Aortic distensibility and coronary artery bypass graft patency

<p>Abstract</p> <p>Background</p> <p>Aortic distensibility is an elasticity index of the aorta, and reflects aortic stiffness. Coronary artery disease has been found to be substantially associated with increased aortic stiffness. In this study we aimed to retrospectively analyze the association of angiographically determined aortic distensibility with the patency rates of coronary bypass grafts</p> <p>Methods</p> <p>The study was conducted in the Cardiology department of the Applied Research Centre for Health of Uludağ University. The coronary angiograms of 53 consecutive coronary bypass patients were analysed retrospectively. Aortic distensibility was calculated using the formula: 2 × (change in aortic diameter)/(diastolic aortic diameter) × (change in aortic pressure). The number of stenosed and patent bypass grafts and the patient characteristics like age, risk factors were noted.</p> <p>Results</p> <p>There were 44 male (83%) and 9 female (17%) cases. Eighteen cases had only one saphenous vein grafting. The number of cases with two, three and four saphenous grafting were 18, 11 and 1; respectively. In the control angiograms the number of cases with one, two, three and four saphenous vein graft obstruction were 15 (31.3%), 7 (14.6%), 1 (2.1%) and 1 (2.1%) respectively. The aortic distensibility did not differ in cases with and without saphenous graft occlusion (p > 0.05). Also left internal mammary artery (LIMA) graft patency was not related to the distensibility of the aorta (p > 0.05). We also evaluated the data for cut-off values of 50 and 70 mmHg of pulse pressure and did not see any significant difference between the groups in terms of saphenous or LIMA grafts.</p> <p>Conclusion</p> <p>In this study we failed to show association of angiographically determined aortic distensibility with coronary bypass graft patency in consecutive 53 patients with coronary artery bypass graft surgery (CABG).</p

The importance of echocardiography in patients with mitral stenosis and comparison of findings before and after commissurotomy

Mitral darlığı bulunduğu için komissurotomi endikasyonu konan 20 olguda, ameliyat öncesi ve sonrası ekokardiyogram, karotis trasesi, fonokardiyogram ve EI33 simultan olarak çekildi. Aynı tetkikler kontrol grubunu oluşturan 20 olguda da yapıldı. Sonuç olarak C-E yükseldiği, D-E ve E-P segmenti değerlerinin mitral darlıklı olgulardaki değişimi normal olgulara göre anlamlı bulundu (p<^0.001, p«£0.001, p<^0.00l). Ameliyat öncesi C-E yüksekliği, D-E ve E-F segmenti buğuları ile ameliyat sonrası bulguları karşılaştırıldığında bu üç değerde de anlamlı yükselmeler bulundu

The effect of perindopril treatment on left ventricular wall thickness, mass and diastolic functions in patients with mild and moderate hypertension

Esansiyel Hipertansiyonlu 22 hastaya 4 mg/gün perindopril tedavisi uygulandı. Tedavi öncesi, tedavinin 2. haftası ve 3. ayında ekokardiyografik incelemeler yapıldı. Perindopril tedavisinin 3. ayında interventrikü- ler septumda (11.3±0.9 mm;10.9±0.8 mm)sol ventrikül arka duvarında (11.2±0.7 mm; 1Q.9±0.6 mm) ve sol ventrikül kitlesinde (247.1±38.2mm; 236.2±36 gr) tedavi öncesine göre anlamlı azalmalar bulundu(p< 0.02, p<0.05, p<0.02). Tedavinin 2. haftasındaki sistolik ve diyastölik parametrelerde anlamlı bir değişiklik tesbit edilmedi. Perindoprilin hafif ve ortada derecede hipertan- siyonlu olgularda sol ventrikül duvar kalınlığını ve kitlesini azaltmada etkili bîr ilaç olduğumu etkinin tedavinin 3. ayında görülebileceği sonucuna varıldı

Association of Aortic Diameters with Coronary Artery Disease Severity and Albumin Excretion

