Histopathologic parameters in chronic rhinosinusitis with nasal polyposis: impact on quality of life outcomes

BackgroundChronic rhinosinusitis (CRS) is a common disease with a significant impact on health-related quality of life (QOL) of the patient. Histologic inflammatory markers in CRS are an important marker in determining the severity of the disease. In this study, we evaluated the association of histopathologic parameters with QOL questionnaires in patients with CRS with nasal polyposis after endoscopic sinus surgery (ESS)

Predictors of neck metastasis in early stage oral cavity cancer

Objective: To identify the effects of clinical and histopathological parameters on neck metastasis in early-stage oral cavity cancers

Effectiveness of Royal Jelly on Tympanic Membrane Perforations: An Experimental Study

WOS: 000207462800019PubMed ID: 19128609Objective: The aim of this study was to evaluate the comparison of the efficacy of royal jelly in a guinea pig tympanic membrane perforation model with untreated and control groups. Study Design: Prospective study using 16 adult guinea pigs. Methods: Each animal underwent subtotal removal of the tympanic membrane in one ear. Animals were divided into two groups of eight animals each. Group A was treated with topical royal jelly, and group B was treated with saline. All opposite right ears were used as the control group. Examination was done by otoendoscopy on days 10, 12, and 14. The healing process was observed under the microscope and photographed for 3 months. Results: There was no significant difference between group A and group B in the incidence of perforation closure. However, after 3 months, the mean thickness of the tympanic membranes was 0.11, 0.07, and 0.08 mm, respectively, in group A, group B, and the control. These results showed a statistically significant difference. Histologically, the tympanic membranes of group A showed marked fibroblastic orientation and well-organized connective tissue. Application of royal jelly improved the success rate of closure, as shown in the present study. Conclusions: This is the first study to investigate the effectiveness of royal jelly in enhancing healing in tympanic membrane perforations. Our study suggests that royal jelly is effective in increasing healing of tympanic membrane perforations in guinea pigs

Relation of hepatitis B core antigen expression with histological activity, serum HBeAg, and HBV DNA levels

Background: Hepatitis B virus (HBV) is a potentially life-threatening liver infection which may progress to liver failure and cirrhosis. Intrahepatic expression patterns of viral antigens detected by immunohistochemistry may have prognostic implications in disease process. Aim: In this study, we aimed to investigate the relationship between the HBV core antigen (HBcAg) expression and histological activity index (HAI), fibrosis, serum hepatitis B e-antigen (HBeAg) status and HBV DNA levels in patients with chronic HBV infection. Materials and Methods: A total of 114 liver biopsies from patients with chronic HBV infection were included in the study. Immunohistochemical expression of HBcAg and its relation with HAI, fibrosis, serum alanine aminotransferase (ALT) levels, HBeAg status and HBV DNA levels were assessed. Results: The presence of nuclear expression of HBcAg did not show any correlations with ALT levels, HAI and fibrosis score. When the groups were categorized according to the HBeAg status, nuclear HBcAg expression was found to be high in HBeAg positive patients. However, HBcAg nuclear expression showed significant correlations with HBV DNA levels and fibrosis scores in HBeAg negative but not HBeAg positive patients. HBV DNA levels were also significantly associated with HAI and fibrosis scores in HBeAg negative patients. Conclusions: Significant differences found between HBeAg positive and negative patients suggest that HBeAg negative disease is different from HBeAg positive disease, and also point outs that in HBeAg negative disease, patients with nuclear HBcAg expression and increased levels of HBV DNA levels are at a higher risk of developing progressive liver disease

The enigmatic role of nucleophosmin in malignant melanoma: Does it have an effect?

Background: Melanoma is quite a heterogeneous group of diseases of the skin. Prognostic markers of tumor behavior are important to precisely assign individual patients for appropriate treatment protocols. Aim: The aim of our first study was to investigate nucleophosmin expression in melanoma patients and to determine its relationship with the tumor characterictics and patient prognosis. Materials and Methods: We analyzed the immunohistochemical expression of nucleophosmin in 55 melanoma patients. The immunostaining pattern was classified into two groups: Diffuse nuclear and nucleolar relocalization. We also investigated the relationship between the expression of nucleophosmin and the clinicopathological parameters sucssh as Clark level, tumor thickness, stage, histological type, location, and survey. Results: In all cases the neoplastic cells were strongly positive for nucleophosmin (14 cases diffuse nuclear, 41 cases nucleolar relocalization). No correlation was demonstrated between the expression pattern of nucleophosmin and the clinicopathological parameters and survey. Conclusions: The implications of our results, nevertheless, are that the immunohistochemical detection of nucleophosmin is not a valuable tool for predicting the outcome of patients with melanoma or identifying subgroups of patients who may be at a higher risk

Correlation of Nm23 and P27 Expression in Nodal Diffuse Large B Cell Lymphomas with Clinicopathologic Parameters and the Effect on Prognosis

Objective: Diffuse large B cell lymphoma (DLBCL) is the most common type of adult lymphoma. No certain histopathological parameter was found, except proliferation index, for predicting prognosis. In hematological malignancies, the prognostic effect of Nm23 expression, which shows metastatic potential in solid tumors, has been researched by a few studies. Loss of p27, a negative regulator of the cell cycle, indicates aggressiveness; however, some studies showed that high expression is relevant to poor prognosis. Here, we aimed to investigate whether they can be used as prognostic markers in DLBCLs