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    Π”Π•Π―ΠšΠ† Π Π•ΠΠšΠ¦Π†Π‡ N-{3-[(ΠΠ Π˜Π›-1-Π‘Π£Π›Π€ΠžΠΠ†Π›)Π†ΠœΠ†ΠΠž]-6-ΠžΠšΠ‘ΠžΠ¦Π˜ΠšΠ›ΠžΠ“Π•ΠšΠ‘Π-1,4-ДІЄН-1-Π†Π›}Π‘Π•ΠΠ—ΠΠœΠ†Π”Π†Π’

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    N-{3-[(Aryl-1-sulfonyl)imino]-6-oxocyclohexa-1,4-dienΠ΅-1-yl}benzamides have been synthesized by the reaction of the corresponding N-(4-oxocyclohexa-2,5-diene-1-ylidene)arylsulfonamides with N-chloramides with a ratio of reagents 1:2 in a solution of propan-2-one in the presence of triethylamine. The products of addition of hydrogen halides with the entry of halogen atoms in position 4 or 5 of the quinoid ring have been obtained as a result of hydrochlorination and hydrobromination of N-{3-[(aryl-1-sulfonyl)imino]-6-oxocyclohexa-1,4-diene-1-yl}benzamides. The possibility of hydrohalogenation and thiocyanation of these benzamides is determined by a steric factor. The presence of bulk substituents in the quinoid ring does not allow the introduction of a halogen atom in the 2 position of the quinoid ring. The product of aromatization of the quinoid cycle, N-{2-hydroxy-3,4-dimethyl-5-[(4-methylbenzene-1-sulfonyl)amino]phenyl}-4-methylbenzamide, was only obtained as a result of the action of hydrogen halides on 4-methyl-N-{4,5-dimethyl-3-[(4-methylbenzene-1-sulfonyl)imino]-6-oxocyclohexa-1,4-dienΠ΅-1-yl}benzamide. The thiocyanate ion addition product was obtained only for 4-chloro-N-{4-methyl-3-[(4-methylbenzene-1-sulfonyl)imino]-6-oxocyclohexa-1,4-dienΠ΅-1-yl}benzamide, which has a freeΒ ortho-position relative to the carbonyl carbon of the quinoid ring. The activitiesΒ Insulysin inhibitor, CTGF expression inhibitor, Glutamyl endopeptidase II inhibitor, Transcription factor STAT3 inhibitorΒ are possible for the products of hydrohalogenation and thiocyanation of N-{3-[(aryl-1-sulfonyl)imino]-6-oxocyclohexa-1,4-dienΠ΅-1-yl}benzamides.N-{3-[(Арил-1-ΡΡƒΠ»ΡŒΡ„ΠΎΠ½ΠΈΠ»)ΠΈΠΌΠΈΠ½ΠΎ]-6-оксоциклогСкса-1,4-Π΄ΠΈΠ΅Π½-1-ΠΈΠ»}Π±Π΅Π½Π·Π°ΠΌΠΈΠ΄Ρ‹ синтСзированы ΠΏΠΎ Ρ€Π΅Π°ΠΊΡ†ΠΈΠΈ ΡΠΎΠΎΡ‚Π²Π΅Ρ‚ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΡ… N-(4-оксоциклогСкса-2,5-Π΄ΠΈΠ΅Π½-1-ΠΈΠ»ΠΈΠ΄Π΅Π½)Π°Ρ€ΠΈΠ»ΡΡƒΠ»ΡŒΡ„ΠΎΠ½Π°ΠΌΠΈΠ΄ΠΎΠ² с N-Ρ…Π»ΠΎΡ€Π°ΠΌΠΈΠ΄Π°ΠΌΠΈ с ΡΠΎΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠ΅ΠΌ Ρ€Π΅Π°Π³Π΅Π½Ρ‚ΠΎΠ² 1:2 Π² растворС ΠΏΡ€ΠΎΠΏΠ°Π½-2-ΠΎΠ½Π° Π² присутствии триэтиламина. Π’ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π΅ гидрохлорирования ΠΈ гидробромирования N-{3-[(Π°Ρ€ΠΈΠ»-1-сулфонил)ΠΈΠΌΠΈΠ½ΠΎ]-6-оксоциклогСкса-1,4-Π΄ΠΈΠ΅Π½-1-ΠΈΠ»}Π±Π΅Π½Π·Π°ΠΌΠΈΠ΄ΠΎΠ² ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Ρ‹ ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚Ρ‹ присоСдинСния Π³Π°Π»ΠΎΠ³Π΅Π½ΠΎΠ²ΠΎΠ΄ΠΎΡ€ΠΎΠ΄ΠΎΠ² с Π²Ρ…ΠΎΠΆΠ΄Π΅Π½ΠΈΠ΅ΠΌ Π°Ρ‚ΠΎΠΌΠΎΠ² Π³Π°Π»ΠΎΠ³Π΅Π½Π° Π² ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ 4 ΠΈΠ»ΠΈ 5 Ρ…ΠΈΠ½ΠΎΠΈΠ΄Π½ΠΎΠ³ΠΎ ядра. Π’ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡ‚ΡŒ гидрогалогСнирования ΠΈ роданирования Π΄Π°Π½Π½Ρ‹Ρ… Π±Π΅Π½Π·Π°ΠΌΠΈΠ΄ΠΎΠ² опрСдСляСтся стСричСским Ρ„Π°ΠΊΡ‚ΠΎΡ€ΠΎΠΌ. НаличиС ΠΎΠ±ΡŠΠ΅ΠΌΠ½Ρ‹Ρ… замСститСлСй Π² Ρ…ΠΈΠ½ΠΎΠΈΠ΄Π½ΠΎΠΌ ядрС Π½Π΅ позволяСт ввСсти Π°Ρ‚ΠΎΠΌ Π³Π°Π»ΠΎΠ³Π΅Π½Π° Π²ΠΎ 2 ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ Ρ…ΠΈΠ½ΠΎΠΈΠ΄Π½ΠΎΠ³ΠΎ ядра – Π² Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π΅ дСйствия Π³Π°Π»ΠΎΠ³Π΅Π½ΠΎΠ²ΠΎΠ΄ΠΎΡ€ΠΎΠ΄ΠΎΠ² Π½Π° 4-ΠΌΠ΅Ρ‚ΠΈΠ»-N-{4,5-Π΄ΠΈΠΌΠ΅Ρ‚ΠΈΠ»-3-[(4-ΠΌΠ΅Ρ‚ΠΈΠ»Π±Π΅Π½Π·Π΅Π½-1-ΡΡƒΠ»ΡŒΡ„ΠΎΠ½ΠΈΠ»)ΠΈΠΌΠΈΠ½ΠΎ]-6-оксоциклогСкса-1,4-Π΄ΠΈΠ΅Π½-1-ΠΈΠ»}Π±Π΅Π½Π·Π°-ΠΌΠΈΠ΄ ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½ Ρ‚ΠΎΠ»ΡŒΠΊΠΎ ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚ Π°Ρ€ΠΎΠΌΠ°Ρ‚ΠΈΠ·Π°Ρ†ΠΈΠΈ Ρ…ΠΈΠ½ΠΎΠΈΠ΄Π½ΠΎΠ³ΠΎ Ρ†ΠΈΠΊΠ»Π° – N-{2-гидрокси-3,4-Π΄ΠΈΠΌΠ΅Ρ‚ΠΈΠ»-5-[(4-ΠΌΠ΅Ρ‚ΠΈΠ»Π±Π΅Π½Π·Π΅Π½-1-ΡΡƒΠ»ΡŒΡ„ΠΎΠ½ΠΈΠ»)Π°ΠΌΠΈΠ½ΠΎ]Ρ„Π΅Π½ΠΈΠ»}-4-ΠΌΠ΅Ρ‚ΠΈΠ»Π±Π΅Π½Π·Π°ΠΌΠΈΠ΄. ΠŸΡ€ΠΎΠ΄ΡƒΠΊΡ‚ присоСдинСния Ρ‚ΠΈΠΎΡ†ΠΈΠ°Π½Π°Ρ‚-ΠΈΠΎΠ½Π° ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½ Ρ‚ΠΎΠ»ΡŒΠΊΠΎ для 