Performance of PIXE Technique through a Geochemical Analysis of High Grade Rocks

It has been an argument that some of the elements present in geological material by using PIXE analysis are purely determined or could not be determined at all, due to various reasons including the matrix. It is felt that a systematic investigation needs to be designed and implemented to understand the limitation of PIXE in certain elements. The high-grade rocks selected are analyzed both by PIXE as well as AAS and the results are authenticated by using a USGS reference material, Basalt, studies of literature. It is believed that the accuracy of problematic elements, especially from high grade rock can be improved and the conditions of PIXE can be standardized for various elements under different combinations. The reasons behind the poor performance of Proton Induced X- ray Emission in case of certain elements have been established

Synthesis, characterization and in vitro biological evaluation of some new 1,3,5-triazine-chalcone hybrid molecules as Mycobacterium tuberculosis H37Rv inhibitors

A novel series of 1,3,5-triazine-chalcone hybrid molecules (4a-ii) have been synthesized and evaluated in vitro for Mycobacterium tuberculosis H37Rv inhibitory potency using Alamar blue assay and the activity expressed as the minimum inhibitory concentration (MIC) in µg/mL. The antitubercular activity screening data revealed that the compound 4z demonstrated comparatively the most potent inhibitory activity, with MIC value 3.125 µg/mL. It is noteworthy that the compounds 4e, 4p and 4bb also showed appreciable inhibitory activity with MIC value 6.25 µg/mL. Most of the compounds displayed significantly promising activity and their structure-activity relationships were also discussed. This could be the remarkable starting point to develop new lead molecules with potential antitubercular activity

Synthesis, characterization and in vitro evaluation of some new 5-benzylidene-1,3-thiazolidine-2,4-dione analogs as new class of α-glucosidase inhibitors

A series of 5-benzylidene-1,3-thiazolidine-2,4-dione derivatives (5a-u) were synthesized and tested against α-glucosidase. Preparation of the titled compounds was achieved by reaction of (Z)-4-((2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl)benzaldehyde (4) and aromatic/hetero aromatic ketone. Among the compounds tested, (5p) and (5o) were identified as the most active in vitro with minimum inhibitory concentration (MIC) of 6.56±0.81 and 8.92±0.21 µg/mL against α-glucosidase, respectively. Evaluation of the structure activity relationship of substituents within these series has followed the discovery of a variety of compounds

Synthesis, characterization and in vitro biological evaluation of some new diarylsulfonylurea-chalcone hybrids as potential 5-lipoxygenase inhibitors

A series of some new diarylsulfonylurea-chalcone hybrids (4a-4y) have been synthesized via Claisen-Schmidt condensation reaction by treating 1-(3-acetylphenyl)-3-tosylurea with various aromatic/heteroaromatic aldehydes in the presence of alkali and characterized by FT-IR, 1H NMR, 13C NMR and LC mass spectral analysis. All the synthesized compounds were evaluated for their in vitro 5-Lipoxygenase inhibitory activity using potato 5-lipoxygenase enzyme. Among the tested compounds 4r and 4o exhibited significant inhibitory activity at IC50 values 7.88±0.14 and 11.77±0.21 µg/mL, respectively. This level of activity was found comparable to that of the reference drug Abietic acid (LI01020) with IC50 value 4.34±0.37 µg/mL and it could be a remarkable starting point to develop new lead molecules

Ligand-Target Interaction Diagrammes: Baicalein Analogues as SARS-CoV-2 Main Protease (Mpro) Inhibitors

Ligand-Target Interaction Diagrammes generated based on the Glide HTVS/SP/XP Molecular Docking-based Virtual Screening Hits of Baicalein Analogues as SARS-CoV-2 Main Protease (Mpro) Inhibitors.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

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Not AvailableChitinolytic Bacillus and associated chitinases have prospective implication in both industry and biological control of agricultural pests. A total of 83 chitinolytic Bacillus strains were isolated from native soils of Uttarakhand state, north western Indian Himalayas. A multiphasic characterization of the collection showed a vast diversity in bacterial kinetics (growth and enzyme production), pH stability in ten isolates, thermal-stability in 23 isolates and psychrotolerance in three isolates. The collection was characterized by chief existence of 148 kDa (65 isolates) and 152 kDa (7 isolates) chitinases, the high molecular weight enzymes. Partial sequencing of 16S rRNA and chi genes showed Paenibacillus species are the major chitinase producers of the region. In addition, licheniformis and circulans group chitinases were also found to be associated with the collection. The molecular variation in sequences revealed existence of different Paenibacillus species and especially a special evolutionary status of chitinases in phylogeny which is also evidenced by associated high molecular weight chitinases. The bioactivity of isolates against insect pests, Pieris brassicae and Helicoverpa armigera showed that the isolates were not lethal except at very high concentrations (108 cfu/ml) that to in only 9 isolates. However, they are primarily involved in growth reduction which led to identification of three prominent isolates (UKCH27, UKCH29 and UKCH77) that caused a significant larval weight reduction at lowest concentration tested (102 cfu/ml). Further testing of synergism between Cry toxins of B. thuringiensis strain HD 1 and these isolates showed near cent percent mortality of test insects at LC30 concentrationsNot Availabl