Peculiarities of polyneuropathy in the peripheral t-cell lymphoma with cytostatics

This paper presents data on the occurrence and form of polyneuropathy in the peripheral T-cell lymphoma, and its main pathogenesis elements. Here the toxic effects of cytotoxic drugs and their role in the impairment of the nervous system have been describe

The possibility of administration of glutamate receptors antagonists in the treatment of parkinson's disease

Parkinson's disease is the slow-progressing chronic neurodegenerative disease. Modern medicine has not yet found methods of curing disease, however, the existing methods of conservative and surgical treatment significantly improve the patient’s quality of life and slow the progression of the diseas

The definition of specific antiparkinsonian effects of Rapitalam

Previously, we identified a metabotropic glutamate receptor 4 (mGluR4) as a potential target for drugs and predicted that activation of mGluR4 could provide a palliative advantage in the treatment of Parkinson's disease. Determine the mechanism of action of Rapitalam in vitro on a cell culture with mGluR4 over expression. The HEK293T cell line expressing human mGluR4 was used in the wor

«Антиплагиат.РГБ» - система для верификации авторских текстов

For handling the problem of falsification in science and combating the intellectual plagiarism there is required verification system of document texts originality. The «Antiplagiat.RSL» system can serve as an example of such a system, for it is an independent expertise tool, performing comparative semantic and stylistic assessment of textual matching content. Expert Certificate on the Originality of Text, issued by the Russian State Library, is an official document, containing information on presence/absence of plagiarism in scientific texts.Для решения проблемы фальсификаций в науке и борьбы с плагиатом необходима оценка оригинальности текстов документов. Реализовать ее можно с использованием системы «Антиплагиат.РГБ», которая является инструментом независимого эксперта, осуществляющего сравнительную смысловую и стилистическую оценку заимствований. Заключение об оригинальности, выданное Российской государственной библиотекой, является официальным документом, информирующим о наличии некорректных заимствований (плагиата) в научных текстах

Improving Methodological Approach to Measures Planning for Hydraulic Fracturing in Oil Fields

Goal of the research is development of an integrated approach to the planning of hydraulic fracturing (HF) treatment taking into account geo-technical, hydrodynamic, technological and economic criteria for the selection of wells for inclusion in the programs of HF with increasing importance of economic criteria. Stages of formation of the program for HF of the oil company are selected, systematized and analyzed. It is shown that high potential effectiveness of enhanced oil recovery method in fields with hard-to-recover reserves, on the one hand, and the complexity and high cost of application, on the other, determine the need to optimize the parameters of this business process at all stages of implementation and improve its planning methods. The priority directions for improving the hydraulic fracturing planning were justified: a clear definition of the criterion for the payback period of hydraulic fracturing activities, taking into account their technological features, improving the procedure for calculating the costs of implementing this technology and improving the reasonableness of selecting candidate wells for inclusion in the hydraulic fracturing program. Feasibility of using an additional criterion in the formation of hydraulic fracturing programs – marginal minimum cost-effective wall capacity – has been shown and a method for calculating it has been developed. The use of this criterion will allow to take into account not only technological limitations, but also limits of economic efficiency of conducting hydraulic fracturing at each specific well and, at the preliminary selection of candidate wells, exclude a priori unprofitable measures. It is advisable to take into account proposed directions for improving planning of hydraulic fracturing in the development of corporate regulatory documents, which will help to improve the quality of planning geological and technical measures, minimize investment risks, make more rational use of oil companies' resources for improving oil recovery, choosing the best management decision

Current regulatory requirements for non-clinical evaluation of prophylactic vaccines

Vaccines are subject to specific regulatory requirements for the evaluation of their quality, safety, and efficacy. In 2005, the World Health Organisation (WHO), as the main international organisation coordinating measures to combat infectious disease outbreaks, began developing documents on the evaluation of vaccine quality, safety, and efficacy. The world’s leading regulatory authorities (FDA, EMA, etc.) have also issued recommendations for conducting non-clinical studies of vaccines.The aim of this study was a critical review of the regulatory requirements established by foreign national and international regulatory authorities for non-clinical evaluation of the safety and efficacy of vaccines.According to the study results, since the 2000s, the WHO and the world’s leading regulatory authorities have produced more than 40 regulatory documents describing certain aspects of non-clinical studies of the safety and efficacy of vaccines. These documents can be divided into two groups: the first group addresses non-clinical studies of vaccines in general, and the second one dwells upon the evaluation of the quality, safety, and efficacy of specific types of vaccines. For the Russian guidelines on non-clinical evaluation of the quality, safety, and efficacy of immunobiologicals, the latest revision dates back to 2013 and does not provide any information on new medicinal products. Currently, work is underway to prepare the regulatory framework for medicines, including vaccines, in the Member States of the Eurasian Economic Union (EAEU). This review of regulatory documents on non-clinical safety and efficacy studies of vaccines may be useful in drafting harmonised guidelines for the relevant groups of vaccines in the EAEU. It may also be of use to developers, manufacturers, and researchers involved in the creation and non-clinical study of vaccines