4-Ρ…Π»ΠΎΡ€-N-{4-ΠΌΠ΅Ρ‚ΠΈΠ»-3-[(4-ΠΌΠ΅Ρ‚ΠΈΠ»Π±Π΅Π½Π·Π΅Π½-1-ΡΡƒΠ»ΡŒΡ„ΠΎΠ½ΠΈΠ»)ΠΈΠΌΠΈΠ½ΠΎ]-6-оксоциклогСкса-1,4-Π΄ΠΈΠ΅Π½-1-ΠΈΠ»}Π±Π΅Π½Π·Π°ΠΌΠΈΠ΄Π°, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹ΠΉ ΠΈΠΌΠ΅Π΅Ρ‚ свободноС ΠΎΡ€Ρ‚ΠΎ-ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ ΠΏΠΎ ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΡŽ ΠΊ ΠΊΠ°Ρ€Π±ΠΎΠ½ΠΈΠ»ΡŒΠ½ΠΎΠΌΡƒ Π°Ρ‚ΠΎΠΌΡƒ ΡƒΠ³Π»Π΅Ρ€ΠΎΠ΄Π° Ρ…ΠΈΠ½ΠΎΠΈΠ΄Π½ΠΎΠ³ΠΎ ядра. Для ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚ΠΎΠ² гидрогалогСнирования ΠΈ роданирования N-{3-[(арилсулфонил)ΠΈΠΌΠΈΠ½ΠΎ]-6-оксоциклогСкса-1,4-Π΄ΠΈΠ΅Π½-1-ΠΈΠ»}Π±Π΅Π½Π·Π°ΠΌΠΈΠ΄ΠΎΠ² Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ проявлСниС активностСй Insulysin inhibitor, CTGF expression inhibitor, Glutamyl endopeptidase II inhibitor, Transcription factor STAT3 inhibitor.N-{3-[(Арил-1-ΡΡƒΠ»ΡŒΡ„ΠΎΠ½Ρ–Π»)Ρ–ΠΌΡ–Π½ΠΎ]-6-оксоциклогСкса-1,4-Π΄Ρ–Ρ”Π½-1-Ρ–Π»}Π±Π΅Π½Π·Π°ΠΌΡ–Π΄ΠΈ синтСзовано Π·Π° Ρ€Π΅Π°ΠΊΡ†Ρ–Ρ”ΡŽ Π²Ρ–Π΄ΠΏΠΎΠ²Ρ–Π΄Π½ΠΈΡ… N-(4-оксоциклогСкса-2,5-Π΄Ρ–Ρ”Π½-1-Ρ–Π»Ρ–Π΄Π΅Π½)Π°Ρ€ΠΈΠ»ΡΡƒΠ»ΡŒΡ„ΠΎΠ½Π°ΠΌΡ–Π΄Ρ–Π² Π· N-Ρ…Π»ΠΎΡ€Π°ΠΌΡ–Π΄Π°ΠΌΠΈ Π·Ρ– ΡΠΏΡ–Π²Π²Ρ–Π΄Π½ΠΎΡˆΠ΅Π½Π½ΡΠΌ Ρ€Π΅Π°Π³Π΅Π½Ρ‚Ρ–Π² 1:2 Ρƒ Ρ€ΠΎΠ·Ρ‡ΠΈΠ½Ρ– ΠΏΡ€ΠΎΠΏΠ°Π½-2-ΠΎΠ½Ρƒ Π·Π° присутності Ρ‚Ρ€ΠΈΠ΅Ρ‚ΠΈΠ»Π°ΠΌΡ–Π½Ρƒ. Π’ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ– гідрохлорування Ρ– гідробромування N-{3-[(Π°Ρ€ΠΈΠ»-1-сулфоніл)Ρ–ΠΌΡ–Π½ΠΎ]-6-оксоциклогСкса-1,4-Π΄Ρ–Ρ”Π½-1-Ρ–Π»}Π±Π΅Π½Π·Π°ΠΌΡ–Π΄Ρ–Π² ΠΎΡ‚Ρ€ΠΈΠΌΠ°Π½ΠΎ ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚ΠΈ 1,4- Ρ‚Π° 6,3-приєднання Π³Π°Π»ΠΎΠ³Π΅Π½ΠΎΠ²ΠΎΠ΄Π½Ρ–Π² Π·Ρ– входТСнням Π°Ρ‚ΠΎΠΌΡ–Π² Π³Π°Π»ΠΎΠ³Π΅Π½Ρƒ Ρƒ полоТСння 3 Π°Π±ΠΎ 4 Ρ…Ρ–Π½ΠΎΡ—Π΄Π½ΠΎΠ³ΠΎ ядра. ΠœΠΎΠΆΠ»ΠΈΠ²Ρ–ΡΡ‚ΡŒ ΠΏΠ΅Ρ€Π΅Π±Ρ–Π³Ρƒ гідрогалогСнування Ρ– роданування Π΄Π°Π½ΠΈΡ… Π±Π΅Π½Π·Π°ΠΌΡ–Π΄Ρ–Π² Π²ΠΈΠ·Π½Π°Ρ‡Π°Ρ”Ρ‚ΡŒΡΡ стСричним Ρ„Π°ΠΊΡ‚ΠΎΡ€ΠΎΠΌ. ΠΠ°ΡΠ²Π½Ρ–ΡΡ‚ΡŒ об’ємних замісників Π² Ρ…Ρ–Π½ΠΎΡ—Π΄Π½ΠΎΠΌΡƒ ядрі Π½Π΅ дозволяє ввСсти Π°Ρ‚ΠΎΠΌ Π³Π°Π»ΠΎΠ³Π΅Π½Ρƒ Ρƒ 6 полоТСння Ρ…Ρ–Π½ΠΎΡ—Π΄Π½ΠΎΠ³ΠΎ ядра – Π² Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ– Π΄Ρ–Ρ— Π³Π°Π»ΠΎΠ³Π΅Π½ΠΎΠ²ΠΎΠ΄Π½Ρ–Π² Π½Π° 