13,938 research outputs found
Failure of Unrestrained Lightly Reinforced Concrete Slabs under Fire, Part II: Verification and Application
Accepted versio
Testing Creditor Moral Hazard in Sovereign Bond Markets: A Unified Theoretical Approach and Empirical Evidence
This paper critically evaluates the existing empirical literature on creditor moral hazard in sovereign bond markets, proposes a unified theoretical approach to test for IMF-induced creditor moral hazard, and provides empirical evidence, using daily sovereign bond market spreads of Indonesia and Korea. The results suggest that IMF-related news regarding program negotiations and approval may be associated with creditor moral hazard, but their impact on spreads is short-lived, indicating that creditor moral hazard could be best described as a short-run phenomenon.Creditor moral hazard, financial markets, the IMF, and news
Complexity Measures from Interaction Structures
We evaluate new complexity measures on the symbolic dynamics of coupled tent
maps and cellular automata. These measures quantify complexity in terms of
-th order statistical dependencies that cannot be reduced to interactions
between units. We demonstrate that these measures are able to identify
complex dynamical regimes.Comment: 11 pages, figures improved, minor changes to the tex
Quantifying structure in networks
We investigate exponential families of random graph distributions as a
framework for systematic quantification of structure in networks. In this paper
we restrict ourselves to undirected unlabeled graphs. For these graphs, the
counts of subgraphs with no more than k links are a sufficient statistics for
the exponential families of graphs with interactions between at most k links.
In this framework we investigate the dependencies between several observables
commonly used to quantify structure in networks, such as the degree
distribution, cluster and assortativity coefficients.Comment: 17 pages, 3 figure
Failure of Unrestrained Lightly Reinforced Concrete Slabs under Fire, Part I: Analytical Models
Accepted versio
D-branes with Lorentzian signature in the Nappi-Witten model
Lorentzian signature D-branes of all dimensions for the Nappi-Witten string
are constructed. This is done by rewriting the gluing condition for
the model chiral currents on the brane as a well posed first order differential
problem and by solving it for Lie algebra isometries other than Lie algebra
automorphisms. By construction, these D-branes are not twined conjugacy
classes. Metrically degenerate D-branes are also obtained.Comment: 22 page
Parametric Fokker-Planck equation
We derive the Fokker-Planck equation on the parametric space. It is the
Wasserstein gradient flow of relative entropy on the statistical manifold. We
pull back the PDE to a finite dimensional ODE on parameter space. Some
analytical example and numerical examples are presented
Photo-Induced Oxidative Stress Impairs Mitochondrial Metabolism in Neurons and Astrocytes
Photodynamic therapy is selective destruction of cells stained with a photosensitizer upon irradiation with light at a specific wavelength in the presence of oxygen. Cell death upon photodynamic treatment is known to occur mainly due to free radical production and subsequent development of oxidative stress. During photodynamic therapy of brain tumors, healthy cells are also damaged; considering this, it is important to investigate the effect of the treatment on normal neurons and glia. We employed live-cell imaging technique to investigate the cellular mechanism of photodynamic action of radachlorin (200Â nM) on neurons and astrocytes in primary rat cell culture. We found that the photodynamic effect of radachlorin increases production of reactive oxygen species measured by dihydroethidium and significantly decrease mitochondrial membrane potential. Mitochondrial depolarization was independent of opening of mitochondrial permeability transition pore and was insensitive to blocker of this pore cyclosporine A. However, irradiation of cells with radachlorin dramatically decreased NADH autofluorescence and also reduced mitochondrial NADH pool suggesting inhibition of mitochondrial respiration by limitation of substrate. This effect could be prevented by inhibition of poly (ADP-ribose) polymerase (PARP) with DPQ. Thus, irradiation of neurons and astrocytes in the presence of radachlorin leads to activation of PARP and decrease in NADH that leads to mitochondrial dysfunction
Shared Information -- New Insights and Problems in Decomposing Information in Complex Systems
How can the information that a set of random variables
contains about another random variable be decomposed? To what extent do
different subgroups provide the same, i.e. shared or redundant, information,
carry unique information or interact for the emergence of synergistic
information?
Recently Williams and Beer proposed such a decomposition based on natural
properties for shared information. While these properties fix the structure of
the decomposition, they do not uniquely specify the values of the different
terms. Therefore, we investigate additional properties such as strong symmetry
and left monotonicity. We find that strong symmetry is incompatible with the
properties proposed by Williams and Beer. Although left monotonicity is a very
natural property for an information measure it is not fulfilled by any of the
proposed measures.
We also study a geometric framework for information decompositions and ask
whether it is possible to represent shared information by a family of posterior
distributions.
Finally, we draw connections to the notions of shared knowledge and common
knowledge in game theory. While many people believe that independent variables
cannot share information, we show that in game theory independent agents can
have shared knowledge, but not common knowledge. We conclude that intuition and
heuristic arguments do not suffice when arguing about information.Comment: 20 page
Lactate and Pyruvate Activate Autophagy and Mitophagy that Protect Cells in Toxic Model of Parkinson's Disease
Intracellular quality control regulated by autophagy process is important for maintenance of cellular homeostasis. Deregulation of autophagy and more specifically mitophagy leads to accumulation of the misfolded proteins and damaged mitochondria that in turn leads to the cell loss. Alteration of autophagy and mitophagy has shown to be involved in the number of disorders including neurodegenerative diseases. Autophagy and mitophagy could be activated by short-time acidification of the cytosol; however, most of the compounds which can induce it are toxic. Here, we tested several organic compounds which are involved in cellular metabolism on their ability to change intracellular pH and induce mitophagy/autophagy. We have found that lactate and pyruvate are able to reduce intracellular pH in non-toxic concentrations. Short-term (2 h) and long-term (24 h) incubation of the cells with lactate and pyruvateinduced mitophagy and autophagy. Incubation of the SH-SY5Y cells or primary neurons and astrocytes with lactate or pyruvate also activated mitophagy and autophagy after MPPâ+âtreatment that led to recovery of mitochondrial function and protection of these cells against apoptotic and necrotic death. Thus, pyruvate- or lactate-induced acidification of cytosol activates cell protective mitophagy and autophagy
- âŠ