Study of the peri-operative mortality in trochanteric fractures in elderly patients (60 years and above) visiting department of orthopedics at Dr. RPGMC Tanda

Background: In elderly, trochanteric fractures are frequent and typically result from mild to moderate trauma in osteoporotic bones while in young adults these fractures are generally due to high energy trauma such as road side accidents.Methods: The present study was conducted in elderly patients with trochanteric fractures (age 60 years and above) presenting to the department of orthopedics, Dr. RPGMC Kangra at Tanda. All cases presenting to the department and fulfilling the inclusion criteria were studied for three months period from the day of surgery. All cases fulfilling the inclusion criteria who were operated over the period of one year from the date of start of study were included.Results: Our study observed that out of 176 patients, 10.23% (n=18/176) patients could not survive within 90 days of surgery while 89.8% (n=158/176) patients survived. Perioperative mortality was 10.23%.Conclusions: In our study, peri-operative mortality is lower than reported earlier. We also found that perioperative mortality was influenced by older age

Knowledge and awareness of orthopaedic surgeons about radiation hazards in operation theatres

Background: Due to increase in geriatric orthopaedic patients minimally invasive soft tissue and orthopaedic surgeries are gaining. But such procedures have increased the surgeon’s dependence on fluoroscopy which has exposed them to ever increasing dosage of ionising radiations (both direct and scattered).Methods: The study was carried out among medical professionals attending annual north zone conference of orthopaedics using a pre-designed questionnaire on a non-probability sample of 200 orthopedicians.  Questionnaires contained 11 MCQs.Results: 62% of the surgeons believed that hands receive maximum amount of C-arm radiations followed by thyroid (25%). 9% of surgeons have answered eyes and 4% say gonads. 31% of surgeons believe that 100 mSv is allowable annual effective whole-body dose of radiation. 15% believe it to be 500 msv. Majority (37%) of the surgeons had no idea on the allowable annual effective whole-body dose of radiation. 30% of surgeons believe that allowable annual effective dose of radiation for hands is 50 msv. Further 23% of the surgeons believe it to be 100 msv. 50% have no idea about this.Conclusions: All orthopaedic residents and surgeons should have more information and knowledge about ionising radiation. Special courses and workshops can be arranged at local, regional and national levels in this regard.

Preferences and Practices regarding Delivery Place: A community-based cross-sectional study in Agra city, Uttar Pradesh

Background: Understanding preferences and practices for delivery place among women would assist in better resource utilization for skilled attendants. Objectives: To study factors influencing women’s preference and practice regarding their place of delivery. Methods: A community based cross-sectional study was conducted in Agra from 1st October 2018 to 31st October 2020. Multi-stage random sampling was used. Data was collected using semi-structured interview schedule. Both bivariate and multivariate analysis was done. Result: Majority (72.67%) of women had preference for delivery at government hospital while 19.67% for private hospital and only 7.67% for home. In actual practice, 58.33% had delivered at government hospital and 32.33% delivered at private hospital while 9.33 % at home. On multiple-logistic regression analysis, parity found to have significant association with preference of delivery at government hospital. Preference for delivery in private hospital was found to be significant with OBC caste and in women whose husband has skilled/highly-skilled occupation. In actual practice, Government hospital as delivery place found to have significant association with parity and presence of ASHA. Private hospital as a delivery place found significant with literate mothers and parity. Conclusion: Majority had preferred and practiced institutional delivery, preferring government hospital over private hospital.  In actual practice, delivery at private hospital as well as home delivery out-numbered the preferred proportion

Electrodeposited carbon nanostructured nickel composite coatings: A review

The utilization of high-strength materials that can retain their strength after successive use under high mineral moisture (maximum weight of 1098 kg) for aerospace, automotive, and electromagnetic devices is challenging. Generally, coatings of nickel (Ni) and its alloys are utilized in the aforementioned applications, but the continuous use of the system degrades its mechanical stability and structural integrity. For the automotive and aerospace uses, the material should have high mechanical strength, wear tolerance, corrosion resistance, and magnetism. The bare Ni coatings can be altered with enhanced mechanical, tribological and electrochemical performances by using various reinforcements in the coatings. The abundantly used reinforcing agents are mainly carbonaceous nanoallotropes (such as graphene, carbon nanotubes, and diamond) for the fabrication of composite coatings. The current review unfolds the introduction of nickel and the major cause of damage to bare nickel coatings. Moreover, the review sheds light on how to mitigate the damage of nickel coatings with an emphasis on giving a flavor of distinct carbonaceous nanoallotropes. The conjugated studies on mechanical, wear, corrosion, and magnetic behavior of electrodeposited Ni-carbonaceous composite coatings are embraced in the review. Therefore, the present review can be endorsed by the readers for the protection of aircraft, automotive, and electromagnetic appliances

