Development of Power stock exercise for prevention of Locomotive Syndrome

要介護の危険性が高い状態であるロコモティブシンドロームの予防を目的としてストックやポールを活用した「パワー・ストック・エクササイズ」を開発した。この運動プログラムの特長は，健常な中高年者から後期高齢者，低体力者まで様々な体力レベルの方が実施可能なことである。ストックを利用することにより安全に運動することが出来，また運動負荷の調整も可能となる。さらに正しいフォームの獲得にも有効である。トレーニングメニューの中核は「フラミンゴバランス」と「カンガルー運動」と「カモシカステップ」で構成されている。これらの運動プログラムの実践によりバランス機能と筋力，ステップワークの改善が期待される。We developed the exercise program named 'Power stock exercise' for preventing locomotive syndrome. The strong point of this program is that the person of various physical strength levels can carry out. Even the elderly people to whom muscular power fell can practice the exercise. The strong point of this program is safety, and the 2nd strong point is being able to adjust the load of exercise. In addition, stock is utilizable also as an item for gaining the right training form. The main exercise consists of flamingo balance, kangaroo exercise, and antelope step. We think that they are effective in a balance function, the muscular power of the leg, and improvement in a step work. We will verify the effect of this exercise program from now on

Webサイトの健康食品情報の信頼性・信憑性について

The purpose of this study is to evaluate the reliability of Japanese websites providing health food information. We used the search engine "Google Japan". The search keyword was "health food", "health food and lifestyle-related disease", or "health food

Structure of MSPL–inhibitor complex

Infection of certain influenza viruses is triggered when its HA is cleaved by host cell proteases such as proprotein convertases and type II transmembrane serine proteases (TTSP). HA with a monobasic motif is cleaved by trypsin-like proteases, including TMPRSS2 and HAT, whereas the multibasic motif found in high pathogenicity avian influenza HA is cleaved by furin, PC5/6, or MSPL. MSPL belongs to the TMPRSS family and preferentially cleaves [R/K]-K-K-R↓ sequences. Here, we solved the crystal structure of the extracellular region of human MSPL in complex with an irreversible substrate-analog inhibitor. The structure revealed three domains clustered around the C-terminal α-helix of the SPD. The inhibitor structure and its putative model show that the P1-Arg inserts into the S1 pocket, whereas the P2-Lys and P4-Arg interacts with the Asp/Glu-rich 99-loop that is unique to MSPL. Based on the structure of MSPL, we also constructed a homology model of TMPRSS2, which is essential for the activation of the SARS-CoV-2 spike protein and infection. The model may provide the structural insight for the drug development for COVID-19

The opposite effects of fluvoxamine and sertraline in the treatment of psychotic major depression: a case report

<p>Abstract</p> <p>Background</p> <p>Psychotic major depression is a clinical subtype of major depressive disorder. A number of clinical studies have demonstrated the efficacy of the combination of an antidepressant (for example, a tricyclic antidepressant or selective serotonin reuptake inhibitor (SSRI)) and an atypical antipsychotic or electroconvulsive therapy (ECT) in treating psychotic major depression. In several studies, monotherapy of SSRIs such as fluvoxamine has been shown to be effective in the treatment of psychotic major depression.</p> <p>Methods</p> <p>We report on a 36-year-old Japanese woman in whom fluvoxamine (a SSRI with sigma-1 receptor agonist) and sertraline (a SSRI with sigma-1 receptor antagonist) showed the opposite effects on psychotic symptoms in the treatment of psychotic major depression.</p> <p>Results</p> <p>Symptoms of depression and psychosis in the patient who was non-respondent to antipsychotic drugs improved after fluvoxamine monotherapy. At 3 years later, a switch to sertraline from fluvoxamine dramatically worsened the psychotic symptoms in the patient. Then, a switch back to fluvoxamine from sertraline improved these symptoms 1 week after fluvoxamine treatment.</p> <p>Conclusion</p> <p>Doctors should consider the monotherapy of sigma-1 receptor agonist fluvoxamine as an alternative approach to treating psychotic major depression.</p

Keratin Expression in Mammary Paget’s Disease in situ with Intraductal Invasion

We performed immunohistochemical studies of epithelial keratins in intraductal carcinoma in situ (IDCIS) in mammary Paget’s disease (MPD). K7, K8 and K18 were expressed in IDCIS in MPD. However, K19 was not expressed in IDCIS in MPD. Interestingly, K17 was expressed in some tumor cells in IDCIS. K17, a hyperproliferative keratin, may suggest ductal invasion and poor prognosis in MPD