Role of intravenous lipid emulsions in the management of calcium channel blocker and beta-blocker overdose: 3 years experience of a university hospital

WOS: 000353453200001PubMed ID: 25684131Objectives: The objective of this study was to assess the efficacy of lipid emulsion as antidotal therapy in severe calcium channel blocker (CCB) and beta-blocker (BB) intoxications. Patients and methods: This is a retrospective study in which we have summarized data of patients who were admitted to a university-based emergency department in a period of 3 years and were given intravenous lipid emulsion (ILE) to manage cardiogenic shock due to CCB and BB overdose. Results: We identified 15 patients who received ILE therapy for CCB and BB toxicity. Hospitalization durations variated between 3 and 33 days (mean 7.46 perpendicular to 7.41 days). Drug exposures included CCBs (n = 8, 53.3%), CCBs and paracetamol (n = 1, 6.6%), and BBs (n = 6, 40%). ILE therapy was effective in 12 patients (80%). Three patients (20%) had resistant hypotension, one of whom progressed to pulmonary edema. Adverse effects of ILE therapy were seen in three patients (20%). Two patients underwent mechanical ventilation. Two patients developed hypoxic ischemic encephalopathy, one patient died, and 14 patients (93.3%) were discharged from hospital. Conclusion: There was 93.3% survival in patients receiving ILE for drug-induced cardiovascular collapse. Clinically significant adverse effects were uncommon. We suggest ILE administration for the treatment of cardiogenic shock due to CCB and BB overdose

Vitamin D levels in Cukurova Region

WOS: 000406284600016Purpose: The aim of ths study was to evaluate the increase in the request of plasma 25-hydroxy vitamin D level assay tests in Balcali Hospital of the Cukurova University during last 13 years and levels of 25-hydroxy vitamin D to determine the frequency of deficiency among the regional adult population admitting this hospital. Material and Methods: This study was performed by using pre-recorded electronic files and laboratory results of patients admitted to Balcali Hospital of the Cukurova University between 2003 and 2015. The number of 25-hydroxy vitamin D tests assayed of all ages between 20032015 and the diagnoses, age, gender, sampling, request, acceptance, confirmation times of tests, plasma 25-hydroxy vitamin D were evaluated. Results: The number of 25-hydroxy vitamin D tests assayed in the last 13 years was 77,569. When compared between years 2003-2013, number of 25-hydroxy vitamin D tests was increased 6785%. Mean plasma 25-hydroxy vitamin D levels were found to be higher in men (52.95 +/- 0.92 nmol/L) than women (48.42 +/- 0.54 nmol/L) (p<0.001). Among 6,198 patients included, 24.65% had 25-hydroxy vitamin D insufficiency and 35.95% had 25-hydroxy vitamin D deficiency. Only 15.62% of patients had optimal 25-hydroxy vitamin D levels. Conclusion: Although it is an extremely sunny environment, vitamin D insufficiency is a common and public health problem in Cukurova region. Many diseases may be prevented by education of how to benefit from sunrays and dietery supplements of vitamin D in risky population