Determining the association between socio-demographic profile and difficulties encountered during fixation of trochanteric fractures with proximal femoral nailing operated in the department of orthopedics at Dr RPGMC Kangra at Tanda

Background: Trochanteric fractures are one of the commonest fractures seen in elderly people. We conducted a study association between socio-demographic profile and difficulties encountered during fixation of trochanteric fractures with proximal femoral nailing (PFN) operated in the department of orthopedics at Dr RPGMC Kangra at Tanda.Methods: This study was conducted on patients presenting to the department of orthopedics at Dr RPGMC Tanda with trochanteric fractures and fulfilling the criteria and studied for a period of one year starting from the date of study. The patients were clinically evaluated at the time of admission. Demographic data of the patients such as age, sex, pre-operative mobility status, pre-existing co-morbidities, type of fracture/fracture classification, degree of osteoporosis (measured by Singh’s index) were noted.Results: Comparison of age of the patients in which difficulties encountered was comparable to the patients in which no difficulties encountered (p=0.562) 57% (n=33/58) of the patients in which no difficulties encountered were males. Sex-based distribution was not found to be statistically significant (p=0.480). 93% (n=54/58) of the patients in which no difficulties encountered belonged to rural areas. Residence-based distribution was not found to be statistically significant (p=0.506).Conclusions: In this study, we observed that technical difficulty in PFN can arise in any patient irrespective of their age, sex and socioeconomic status

Study on the antioxidant potential of Catharanthus species and its thermal stability in sunflower oil model system

AbstractThe studies analyze the efficiency of Catharanthus alba and Catharanthus roseus cultivars as a natural antioxidant measuring antioxidant potential through two methods. In the first method, antioxidant activity was estimated through the sunflower oil model system in which the Peroxide value (PV) and Thiobarbituric acid (TBA) tests were performed. While in the second method, antioxidant activity estimation is done through the assay method in which 2, 2- Diphenyl- 1-picrylhydrazyl (DPPH) radical scavenging method and ammonium thiocyanate method has been performed. The thermal stability of the leaves & flowers of Catharanthus alba and Catharanthus roseus were analyzed by mixing of powdered medicinal plant and sunflower oil. Further results indicate the higher antioxidant activity of flower Catharanthus alba as compared to flower Catharanthus roseus. Relatively among the leaves, Catharanthus roseus demonstrated slightly higher antioxidant potential than the leaves of Catharanthus alba. The antioxidant activity of Catharanthus alba (Flower)> Catharanthus roseus (Flower)> Catharanthus roseus (leaves)> Catharanthus alba (leaves) has been reported. The dehydrated powders of leaves and flowers of Catharanthus alba and Catharanthus roseus have shown good antioxidant activity at 0.5% level in sunflower oil while increase in concentration up to 1% and 1.5% does not show enhanced antioxidant activity in sunflower oil. The flowers and leaves of both cultivars of Catharanthus have shown good thermal stability when heated at 80 °C continuously for 24 h considering all the parameters with statistical significance of (p ≤ 0.001)

Insights into structural, vibrational, and chemical shift characteristics, solvents impact (polar and nonpolar) on electronic properties and reactive sites, ADMET predictions, and ligand-protein interactions for antiviral drugs safrole and isosafrole: An in-silico approach

The safrole and isosafrole are constitutional isomers that have been theoretically characterized utilizing Density Functional Theory (DFT) employed with the B3LYP/6-311++G(d,p) basis set to simulate geometrical parameters, vibrational aspects, electronic properties, and chemical shifts and explored the solvent effect on electronic spectra of safrole and isosafrole in different solvents, including polar solvents such as acetone, Dimethyl sulfoxide (DMSO), and methanol, nonpolar solvents such as chloroform, cyclohexane, and toluene, and the gas phase using Time Dependent-Density Functional Theory (TD-DFT) methods. In addition, Natural Orbital (NBO), Mulliken population analysis, and Molecular Electrostatic Potential (MEP) surface have been simulated to understand better the reactive sites in the molecular structures of safrole and isosafrole. The frontier molecular orbitals (FMO) energy gaps of safrole and isosafrole were simulated in polar and nonpolar solvents, confirming the safrole and isosafrole kinetic stability and chemical reactivity. The in-silico ADMET indices were utilized to ascertain the probable pharmacokinetic and biological features of safrole and isosafrole. A molecular docking investigation was also conducted to investigate the potential biological activity of safrole and isosafrole against the SARS-CoV-2 spike protein, providing more support for its antiviral efficacy