4-ΠΌΠ΅Ρ‚ΠΈΠ»-N-{4,5-Π΄ΠΈΠΌΠ΅Ρ‚ΠΈΠ»-3-[(4-ΠΌΠ΅Ρ‚ΠΈΠ»Π±Π΅Π½Π·Π΅Π½-1-ΡΡƒΠ»ΡŒΡ„ΠΎΠ½Ρ–Π»)Ρ–ΠΌΡ–Π½ΠΎ]-6-оксоциклогСкса-1,4-Π΄Ρ–Ρ”Π½-1-Ρ–Π»}Π±Π΅Π½Π·Π°ΠΌΡ–Π΄ ΠΎΡ‚Ρ€ΠΈΠΌΠ°Π½ΠΎ Ρ‚Ρ–Π»ΡŒΠΊΠΈ ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚ Π°Ρ€ΠΎΠΌΠ°Ρ‚ΠΈΠ·Π°Ρ†Ρ–Ρ— Ρ…Ρ–Π½ΠΎΡ—Π΄Π½ΠΎΠ³ΠΎ Ρ†ΠΈΠΊΠ»Ρƒ – N-{2-гідрокси-3,4-Π΄ΠΈΠΌΠ΅Ρ‚ΠΈΠ»-5-[(4-ΠΌΠ΅Ρ‚ΠΈΠ»Π±Π΅Π½Π·Π΅Π½-1-ΡΡƒΠ»ΡŒΡ„ΠΎΠ½Ρ–Π»)Π°ΠΌΡ–Π½ΠΎ]Ρ„Π΅Π½Ρ–Π»}-4-ΠΌΠ΅Ρ‚ΠΈΠ»Π±Π΅Π½Π·Π°ΠΌΡ–Π΄. ΠŸΡ€ΠΎΠ΄ΡƒΠΊΡ‚ приєднання Ρ‚Ρ–ΠΎΡ†Ρ–Π°Π½Π°Ρ‚-Ρ–ΠΎΠ½Ρƒ ΠΎΡ‚Ρ€ΠΈΠΌΠ°Π½ΠΎ Ρ‚Ρ–Π»ΡŒΠΊΠΈ для 4-Ρ…Π»ΠΎΡ€-N-{4-ΠΌΠ΅Ρ‚ΠΈΠ»-3-[(4-ΠΌΠ΅Ρ‚ΠΈΠ»Π±Π΅Π½Π·Π΅Π½-1-ΡΡƒΠ»ΡŒΡ„ΠΎΠ½Ρ–Π»)Ρ–ΠΌΡ–Π½ΠΎ]-6-оксоциклогСкса-1,4-Π΄Ρ–Ρ”Π½-1-Ρ–Π»}Π±Π΅Π½Π·Π°ΠΌΡ–Π΄Ρƒ, який ΠΌΠ°Ρ” Π²Ρ–Π»ΡŒΠ½Π΅ ΠΎΡ€Ρ‚ΠΎ-полоТСння ΠΏΠΎ Π²Ρ–Π΄Π½ΠΎΡˆΠ΅Π½Π½ΡŽ Π΄ΠΎ ΠΊΠ°Ρ€Π±ΠΎΠ½Ρ–Π»ΡŒΠ½ΠΎΠ³ΠΎ Π°Ρ‚ΠΎΠΌΡƒ ΠšΠ°Ρ€Π±ΠΎΠ½Ρƒ Ρ…Ρ–Π½ΠΎΡ—Π΄Π½ΠΎΠ³ΠΎ ядра. Для ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚Ρ–Π² гідрогалогСнування Ρ– роданування N-{3-[(арилсулфоніл)Ρ–ΠΌΡ–Π½ΠΎ]-6-оксоциклогСкса-1,4-Π΄Ρ–Ρ”Π½-1-Ρ–Π»}Π±Π΅Π½Π·Π°ΠΌΡ–Π΄Ρ–Π² ΠΌΠΎΠΆΠ»ΠΈΠ²ΠΈΠΉ прояв активностСй Insulysin inhibitor, CTGF expression inhibitor, Glutamyl endopeptidase II inhibitor, Transcription factor STAT3 inhibitor

    Efficient two-frequency ultrasound extraction of Ξ²-carotene from the fungus Blakeslea trispora

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    Carotenoids are known for their lower environmental pollution, lower costs, shorter extraction time compared to regular extraction methods and higher extraction efficiency. Ultrasound has significant advantages in the extraction of a great number of biologically active compounds including carotenoids. Benefits of using ultrasound for extraction of various compounds are numerous and include effective mixing and micro-mixing, more efficient energy transfer, reduced thermal and concentration gradients, reduced temperature. The aim of this work was to investigate the influence of two-frequency ultrasound main parameters such