IL-6 or CRP in the entire study population. Gray areas highlight those patients displaying values for both biomarkers above their respective median values within the study population. (C) The associations between systemic levels of IL-6 and CRP with risk for subsequent TB-IRIS were assessed by univariate and multivariate models. Relative risks (RR) are per standard deviation increase after log₁₀ transformation. RR were adjusted for baseline age, gender, weight, hemoglobin, hematocrit, sputum culture grade, presence of extra pulmonary TB, presence of miliary TB, days to ART initiation, plasma HIV RNA levels and CD4⁺ T-cell count. CI, confidence interval.</p

Baseline characteristics of the study participants.

<p><b>NOTE.</b> Data represent no. (%) of participants unless otherwise specified. ALT, alanine transaminase; AST, aspartate aminotransferase; ATT, anti-tuberculous treatment; EPTB, extra-pulmonary tuberculosis; IQR, interquartile range; RBC, red blood cell; TB, tuberculosis.</p>*<p>The ATT regimens differentiated according to the frequency of drug administration (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0063541#s2" target="_blank">Methods</a> for full discrimination of the regimens).</p

Baseline characteristics of the study population stratified by IRIS status.

<p><b>NOTE.</b> Data represent no. (%) of participants unless otherwise specified. ALT, alanine transaminase; AST, aspartate aminotransferase; ATT, anti-tuberculous treatment; EPTB, extra-pulmonary tuberculosis; IQR, interquartile range; RBC, red blood cell; TB, tuberculosis.</p