Association of Interleukin-8 Levels with the Development of Uterine Leiomyomas

AbstractObjective: To find out the relationship between Uterine Leiomyoma and IL-8 levels.Methodology: A cross sectional study was conducted on a sample of 100 females (age ranging from25-50 years) including 50 ultrasound confirmed cases of uterine leiomyomas and 50 healthy controlsfor a duration of 6 months. Levels of plasma IL-8 were measured by ELISA technique.Results: Irregular menstrual cycle was reported in about 44% of cases and 11% of controls. Meannumber of fibroids in females was two. 54% of women were found to have small (<2cm) sized fibroidswhile 46% had large sized fibroids. Out of these 78% were intramural and 22% were sub-serosal typeof fibroids. Plasma levels of IL-8 were positively correlated (p=0.001) with Uterine Leiomyomas.Conclusion: IL-8 levels are significantly higher in patients with uterine leiomyomas depicting apositive correlation between IL-8 and the development of fibroids. However, further studies arerequired to better understand the role of IL-8 in the development of fibroids.Keywords: Uterine Leiomyoma; IL-8, Risk Factor

Towards a women\u27s entrepreneurship century: The uae case study

Sheikh Zayed Al Nahyan, the UAE\u27s founding father, has said, Women have the right to work everywhere. Emirati Women play a vital role in family life, and they are part of the ongoing evolution of the UAE. The UAE is remarkable in having the highest rate, around 77%, of women in higher education in the entire world. They have proved that they attain better academic results at every educational level than men. It is no wonder that this increasing number of educated women in the UAE is reflected in the number women entrepreneurs produced, which can affect the economic growth and development of the UAE. Although the context in the UAE encourages women to become entrepreneurs, the participation of men in business growth is greater than that of women, due to the family commitments of women and the long working hours needed to run a business. In this paper, we look at how technology could be used to raise awareness about entrepreneurship among women in the UAE. Interviews have been conducted, the results of surveys have been analyzed, and an interactive application has been developed for this purpose

CuO and CeO2 Nanostructures Green Synthesized Using Olive Leaf Extract Inhibits the Growth of Highly Virulent Multidrug Resistant Bacteria

One of the major challenges of nano-biotechnology is to engineer potent antimicrobial nanostructures (NS) with high biocompatibility. Keeping this in view, we have performed aqueous olive leaf extract mediated one pot facile synthesis of CuO-NS and CeO2-NS. Prepared NS were homogenous, less than 26 nm in size, and small crystallite units as revealed by scanning electron microscopy (SEM) and X-ray diffraction (XRD) analyses. Fourier transform infrared spectroscopy (FTIR) of CuO-NS and CeO2-NS showed typical Cu-O prints around 592–660 cm-1 and Ce-O bond vibrations at 453 cm-1. The successful capping of CuO-NS and CeO2-NS by compounds present in the plant extract was further validated by high performance liquid chromatography (HPLC) and thermal gravimetric analysis (TGA). Active phyto-chemicals from the leaf extract simultaneously acted as strong reducing as well as capping agent in the NS synthesis. NS engineered in the present study showed antibacterial potential at extremely low concentration against highly virulent multidrug-resistant (MDR) gram-negative strains (Escherichia coli, Enterobacter cloacae, Acinetobacter baumannii and Pseudomonas aeruginosa), alarmed by World Health Organization (WHO). Furthermore, CuO-NS and CeO2-NS did not show any cytotoxicity on HEK-293 cell lines and Brine shrimp larvae indicating that the NS green synthesized in the present study are biocompatible

The Nano-Magnetic Dancing of Bacteria Hand-in-Hand with Oxygen

ABSTRACT Magnetotactic bacteria are mostly microaerophilic found at the interface between oxic-anoxic zones. We report a magnetotactic bacterial strain isolated from an oil refinery sludge sample that grows aerobically in simple chemical growth medium, 9K. They open a new window of isolation of magnetic nanoparticles through an easy natural living system

Green Tropical Phytoextracts - Promising Anticancer Alternative

ABSTRACT The anticancer potential of aqueous extracts of tropical plants Ficus deltoidea and Labisia pumila were tested on human prostate carcinoma (DU145) cells. The effects of these extracts on the cells were observed through several tests such as cytotoxicity MTT assay, trypan blue exclusion assay (for cell viability), fluorescence and morphological observations. Both of the plant extracts had a growth repression effect on the cells with different concentrations. The best concentration (1x10-3 μg/mL) was chosen by determining their cytotoxic effects on human prostate cancer as well as fibroblast (normal) cells. The F. deltoidea extract showed more potency and killed the cells faster than L. pumila. Morphologically both extracts affected the cells in a similar way, i.e. the cells became irregular shaped, detached themselves and kept floating in the medium

Pulling the Brakes on Fast and Furious Multiple Drug-Resistant (MDR) Bacteria

Life-threatening bacterial infections have been managed by antibiotics for years and have significantly improved the wellbeing and lifetime of humans. However, bacteria have always been one step ahead by inactivating the antimicrobial agent chemically or by producing certain enzymes. The alarming universal occurrence of multidrug-resistant (MDR) bacteria has compelled researchers to find alternative treatments for MDR infections. This is a menace where conventional chemotherapies are no longer promising, but several novel approaches could help. Our current review article discusses the novel approaches that can combat MDR bacteria: starting off with potential nanoparticles (NPs) that efficiently interact with microorganisms causing fatal changes in the morphology and structure of these cells; nanophotothermal therapy using inorganic NPs like AuNPs to destroy pathogenic bacterial cells; bacteriophage therapy against which bacteria develop less resistance; combination drugs that act on dissimilar targets in distinctive pathways; probiotics therapy by the secretion of antibacterial chemicals; blockage of quorum sensing signals stopping bacterial colonization, and vaccination against resistant bacterial strains along with virulence factors. All these techniques show us a promising future in the fight against MDR bacteria, which remains the greatest challenge in public health care