20 research outputs found

    On the Deformation of Dendrites During Directional Solidification of a Nickel-Based Superalloy

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    Abstract: Synchrotron X-ray imaging has been used to examine in situ the deformation of dendrites that takes place during the solidification of a nickel-based superalloy. By combining absorption and diffraction contrast imaging, deformation events could be classified by their localization and permanence. In particular, a deformation mechanism arising from thermal contraction in a temperature gradient was elucidated through digital image correlation. It was concluded that this mechanism may explain the small misorientations typically observed in single crystal castings

    Neonatal Fc Receptor: From Immunity to Therapeutics

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    The neonatal Fc receptor (FcRn), also known as the Brambell receptor and encoded by Fcgrt, is a MHC class I like molecule that functions to protect IgG and albumin from catabolism, mediates transport of IgG across epithelial cells, and is involved in antigen presentation by professional antigen presenting cells. Its function is evident in early life in the transport of IgG from mother to fetus and neonate for passive immunity and later in the development of adaptive immunity and other functions throughout life. The unique ability of this receptor to prolong the half-life of IgG and albumin has guided engineering of novel therapeutics. Here, we aim to summarize the basic understanding of FcRn biology, its functions in various organs, and the therapeutic design of antibody- and albumin-based therapeutics in light of their interactions with FcRn

    Origins of misorientation defects in single crystal castings: A time resolved in situ synchrotron X-ray radiography study

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    International audienceThe presence of grain boundaries in single crystal castings is intolerable owing to the detrimental impact on creep and fatigue behaviour. Whilst the origins of many defects such as freckles have been understood since the 1970s, other defects such as slivers, or indeed the small mosaicity observed in many castings have eluded comprehensive treatments. In the present work, in situ X-ray imaging has been used to examine the origin of misorientation defects that arise during solidification. Dendrite deformation was observed, which impacted growth characteristics and led to a permanent misoriention. Digital image correlation analysis showed the dendrites becoming increasingly bent as solidification progressed. In order to probe the deformation modes further, a method was devised to convert standard EBSD data into measurements of bending and torsion angle.It was demonstrated that such defects form as the result of bending moments arising from differential thermal contraction and gravity

    Observation of the initiation and propagation of solidification cracks by means of in situ synchrotron X-ray radiography

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    International audienceWe report on the in situ, time resolved, observation of solidication cracking in a thin sample of an Al-15wt%Sn alloy at ESRF BM05. During the experiment, solidification cracking was seen to occur during natural cooling of the sample at a solid fraction of 95%, between directionally agglomerated dendritic networks. Through detailed analysis, three stages of crack growth were observed: crack initiation, which typically occurs asymmetrically with the liquid lm separating from one side of the dendritic network prior to full detachment; crack propagation, where the liquid lm generally detaches from both sides simultaneously; and crack coalescence. We correlate our observations using scanning electron microscopy, which shows that voids between grains, and also spikes, can appear asymmetrically on either side of the crack surface
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