The enigmatic role of nucleophosmin in malignant melanoma: Does it have an effect?

Background: Melanoma is quite a heterogeneous group of diseases of the skin. Prognostic markers of tumor behavior are important to precisely assign individual patients for appropriate treatment protocols. Aim: The aim of our first study was to investigate nucleophosmin expression in melanoma patients and to determine its relationship with the tumor characterictics and patient prognosis. Materials and Methods: We analyzed the immunohistochemical expression of nucleophosmin in 55 melanoma patients. The immunostaining pattern was classified into two groups: Diffuse nuclear and nucleolar relocalization. We also investigated the relationship between the expression of nucleophosmin and the clinicopathological parameters sucssh as Clark level, tumor thickness, stage, histological type, location, and survey. Results: In all cases the neoplastic cells were strongly positive for nucleophosmin (14 cases diffuse nuclear, 41 cases nucleolar relocalization). No correlation was demonstrated between the expression pattern of nucleophosmin and the clinicopathological parameters and survey. Conclusions: The implications of our results, nevertheless, are that the immunohistochemical detection of nucleophosmin is not a valuable tool for predicting the outcome of patients with melanoma or identifying subgroups of patients who may be at a higher risk

DOI: 10.14686/buefad.988894 Teaching Socioscientific Issues through Scientific Scenarios: A Case Evaluation Based on Secondary School Students’ Views

The aim of this study is to make a situation assessment of student views on the processing of socioscientific issues through scientific scenarios.As a sample of socioscientific issues, the 'DNA and Genetic Code' unit, which is included in the secondary school science curriculum, was taken as the basis. The study was conducted with 8th grade students in a public school. As a method, a case study was used, which allowed the students' views to be examined in depth. The data were collected with an opinion form and semi-structured interviews. The opinion form data were analysed by content analysis, and semi-structured interviews were analysed by descriptive analysis. At the end of the study about the teaching of the socioscientific issues of ‘DNA and Genetic Code’ unit through scientific scenarios, it was revealed that the students thought that their academic achievement increased, scientific scenarios provided permanent learning, scientific scenarios were effective in associating lessons with daily life, and their awareness of social issues increased. According to the findings obtained from the students, the teaching of socioscientific issues through scientific scenarios increases the interest and motivation towards the lesson, makes the lesson enjoyable and fun, and facilitates understanding. In line with the experiences and findings obtained from the applications, suggestions were made for the use of scientific scenarios in the teaching of socioscientific issues