Comparison Of Outcome And Side Effects Profile Of Treatment Of Overactive Bladder With Different Classes Of Drugs

Objective: Overactive Bladder (OAB) is a common condition characterized by urinary urgency, frequency, and incontinence. Anticholinergics, beta-3 agonists, and mirabegron are commonly used to manage OAB symptoms. Anticholinergics are effective but may cause side effects such as dry mouth, constipation, and drowsiness. Beta-3 agonists, like Mirabegron, are a viable option for individuals seeking to avoid these side effects. Methods: A study of 45 female patients with OAB symptoms was conducted to evaluate the effectiveness of two cross-over protocols. Group A received mirabegron followed by solifenacin, and group B received mirabegron followed by solifenacin. Results: The results showed that both treatments were effective in reducing the symptoms of OAB as measured by the IPSS, OABSS, and VAS scores for emergency and distention. The side effects of dry mouth and constipation were relatively mild. However, a p-value of 0.007 shows that there was no significant difference in effectiveness and side effects between the two groups. Conclusion: Both treatment options can be effective for OAB, but each has specific disadvantages. Consulting with a healthcare provider is important to determine the best treatment option based on an individual's specific needs and medical history

An Efficient Algorithm to Enhance Nonoverlapping Coverage Area with Less Energy Consumption in WSN

Several chargeable sensor nodes are deployed randomly to cover the target points with an efficient heuristic approach for the mobility of sensor nodes in an area of interest (AoI). The heuristic approach generates the cover set that includes the targets for a prolonged time. The cover sets are the subset of the total sensor node area where each set is capable of representing all the targets. The functionality of the sensor nodes depends upon the network lifetime of the target points covering an AoI. The network lifetime would improve by reducing the consumption of battery power through heuristic process. The proposed heuristic process can do this by generating cover sets and selecting sensor nodes with the highest remaining battery power. These cover sets remove the redundant sensor node in an AoI that causes the overlapping issue and assign the maximum lifetime which is the minimum amount of battery power of the sensor node, participating in the cover set. The results show the improvement in the mobility of sensor nodes by coverage and attain maximum network lifetime as compared to the existing algorithms

Role of alternative phosphorylation and O-glycosylation of erythropoietin receptor in modulating its function: an in silico study

Detailed knowledge of the three-dimensional (3D) structure of a protein is essential for the proper understanding of its function(s) that could be modified through posttranslational modifications (PTMs). Among these PTMs, alterations of serine/threonine residues of a protein through phosphorylation and O-glycosylation are extremely dynamic and could modulate the functions of a protein by affecting their 3D structure. Potential of a protein for certain PTMs could be evaluated through computer-based methods. Erythropoietin (EPO) is a multifunctional protein that primarily regulates red blood cell production and is also involved in other nonhematopoietic functions; for example, EPO also has cardioprotective and neuroprotective effects. In this study, multifunctional EPO behavior has been revealed based on transient modifications of its receptor. In this study, PTMs of erythropoietin receptor (EPO-R) were predicted using neural network tools, and the possible effects of these modifications are suggested. Phosphorylation and O-glycosylation at serine 380 and 444 of the cytoplasmic domain of EPO-R seem to have an antagonistic role in controlling signaling events induced by EPO. O-glycosylation at threonine 423 might hinder beta-TrCP (a ubiquitin ligase) binding, which ubiquitinates at K 428, and ultimately results in the recycling of EPO-R, thus increasing EPO sensitivity. In contrast, the phosphorylated form of the same residue inhibits the recycling of EPO-R and thereby decreases the EPO sensitivity. Additionally, the interplay of O-glycosylation modification at serine 478 and phosphorylation at tyrosine 479 might help in controlling the duration of EPO-induced signaling

Investigating the effect of Aspergillus niger inoculated press mud (biofertilizer) on the potential of enhancing maize (Zea mays. L) yield, potassium use efficiency and potassium agronomic efficiency

Globally field application of mineral potassium (K) fertilizer has grown, followed by reduced K use efficiency (KUE) and K agronomic efficiency (KAE) which ultimately leads to environmental pollution and economic loss. The soils of Pakistan have a low K level due to a higher proportion is present in an unavailable form. The objective of the current study was to isolate efficient plant growth-promoting fungus to sustainably manage huge burden of sugar industry waste press mud into a productive biofertilizer. K from biofertilizer was then evaluated in different treatments for maize biological yield, grain yield, harvest index (HI), K uptake in different maize parts, KUE and KAE in comparison to mineral fertilizer (MF). The efficiency of treatment was measured on higher KUE and KAE. In-vitro studies revealed that A. niger PM-4 was found to solubilize phosphate (389 ug/ml) and zinc (115 ug/ml) from insoluble tri-calcium phosphate and zinc oxide, respectively, at a wider temperature and pH range. The strain was also found to inhibit the production of aflatoxins and its inoculation into press mud produced non-phytotoxic and mature biofertilizer with germination index 96.5%. Bio-augmentation of press mud with A. niger shortens maturity period with improved nutrient contents. Higher grain yield and harvest index of maize were achieved with a higher amount of incorporated K from mineral and biofertilizer T5(100%Org+50%MF) than any other treatment. However, higher KUE and KAE were found in the following order: T6 > T5 > T2 > T3 > T4 > T1, demonstrating the integrated and balanced use of K from mineral and biofertilizer without threatening the environment