Microbial landscape in hospital patients with new coronavirus disease (COVID-19), antibiotic resistance comparison vs. Pre-covid stage: a prospective study

Background. The new coronavirus infection has manifested untypically compared to other acute respiratory agents, posing a major challenge to researchers worldwide. Despite low incidence of bacterial complications, microbial coinfection plays an important role in the onset and development of severe COVID-19 to hamper diagnosis, treatment and prognosis.Objectives. A study of microbial landscape in secondary complications of COVID-19 and prevailing microbial-agent antibiotic resistance dynamics in COVID-19 vs. patients with pre-COVID community-acquired pneumonia.Methods. We analysed 1,113 bacterial sputum cultures in COVID-19 patients from 21 hospital of Krasnodar Krai. The study sample comprised 524 strains isolated from COVID-19 patients in bacteriological assays. The comparison sample included 643 positive sputum strains isolated from community-acquired pneumonia patients developing disease in outcome of acute respiratory infection in 2015–2018. The microbial aetiology landscape and strain antibiotic resistance have been compared in COVID-19 vs. patients with community-acquired pneumonia.Results. Gram-negative bacteria predominated in COVID-19 cultures (58%), followed by Gram-positive bacteria (15%) and fungi (27%). Acinetobacter baumannii (35%) and Klebsiella pneumoniae (33%) were about equally represented in Gram-negative flora, Pseudomonas aeruginosa (19%) and other microorganisms were half as common. Streptococcus pneumonia and Staphylococcus aureus accounted for 48 and 15% Gram-positive strains, respectively. Sputum-isolated fungi were mainly identifi ed as Candida albicans (89%). The Streptoccocus pneumoniae detection rate dropped to 7% in 2020 relative of other flora, which is 10 times less vs. pre-COVID rates, whilst the fungal rate increased dramatically. Antibiotic resistance increased in most isolated microbial strains.Conclusion. A Gram-negative-dominated aetiology of lower respiratory tract lesions, as well as higher risk of fungal and other opportunistic coinfections should be taken into account in patient treatment for a complicated coronavirus infection. A higher antibiotic resistance is induced by active indication-ignorant use of antibiotics, including pre-hospital treatment. A suitable treatment regimen in COVID-19 should avoid undue antibiotic prescriptions in every patient

Zero modes, beta functions and IR/UV interplay in higher-loop QED

We analyze the relation between the short-distance behavior of quantum field theory and the strong-field limit of the background field formalism, for QED effective Lagrangians in self-dual backgrounds, at both one and two loop. The self-duality of the background leads to zero modes in the case of spinor QED, and these zero modes must be taken into account before comparing the perturbative beta function coefficients and the coefficients of the strong-field limit of the effective Lagrangian. At one-loop this is familiar from instanton physics, but we find that at two-loop the role of the zero modes, and the interplay between IR and UV effects in the renormalization, is quite different. Our analysis is motivated in part by the remarkable simplicity of the two-loop QED effective Lagrangians for a self-dual constant background, and we also present here a new independent derivation of these two-loop results.Comment: 15 pages, revtex

The ethno-cultural essence of linguistic consciousness

Postmodernism gave rise to a system of values where culture is a system of signs, and ethno-linguistic consciousness is a psychic mechanism of interpreting signs in terms of a specific linguistic cultur

Challenges in development and authorisation of gene therapy products

There are a lot of diseases known today, which are caused by genetic abnormalities. Advances in genetics and biotechnology brought about gene editing technologies that can produce almost any gene, which ultimately led to the emergence of a new class of medicines - gene therapy products (GTPs). The aim of the study was to analyse international experience in development and authorisation of GTPs. The review highlights the challenges in GTP development, related to the search for an optimal approach to therapeutic gene delivery to the target cells. Viral vectors were shown to be a promising gene delivery system, with adenovirus (AV) and adeno-associated virus (AAV) based products demonstrating the highest efficacy and safety. The paper reviews current approaches to gene editing that allow modification of AVs and AAVs to improve GTP efficacy and safety. These modifications are carried out with the aim of, e.g., including a large therapeutic gene into a viral vector, decreasing viral protein expression levels, and decreasing viral vector immunogenicity. The review summarises GTP authorisation procedures in the USA and the European Union, including data on FDA and EMA subcommittees and departments entrusted with advisory functions. The paper mentions that there is one Russian-produced GTP authorised in the Russian Federation, and some other GTPs are in the pipeline. Therefore, the Russian regulatory framework and the Eurasian regulations and recommendations should be updated in order to accommodate for GTP development and authorisation