1,125 research outputs found
Desarrollo Web Open source para diagnóstico automático de enfermedades
Presentación realizada en el marco del Proyecto PINV18-846: Detección automática de retinopatía diabética utilizando algoritmos neuro-evolutivos. Cuyo objetivo general fue la Detección Automática de Retinopatía Diabética utilizando algoritmos de aprendizaje neuro-evolutivos.CONACYT - Consejo Nacional de Ciencias y TecnologíaPROCIENCI
Detección automática de retinopatía diabética utilizando algoritmos neuro-evolutivos
Presentación realizada en el marco del Proyecto PINV18-846: Detección automática de retinopatía diabética utilizando algoritmos neuro-evolutivos. Cuyo objetivo general fue la Detección Automática de Retinopatía Diabética utilizando algoritmos de aprendizaje neuro-evolutivos.CONACYT - Consejo Nacional de Ciencias y TecnologíaPROCIENCI
Experimental realization of field-induced XY and Ising ground states in a quasi-2D S=1/2 Heisenberg antiferromagnet
High field specific heat, Cp, and magnetic susceptibility, \c{hi},
measurements were performed on the quasi-two dimensional Heisenberg
antiferromagnet [Cu(pyz)2(pyO)2](PF6)2. While no Cp anomaly is observed down to
0.5 K in zero magnetic field, the application of field parallel to the
crystallographic ab-plane induces a lambda-like anomaly in Cp, consistent with
Ising-type magnetic order. On the other hand, when the field is parallel to the
c-axis, Cp and \c{hi} show evidence of XY-type antiferromagnetism. We argue
that it is a small but finite easy-plane anisotropy in quasi-two dimensional
[Cu(pyz)2(pyO)2](PF6)2 that allows the unusual observation of field induced XY
and Ising-type magnetic states.Comment: 4 figure
Long-term decline of the European wild rabbit (Oryctolagus cuniculus) in south-western Spain
The European wild rabbit (Oryctolagus cuniculus) is a species native to the Iberian Peninsula, where it was once extremely abundant. It is considered the most important prey item for the peninsula's assemblage of Mediterranean vertebrate predators, which includes two endangered specialist rabbit feeders, the Spanish imperial eagle (Aquila adalberti) and the Iberian lynx (Lynx pardinus). However, rabbit population trends in Spain have not been accurately documented. In the present study, we analysed trends in a population of European rabbits monitored over 23 years in the Doñana National Park, home to one of the most diverse and densest predator communities in Europe. Rabbit abundance and population trends were estimated using roadside counts. Results show that the rabbit population declined sharply by ∼60% during the first wave of epizootic rabbit hemorrhagic disease (RHD) in 1990. Since then, rabbit numbers have declined at a relatively constant rate and the species has become progressively scarcer in the area. The current population is less than 10% of that before the arrival of RHD. However, after the RHD epizootic we observed increasing intra-annual population recruitment. We hypothesise that density-dependent factors caused by enzootic viral diseases (myxomatosis, RHD) and higher predation of rabbits are the main factors preventing recovery of rabbit numbers. The effects of a decline in the prey species on the ecology of sympatric rabbit predators are discussed, and measures to improve ongoing rabbit conservation efforts are suggeste
Quantum character varieties and braided module categories
We compute quantum character varieties of arbitrary closed surfaces with
boundaries and marked points. These are categorical invariants of a surface , determined by the choice of a braided tensor category
, and computed via factorization homology.
We identify the algebraic data governing marked points and boundary
components with the notion of a {\em braided module category} for ,
and we describe braided module categories with a generator in terms of certain
explicit algebra homomorphisms called {\em quantum moment maps}. We then show
that the quantum character variety of a decorated surface is obtained from that
of the corresponding punctured surface as a quantum Hamiltonian reduction.
Characters of braided -modules are objects of the torus category
. We initiate a theory of character sheaves for quantum
groups by identifying the torus integral of
with the category of equivariant quantum
-modules. When , we relate the mirabolic version of this
category to the representations of the spherical double affine Hecke algebra
(DAHA) .Comment: 33 pages, 5 figures. Final version, to appear in Sel. Math. New Se
Extracellular Administration of BCL2 Protein Reduces Apoptosis and Improves Survival in a Murine Model of Sepsis
Severe sepsis and septic shock are major causes of morbidity and mortality worldwide. In experimental sepsis there is prominent apoptosis of various cell types, and genetic manipulation of death and survival pathways has been shown to modulate organ injury and survival.We investigated the effect of extracellular administration of two anti-apoptotic members of the BCL2 (B-cell lymphoma 2) family of intracellular regulators of cell death in a murine model of sepsis induced by cecal ligation and puncture (CLP). We show that intraperitoneal injection of picomole range doses of recombinant human (rh) BCL2 or rhBCL2A1 protein markedly improved survival as assessed by surrogate markers of death. Treatment with rhBCL2 or rhBCL2A1 protein significantly reduced the number of apoptotic cells in the intestine and heart following CLP, and this was accompanied by increased expression of endogenous mouse BCL2 protein. Further, mice treated with rhBCL2A1 protein showed an increase in the total number of neutrophils in the peritoneum following CLP with reduced neutrophil apoptosis. Finally, although neither BCL2 nor BCL2A1 are a direct TLR2 ligand, TLR2-null mice were not protected by rhBCL2A1 protein, indicating that TLR2 signaling was required for the protective activity of extracellularly adminsitered BCL2A1 protein in vivo.Treatment with rhBCL2A1 or rhBCL2 protein protects mice from sepsis by reducing apoptosis in multiple target tissues, demonstrating an unexpected, potent activity of extracellularly administered BCL2 BH4-domain proteins
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