Global Influenza Hospital-based Surveillance Network (GIHSN): results of surveillance of influenza and other respiratory viruses in hospitalised patients in Brazil, 2015

Submitted by Sandra Infurna ([email protected]) on 2018-09-13T16:16:31Z No. of bitstreams: 1 marilda_siqueira_etal_IOC_2018.pdf: 797399 bytes, checksum: d8be7980d447e97f432a1230d0049417 (MD5)Approved for entry into archive by Sandra Infurna ([email protected]) on 2018-09-13T16:34:34Z (GMT) No. of bitstreams: 1 marilda_siqueira_etal_IOC_2018.pdf: 797399 bytes, checksum: d8be7980d447e97f432a1230d0049417 (MD5)Made available in DSpace on 2018-09-13T16:34:34Z (GMT). No. of bitstreams: 1 marilda_siqueira_etal_IOC_2018.pdf: 797399 bytes, checksum: d8be7980d447e97f432a1230d0049417 (MD5) Previous issue date: 2018Universidade Federal do Paraná. Departamento de Doenças Infecciosas. Curitiba, PR, Brasil / Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil.Universidade Federal do Ceará. Departamento de Patologia e Medicina Legal. Fortaleza, CE, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.Universidade Federal do Paraná. Programa de Pós-graduação em Medicina Interna e Ciências da Saúde. Curitiba, PR, Brasil.Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Laboratório de Virologia. Curitiba, PR, Brasil.Hospital Quinta D'Or. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia. Rio de Janeiro, RJ, Brasil.Fondation Merieux. Scientific Department. Lyon, France.Fondation Merieux. Scientific Department. Lyon, France.FISABIO-Public Health. Vaccines Research. Valencia, Spain.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.Global Influenza Hospital-based Surveillance NetworkBackground Influenza-like illness occurs annually worldwide, with peak timing and severity varying seasonally, resulting in significant annual mortality. Objectives There were three objectives: (1) to describe the epidemiological and clinical features of hospitalised patients with severe acute respiratory infection caused by influenza and other respiratory viruses (ORVs); (2) to report the influenza seasonality in the region and (3) to correlate findings of influenza circulation and immunisation time in Brazil. Patients/methods This study took place in three Brazilian hospitals located in cities with different climatic conditions (Curitiba (south), Rio de Janeiro (south-east) and Fortaleza (north-east)). Patients presenting with an acute process with indication for admission consisting of a predefined set of conditions potentially associated with recent influenza infection were enrolled. Results We screened 1666 patients, with 595 meeting the inclusion criteria. Influenza viruses and ORVs were detected in 6.5% and 59% of patients, respectively. Influenza-positive cases fell into the severe spectrum as compared with those with ORVs (30% vs 11%), but without any difference in mortality rates. Epidemiological results revealed variations in the peak time of influenza infections between north-east (Fortaleza) and south (Curitiba) Brazil, basically following the rain period of each region. In north-east Brazil, viral circulation was prevalent in the first 4 months of the year, indicating that the vaccination campaign occurred in a postseasonal period, possibly explaining the low effectiveness. Conclusions The active-surveillance model is a valuable tool for investigating respiratory virus impact on hospitalised patients, with influenza-infection monitoring enabling implementation of adequate preventive measures