5 research outputs found
Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study
Objective: This study aimed at investigating the association between
the rs7903146 (C/T) polymorphism of the TCF7L2 gene with obesity in a
Cameroonian population. Method: This was a case-control pilot study
including 61 obese and 61 non-obese Cameroonian adults. Anthropometric
indices of obesity, blood pressure, fasting blood glucose, and blood
lipids were measured. The rs7903146 (C/T) polymorphism of the TCF7L2
gene was genotyped using polymerase chain reaction-restriction fragment
length polymorphism (PCR-RFLP), and genotypes were correlated with
clinical and biological parameters. Results: The T allele was
predominant in the study population with a frequency of 93%. No
statistically significant difference was however observed between the
genotypic (p = 0.50) and allelic frequencies (p = 0.58) of obese and
non-obese subjects. Comparison of clinical and biochemical parameters
of C allele carriers (CX = CC + CT) with those of TT genotype showed
that there was no significant difference between the lipid profile of
these two groups. Conclusion: The rs7903146 (C/T) polymorphism of the
TCF7L2 gene might not be associated with obesity in the Cameroonian
population
Erratum to: Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study
Upon publication of the original article [1], it was noticed that the
author\u2019s name \u201cJean Jacques Noubiap\u201d was incorrectly
given as \u201cJean Jacques N. Noubiap\u201d. This has now been
acknowledged and corrected in this erratum
Erratum to: Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study
OBJECTIVE: This study aimed at investigating the association between the rs7903146 (C/T) polymorphism of the TCF7L2 gene with obesity in a Cameroonian population. METHOD: This was a case-control pilot study including 61 obese and 61 non-obese Cameroonian adults. Anthropometric indices of obesity, blood pressure, fasting blood glucose, and blood lipids were measured. The rs7903146 (C/T) polymorphism of the TCF7L2 gene was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and genotypes were correlated with clinical and biological parameters. RESULTS: The T allele was predominant in the study population with a frequency of 93%. No statistically significant difference was however observed between the genotypic (p = 0.50) and allelic frequencies (p = 0.58) of obese and non-obese subjects. Comparison of clinical and biochemical parameters of C allele carriers (CX = CC + CT) with those of TT genotype showed that there was no significant difference between the lipid profile of these two groups. CONCLUSION: The rs7903146 (C/T) polymorphism of the TCF7L2 gene might not be associated with obesity in the Cameroonian population
Association between the TCF7L2 rs12255372 (G/T) gene polymorphism and type 2 diabetes mellitus in a Cameroonian population: a pilot study.
10.1186/s40169-015-0058-1Clin Transl Med4117