Introduction. Aortic diameters, aortic distensibility, microalbuminuria, coronary artery disease which are all together related to vascular aging are investigated in this paper. Methods. Eighty consecutive nondiabetic patients undergoing elective coronary angiography were enrolled into the study. Systolic and diastolic aortic diameters, aortic distensibility, CAD severity by angiogram with the use of Gensini scoring, and albumin excretion rates were determined. Results. Cases with CAD had significantly larger systolic (30,72 ± 3,21 mm versus 34,19 ± 4,03 mm for cases without and with CAD, resp.) and diastolic aortic diameters measured 3 cm above aortic valve compared to patients without CAD (33,56 ± 4,07 mm versus 29,75 ± 3,12 mm). The systolic and diastolic diameters were significantly higher in albuminuria positive patients compared to albuminuria negative patients (p = 0.017 and 0.008, resp., for systolic and diastolic diameters). Conclusion. In conclusion aortic diameters are increased in patients with coronary artery disease and in patients with microalbuminuria. In CAD patients, systolic blood pressure, pulse pressure, aortic systolic and diastolic pressure, and albumin excretion rate were higher and aortic distensibility was lower

Investigation of aspirin resistance of frequency in patients with coronary artery disease by using pfa-100 system

Amaç: Aspirin günümüzde en yaygın kullanılan antitrombotik ilaçtır. Çalışmamızda koroner arter hastalığı (KAH) saptanan olgularda PFA-100 sistemiyle aspirin direncinin (AD) sıklığı değerlendirildi. Gereç ve Yöntem: Çalışmamıza en az 4 hafta süre ile düzenli olarak, 100 mg ve daha fazla Aspirin kullanan koroner anjiyografisi yapılan 97 hasta dahil edildi. Hastalarda PFA-100 sistemi kullanılarak AD saptandı. Bulgular: Tüm olgularımız aspirine yanıt bakımından karşı- laştırıldığında KAH saptananlarda, saptanmayanlara göre AD anlamlı derecede yüksek bulundu. KAH saptanan aspirine dirençli grupta, sigara içiciliği daha fazlaydı, LDL değerleri ve Total Kolesterol/HDL değerleri aspirine duyarlı gruba göre anlamlı derecede yüksekti. KAH saptananlarda AD olanlar kullandıkları aspirin dozu (100mg ve 300mg) açısından karşılaştırıldıklarında iki grup arasında istatistiksel açıdan anlamlı bir fark saptanmamıştır. KAH saptanan olgular tek damar hastalığı olanlar grup 1 (n=21, % 35), iki damar hastalığı olanlar grup 2 (n=16, % 26) ve üç damar hastalığı olanlar grup 3 (n=23, % 38) olmak üzere üç gruba ayrıldı. Üç hasta grubu AD açısından karşılaştırıldıklarında istatistiksel olarak anlamlı farklılık saptanmamıştır. Sonuç: Aspirin tedavisi alan hastalarda cevabın benzer olmadığı gösterildi. KAH saptanan olgularda aspirin cevabı- nın yeterliliğinin her hastada PFA-100 sistemi ile kısa sürede değerlendirilip tedavinin bu sonuçlara göre düzenlenebileceği kanaatine varıldı.Objective: Today aspirin is the most widely used antithrombotic drug. In this study frequency of the aspirin resistance (AR) was evaluated in coronary artery disease (CAD) patients with PFA-100 system. Material and Methods: In the study 97 patients that routinely used 100 mg or higher aspirin for four weeks and that had coronary angiographic examination were included. In the cases with PFA-100 system AR was determined. Results: When all the cases were examined for AR, it was more frequent in the cases with CAD. In the group with CAD, patients with AR more frequently smoked smoking and the LDL and Total Cholesterol/HDL cholesterol levels were significantly higher compared to the aspirin sensitive patients. When the cases with CAD were compared according to the aspirin dose they had (100mg ve 300mg) the two groups did not differ significantly. The patients with CAD were divided into three goups accordıng to the number of dıseased vessels. Group 1 was constituted of cases with one vessel disease (n=21, % 35), group 2 two vessel disease (n=16, % 26) and group 3 was constituted of patients with three vessel disease (n=23, % 38). There no was statistically significant difference in terms of AR among all three groups. Conclusion: As a result, it was shown that the responses were not the same in patients taking aspirin. It was concluded that in cases with CAD adequacy of aspirin response may be quickly evaluated by PFA-100 system and the therapy may be adjusted according to the result

Acute Haemodialysis-induced Changes in Tissue Doppler Echocardiography Parameters