as ultrasonic intensity, sonication time, and temperature. Application of two-frequency ultrasound (simultaneous influence of ultrasound with frequency of 20–46 kHz, intensity of 1.5–2.5 W/cm2 and frequency of 1.0–2.0 MHz, intensity of 2.0–3.0 W/cm2) raises the percentage of Ξ²-carotene extraction from biomass of the fungus Blakeslea trispora from 90–92% up to 98–99% in comparison with one frequency ultrasound. The recommended oil temperature for the extraction process is 35Β°C, because lower temperature leads to reduction of percentage of Ξ²-carotene extraction, and higher temperature promotes unjustified increase of expenditure of energy

    Cold Rolling of Steel Strips with Metal-Working Coolants

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    The efficiency of cold rolling of steel strip in the main depends on the quality of technological lubricant and its cost. In this regard, it is important to develop new compositions of effective metalworking coolants that are low cost and provide maximum reduction in the friction coefficient. We developed and tested the new compositions of metalworking coolants on the basis of vegetable oil and chicken fat. The metalworking coolants were tested in Donbas State Engineering Academy (DSEA) on a laboratory rolling mill, 100 × 100, in cold rolling of 08Kp steel. The efficiency of the coolants was determined by the stretch ratio λ and the friction coefficient μ in the deformation zone, which was found by the forward slip method. We found the metalworking coolant with 100% concentration of boric acid esters of mono- and diglycerides is the most effective in the rolling of thin steel strips. Thus, the new metalworking coolants (MWC) on the basis of boric acid esters of mono- and diglycerides, synthesized on the basis of sunflower oil, can be recommended for use in the rolling of structural steels on account of its availability, high efficiency and low cost
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