Background: Tissue Doppler imaging (TDI) is a method that determines the tissue motion and velocity within the myocardium. Aims: To characterize acute haemodialysis (HD)-induced changes in TDI-derived indices for patients that have end-stage renal disease (ESRD). Study Design: Cross sectional study. Methods: Conventional echocardiography and TDI methods were applied to study ESRD patients (n=58) before and after HD. Pulmonary venous flow, mitral inflow, and TDI signals of the lateral and septal mitral annulus were examined for the determination of altered left-ventricular diastolic filling parameters. Flow velocities from early- (E) and late-atrial (A) peak transmitral; peak pulmonary vein systolic (S) and diastolic (D); and myocardial peak systolic (Sm) and peak early (Em) and late (Am) diastolic mitral annular velocities were also assessed for changes. Results: Transmitral E and A velocities and the E/A ratio decreased significantly after HD (p<0.001). Pulmonary vein S (p<0.001) and D (p<0.001) velocities decreased, and S/D ratios increased significantly (p=0.027). HD led to a reduction in septal Em (p<0.001), lateral Em (p=0.006), and Am (p<0.001) velocities. Contrary to the decreases in Em and Am, the Em/Am ratio remained unchanged. Conclusion: A single HD session was associated with an acute deterioration in the diastolic parameters. Since the Em/Am ratio remained unchanged, we conclude that this index is a relatively load-independent measure of diastolic function in HD patients

Investigation of aspirin resistance of frequency in patients with coronary artery disease by using pfa-100 system

Amaç: Aspirin günümüzde en yaygın kullanılan antitrombotik ilaçtır. Çalışmamızda koroner arter hastalığı (KAH) saptanan olgularda PFA-100 sistemiyle aspirin direncinin (AD) sıklığı değerlendirildi. Gereç ve Yöntem: Çalışmamıza en az 4 hafta süre ile düzenli olarak, 100 mg ve daha fazla Aspirin kullanan koroner anjiyografisi yapılan 97 hasta dahil edildi. Hastalarda PFA-100 sistemi kullanılarak AD saptandı. Bulgular: Tüm olgularımız aspirine yanıt bakımından karşı- laştırıldığında KAH saptananlarda, saptanmayanlara göre AD anlamlı derecede yüksek bulundu. KAH saptanan aspirine dirençli grupta, sigara içiciliği daha fazlaydı, LDL değerleri ve Total Kolesterol/HDL değerleri aspirine duyarlı gruba göre anlamlı derecede yüksekti. KAH saptananlarda AD olanlar kullandıkları aspirin dozu (100mg ve 300mg) açısından karşılaştırıldıklarında iki grup arasında istatistiksel açıdan anlamlı bir fark saptanmamıştır. KAH saptanan olgular tek damar hastalığı olanlar grup 1 (n=21, % 35), iki damar hastalığı olanlar grup 2 (n=16, % 26) ve üç damar hastalığı olanlar grup 3 (n=23, % 38) olmak üzere üç gruba ayrıldı. Üç hasta grubu AD açısından karşılaştırıldıklarında istatistiksel olarak anlamlı farklılık saptanmamıştır. Sonuç: Aspirin tedavisi alan hastalarda cevabın benzer olmadığı gösterildi. KAH saptanan olgularda aspirin cevabı- nın yeterliliğinin her hastada PFA-100 sistemi ile kısa sürede değerlendirilip tedavinin bu sonuçlara göre düzenlenebileceği kanaatine varıldı.Objective: Today aspirin is the most widely used antithrombotic drug. In this study frequency of the aspirin resistance (AR) was evaluated in coronary artery disease (CAD) patients with PFA-100 system. Material and Methods: In the study 97 patients that routinely used 100 mg or higher aspirin for four weeks and that had coronary angiographic examination were included. In the cases with PFA-100 system AR was determined. Results: When all the cases were examined for AR, it was more frequent in the cases with CAD. In the group with CAD, patients with AR more frequently smoked smoking and the LDL and Total Cholesterol/HDL cholesterol levels were significantly higher compared to the aspirin sensitive patients. When the cases with CAD were compared according to the aspirin dose they had (100mg ve 300mg) the two groups did not differ significantly. The patients with CAD were divided into three goups accordıng to the number of dıseased vessels. Group 1 was constituted of cases with one vessel disease (n=21, % 35), group 2 two vessel disease (n=16, % 26) and group 3 was constituted of patients with three vessel disease (n=23, % 38). There no was statistically significant difference in terms of AR among all three groups. Conclusion: As a result, it was shown that the responses were not the same in patients taking aspirin. It was concluded that in cases with CAD adequacy of aspirin response may be quickly evaluated by PFA-100 system and the therapy may be adjusted according to the result